|
rs2227306
|
|
Sepsis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The male population carrying the homozygote TT genotype and T allele of rs4073, the homozygote CC genotype and C allele of rs22</span>27306 and homozygote AA genotype and A allele of rs1126647 are more susceptible to sepsis, suggesting there is a protective effect in females carrying these genotypes and alleles respectively.
|
27642120 |
2016 |
|
rs2227306
|
|
Henoch-Schoenlein Purpura
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we aimed to investigate whether IL-8 gene +781 C/T (rs2227306) polymorphism has an influence on susceptibility and clinical manifestations of patients to HSP.
|
27424139 |
2016 |
|
rs2227306
|
|
Adult Liver Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our objective was to examine the association between single nucleotide polymorphisms of interleukin (IL)-8 (rs4073 and rs2227306) and IL-10 (rs1800871 and rs1800872) genes, and clinical effects of transcatheter arterial chemoembolization (TACE) and subsequent prognosis in patients with liver cancer.
|
26400525 |
2015 |
|
rs2227306
|
|
Thyroid associated opthalmopathies
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data showed that the expression level of IL-8 was associated with the development of GD, and the C-allele frequency of SNP rs2227306 was significantly higher in GD and GO patients compared with healthy controls.
|
19816813 |
2009 |
|
rs2227307
|
|
Cystic Fibrosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study identified the IL8 gene, represented by rs4073 and rs2227306 polymorphisms, and particularly the rs2227307 polymorphism, as potentiating factors for the degree of variability in the severity of CF, especially in pulmonary clinical manifestation correlated with increased morbidity and mortality.
|
27209008 |
2016 |
|
rs2227307
|
|
Cystic Fibrosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Thus, this study analyzed the interleukin 8 variants (rs4073, rs2227306, and rs2227307) and their association with the response to inhaled bronchodilators in cystic fibrosis patients.
|
28719800 |
2017 |
|
rs2227307
|
|
Childhood Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In line with a previous study, rs2466571 in CD46 (HR = 0.73, 95% CI 0.58-0.91, p = 0.006) showed nominal association with lymphoma progression, as did two highly linked SNPs in IL8 (rs4073 HR = 0.78, 95% CI 0.62-0.97, p = 0.02; rs2227307 HR = 0.75, 95% CI 0.60-0.94, p = 0.01) previously associated with overall survival.
|
25294155 |
2014 |
|
rs2227307
|
|
Adult Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In line with a previous study, rs2466571 in CD46 (HR = 0.73, 95% CI 0.58-0.91, p = 0.006) showed nominal association with lymphoma progression, as did two highly linked SNPs in IL8 (rs4073 HR = 0.78, 95% CI 0.62-0.97, p = 0.02; rs2227307 HR = 0.75, 95% CI 0.60-0.94, p = 0.01) previously associated with overall survival.
|
25294155 |
2014 |
|
rs2227307
|
|
Lung diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The severity of lung disease was associated with the following markers: transcutaneous arterial hemoglobin oxygen saturation (SaO2) (regardless of CFTR genotype, for the polymorphisms rs4073, rs2227306 and rs2227307); mucoid Pseudomonas aeruginosa (regardless of CFTR genotype, for the polymorphisms rs2227306 and rs2227307).
|
27209008 |
2016 |
|
rs2227307
|
|
Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In line with a previous study, rs2466571 in CD46 (HR = 0.73, 95% CI 0.58-0.91, p = 0.006) showed nominal association with lymphoma progression, as did two highly linked SNPs in IL8 (rs4073 HR = 0.78, 95% CI 0.62-0.97, p = 0.02; rs2227307 HR = 0.75, 95% CI 0.60-0.94, p = 0.01) previously associated with overall survival.
|
25294155 |
2014 |
|
rs2227307
|
|
Idiopathic Pulmonary Fibrosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The minor allele frequencies of rs4073T>A and rs2227307T>G were significantly lower in the 162 subjects with surgical biopsy-proven IPF and 75 subjects with clinical IPF compared with normal controls in the recessive model (OR = 0.46 and 0.48, p = 0.006 and 0.007, respectively).
|
21649933 |
2011 |
|
rs2227532
|
|
Periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Based on current evidence, the IL-8 rs4073, A2767T, T11722T2, rs2234671, rs2230054, rs1126579, rs2227306, rs2227307, rs2227532, and T-738A polymorphisms were not associated with periodontitis susceptibility; the IL-8 C1633T and rs1126580 polymorphisms were associated with increased risk of periodontitis.
|
28446725 |
2017 |
|
rs2227532
|
|
Periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
This review assesses the associations of interleukin-8 gene (IL-8) -251A/T (rs4073) and -845T/C (rs2227532) polymorphisms with susceptibility to periodontitis.
|
25299389 |
2015 |
|
rs2227532
|
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The goal of this study was to evaluate the influence that polymorphisms in the cytokine genes known as TNF-α-308 G/A (rs1800629), TNF-α-857 C/T (rs1799724), IL-8-251 T/A (rs4073), IL-8-845 T/C (rs2227532), and IL-10-592 C/A (rs1800872) have on changes to mRNA expression levels and on the risks of chronic gastritis (CG) and gastric cancer (GC).
|
26088449 |
2015 |
|
rs2227532
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
The goal of this study was to evaluate the influence that polymorphisms in the cytokine genes known as TNF-α-308 G/A (rs1800629), TNF-α-857 C/T (rs1799724), IL-8-251 T/A (rs4073), IL-8-845 T/C (rs2227532), and IL-10-592 C/A (rs1800872) have on changes to mRNA expression levels and on the risks of chronic gastritis (CG) and gastric cancer (GC).
|
26088449 |
2015 |
|
rs2227543
|
|
IGA Glomerulonephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genotyping data from 192 patients with childhood IgAN and 397 controls showed significant differences in the frequencies of the CXCL8 gene with rs2227306 (dominant, P = 0.019; overdominant, P = 0.009), rs2227543 (dominant, P = 0.01; overdominant, P = 0.0057), and rs4073 (codominant, P = 0.034; dominant, P = 0.011; overdominant, P = 0.022).
|
21214373 |
2011 |
|
rs373821605
|
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
|
0.010 |
GeneticVariation
|
BEFREE |
The novel S59P mutation in the TNFRSF1A gene identified in an adult onset TNF receptor associated periodic syndrome (TRAPS) constitutively activates NF-κB pathway.
|
25888769 |
2015 |
|
rs4073
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
After adjustment for confounders, polymorphisms in COX-2 (rs689466) and IL-8 (rs4073) were not significantly associated with prostate cancer risk.
|
20431935 |
2010 |
|
rs4073
|
|
Malignant neoplasm of prostate
|
|
0.050 |
GeneticVariation
|
BEFREE |
After adjustment for confounders, polymorphisms in COX-2 (rs689466) and IL-8 (rs4073) were not significantly associated with prostate cancer risk.
|
20431935 |
2010 |
|
rs4073
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
The purpose of this study was to evaluate the relationship between single-nucleotide polymorphism (SNP) rs2228001 in xeroderma pigmentosum group C (XPC), SNP rs4073 in interleukin 8 (IL8), and SNP rs2279744 in mouse double minute 2 (MDM2) homolog gene with PCa susceptibility.
|
26135929 |
2015 |
|
rs4073
|
|
Malignant neoplasm of prostate
|
|
0.050 |
GeneticVariation
|
BEFREE |
The frequency of the A allele of the rs4073 was significantly lower in PCa group compared with BPH group (OR (95% CI) = 0.62 (0.46-0.84), adjusted P value = 0.006).
|
30641210 |
2019 |
|
rs4073
|
|
Malignant neoplasm of prostate
|
|
0.050 |
GeneticVariation
|
BEFREE |
Minor alleles of rs2243250 (T) in IL4 (OR = 1.46, 95% CI 1.03-2.08, P-trend = 0.03), rs1800896 (G) in IL10 (OR = 0.77, 95% CI 0.61-0.96, P-trend = 0.02), rs2430561 (A) in IFNG (OR = 1.33, 95% CI 1.02-1.74; P-trend = 0.04), rs3747531 (C) in MSR1 (OR = 0.55, 95% CI 0.32-0.95; P-trend = 0.03), and possibly rs4073 (A) in IL8 (OR = 0.81, 95% CI 0.64-1.01, P-trend = 0.06) were associated with higher- (Gleason 7-10; N = 222), but not lower- (Gleason 2-6; N = 380) grade prostate cancer.
|
28317149 |
2017 |
|
rs4073
|
|
Malignant neoplasm of prostate
|
|
0.050 |
GeneticVariation
|
BEFREE |
The major findings of this meta-analysis suggested that IL-8 rs4073 polymorphism is significantly associated with risk of prostate cancer.
|
31718853 |
2019 |
|
rs4073
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
The frequency of the A allele of the rs4073 was significantly lower in PCa group compared with BPH group (OR (95% CI) = 0.62 (0.46-0.84), adjusted P value = 0.006).
|
30641210 |
2019 |
|
rs4073
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Minor alleles of rs2243250 (T) in IL4 (OR = 1.46, 95% CI 1.03-2.08, P-trend = 0.03), rs1800896 (G) in IL10 (OR = 0.77, 95% CI 0.61-0.96, P-trend = 0.02), rs2430561 (A) in IFNG (OR = 1.33, 95% CI 1.02-1.74; P-trend = 0.04), rs3747531 (C) in MSR1 (OR = 0.55, 95% CI 0.32-0.95; P-trend = 0.03), and possibly rs4073 (A) in IL8 (OR = 0.81, 95% CI 0.64-1.01, P-trend = 0.06) were associated with higher- (Gleason 7-10; N = 222), but not lower- (Gleason 2-6; N = 380) grade prostate cancer.
|
28317149 |
2017 |