|
rs4373814
|
|
Hypertensive disease
|
|
0.810 |
GeneticVariation
|
BEFREE |
However, SNP rs4373814, a variant in CACNB2, showed a relevant association with a decreased risk of hypertension.
|
24338417 |
2013 |
|
rs16998073
|
|
Hypertensive disease
|
|
0.760 |
GeneticVariation
|
BEFREE |
For example, rs16998073 had a 72% increased risk for hypertension under the co-dominant model (95% confidence interval: 1.20-2.45; P=0.003).
|
20542020 |
2010 |
|
rs16998073
|
|
Hypertensive disease
|
|
0.760 |
GeneticVariation
|
BEFREE |
The present study confirmed the significant association of ATP2B1 rs17249754 with risk of hypertension among Chinese children, but failed to replicate the association of CSK rs1378942, MTHFR rs1801133, CYP17A1 rs1004467, STK39 rs3754777 and FGF5 rs16998073 with BP/risk of hypertension.
|
23759979 |
2014 |
|
rs16998073
|
|
Hypertensive disease
|
|
0.760 |
GeneticVariation
|
BEFREE |
The genetic risk score, calculated as the sum of BP-increasing alleles of FGF5-rs16998073, CYP17A1-rs11191548, CYP17A1-rs1004467 and MTHFR-rs17367504, was significantly associated with increased SBP (1.16 mmHg/allele, P = 9.01E-5), DBP (0.51 mmHg/allele, P = 4.40E-4) and hypertension risk (OR = 1.22/allele, P = 2.74E-7).
|
20852445 |
2011 |
|
rs16998073
|
|
Hypertensive disease
|
|
0.760 |
GeneticVariation
|
BEFREE |
The present meta-analysis indicated significant associations of both CYP17A1 rs11191548 and FGF5 rs16998073 polymorphisms with hypertension susceptibility in East Asians.
|
22959498 |
2013 |
|
rs16998073
|
|
Hypertensive disease
|
|
0.760 |
GeneticVariation
|
BEFREE |
In contrast, in inactive group, two polymorphisms and genetic risk score were significantly associated with SBP (rs17249754: β = 1.26, 95% confidence interval (CI) 0.61-1.90, p < 0.001; rs1004467: β = 0.68, 95%CI 0.03-1.32, p = 0.039; genetic risk score: β = 1.54, 95%CI 0.74-2.33, p < 0.001); three polymorphisms and genetic risk score were significantly associated with hypertension (rs17249754: odds ratio (OR) = 1.27, 95%CI 1.08-1.49, p = 0.004; rs1378942: OR = 1.25, 95%CI 1.00-1.57, p = 0.050 (marginally significant); rs16998073: OR = 1.17, 95%CI 1.01-1.37, p = 0.044; genetic risk score: OR = 1.38, 95%CI 1.13-1.68, p = 0.001).
|
23102448 |
2012 |
|
rs16998073
|
|
Hypertensive disease
|
|
0.760 |
GeneticVariation
|
BEFREE |
Our recent genetic study as well as robust evidences reported by previous genome-wide association studies (GWASs) have indicated that the single nucleotide polymorphism rs16998073, located near gene anthrax toxin receptor 2 (ANTXR2), was significantly associated with hypertension in Asians and Europeans.
|
28077422 |
2017 |
|
rs820430
|
|
Hypertensive disease
|
|
0.710 |
GeneticVariation
|
BEFREE |
The present study indicated that the disease-associated T allele of a new hypertension risk variant rs820430 linked increased hypertension risk through higher SLC4A7 expression, and rs820430 functioned as an enhancer of SLC4A7 transcription by allele distinctively increased c-Fos transcription factor binding.
|
27784683 |
2017 |
|
rs1458038
|
|
Hypertensive disease
|
|
0.710 |
GeneticVariation
|
BEFREE |
Our findings suggest high BMI increases the effect of the blood pressure-increasing allele at rs1458038 near FGF5, further highlighting the importance of obesity prevention in reducing hypertension risk.
|
25618516 |
2015 |
|
rs1468326
|
|
Hypertensive disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
No association was found between WNK1 polymorphisms or haplotypes with hypertension; however, one SNP rs1468326, located 3 kb from the WNK1 promoter, was found to be nominally associated with severity of hypertension, with both systolic blood pressure (BP) (Z = +2.24, P = 0.025) and diastolic BP (Z = +1.99, P = 0.046).
|
15888480 |
2005 |
|
rs1468326
|
|
Hypertensive disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms rs3754777 (STK39) and rs1468326 (WNK1) were associated with hypertension and BP in our multicenter Belgian case-control study, which supports the role of STK39 and WNK1 as potential hypertension susceptibility genes.
|
27082544 |
2016 |
|
rs1468326
|
|
Hypertensive disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
In conclusion, SNP rs1468326 of WNK1, rs6749447 of STK39, and WNK1 haplotype AGACAGGAATCGT were associated with hypertension in Tibetan individuals.Environ.Mol.Mutagen.59:151-160, 2018.© 2017 Wiley Periodicals, Inc.
|
28945285 |
2018 |
|
rs1468326
|
|
Hypertensive disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Two polymorphisms were found to be associated with hypertension risk with odds ratio of 1.55 for WNK1 rs1468326 (P<0.001) and 1.88 for WNK4 rs9916754 (P<0.001) in the first population, and 1.54 for WKN1 rs1468326, and 1.82 for WNK4 rs9916754 in the second population.
|
21704025 |
2011 |
|
rs1800764
|
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of our study was to characterize the association of clinical and genetic risk factors such as: ACE genotype (rs17997552, rs1800764, rs4459609) and RGS2 (rs2746071) with the development of hypertension (HT) and non-dipping phenomenon in patients with type 1 diabetes mellitus (T1DM).
|
24562335 |
2014 |
|
rs1800764
|
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
A tag-SNP, rs1800764 on LD block 2, upstream of and near the ACE promoter, was significantly associated with young-onset hypertension (p = 0.04).
|
23469169 |
2013 |
|
rs17782313
|
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The genetic risk score (GRS), based on three significant SNPs (FTO rs9939609, MC4R rs17782313, GNPDA2 rs10938397), showed a positive association with SBP (P=5.17 × 10(-4)) and risk of hypertension (OR=1.22, 95% CI 1.12-1.33, P=6.07 × 10(-6)).
|
23588626 |
2013 |
|
rs17782313
|
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Common genetic variants of FTO rs9939609 have positive associations with BMI and neck circumference and MC4R rs17782313 in women, but a negative association with diastolic and mean blood pressure in men with hypertension.
|
23849767 |
2013 |
|
rs12229654
|
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The polymorphism rs12229654 was thus associated with both systolic and diastolic blood pressure and with hypertension.
|
28562329 |
2017 |
|
rs12229654
|
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Five gene variants, rs11066280 (C12orf51), rs12229654 and rs3782889 (MYL2), rs2072134 (OAS3), rs2093395 (TREML2), and rs17249754 (ATP2B1), were found to be associated with hypertension mostly in men (P = 4.76 × 10(-14) to 4.46 × 10(-7) in the joint analysis); three SNPs (rs11066280, rs12229654, and rs3782889) remained significant after Bonferroni correction in an independent population.
|
24142389 |
2014 |
|
rs11646213
|
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
In summary, our data suggests that the CDH13 T>A (rs11646213) polymorphism is associated with decreased risk of developing hypertension in the Mexican population.
|
27682011 |
2017 |
|
rs11646213
|
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213.
|
23976997 |
2013 |
|
rs9913883
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four SNPs (rs9899362, rs10491093, rs11658572 and rs9913883) were associated with the development of hypertension (P<0.05), but these associations require confirmation in future studies.
|
17728798 |
2008 |
|
rs9899362
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four SNPs (rs9899362, rs10491093, rs11658572 and rs9913883) were associated with the development of hypertension (P<0.05), but these associations require confirmation in future studies.
|
17728798 |
2008 |
|
rs9381299
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Validation in larger bevacizumab-treated cohorts supported association between rs9381299 with early grade 3+ hypertension (<i>P</i> = 0.01; OR, 2.4) and systolic blood pressure >180 mm Hg (<i>P</i> = 0.02; OR, 2.1). rs834576 was associated with early grade 3+ hypertension in CALGB 40502 (<i>P</i> = 0.03; OR, 2.9).
|
29871907 |
2018 |
|
rs897876
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
After an average 7.79 ± 0.28 years of follow-up, the TT genotype of rs897876 was independently associated with an increased risk (in a recessive model) of coronary artery disease (HR, 2.20; 95% CI, 1.20-4.03; p = 0.01) and total cardiovascular events (HR, 1.99; 95% CI, 1.29-3.06; p = 0.002), suggesting that the TT genotype of rs897876C, which is associated with nighttime pulse pressure in young-onset hypertension patients, could be a genetic prognostic factor of cardiovascular events in the general cohort.
|
24892410 |
2014 |