|
rs2681472
|
|
Hypertensive disease
|
|
0.860 |
GeneticVariation
|
BEFREE |
Recently STK39 rs3754777, ATP2B1 rs2681472 and rs17249754 have been associated with BP variation and hypertension.
|
31242870 |
2019 |
|
rs2681472
|
|
Hypertensive disease
|
|
0.860 |
GeneticVariation
|
BEFREE |
The aim of this study was to assess the associations of <i>ATP2B1</i> rs2681472 and <i>CACNB2</i> rs12258967 gene polymorphisms with high blood pressure (HBP) among Lithuanian children and adolescents aged 12-15 years.
|
29982197 |
2018 |
|
rs2681472
|
|
Hypertensive disease
|
|
0.860 |
GeneticVariation
|
BEFREE |
Recently, a genome-wide association study (GWAS) identified the single-nucleotide polymorphism, rs2681472, as a new hypertension susceptibility genetic variant.
|
24642721 |
2014 |
|
rs2681472
|
|
Hypertensive disease
|
|
0.860 |
GeneticVariation
|
BEFREE |
The major findings of this study were that four loci--rs10858911, rs2681472, rs17249754 and rs1401982--associated with any or all of four traits: hypertension (P = 0.001-4.6E-05; odds ratio, 0.83-0.87), systolic BP (P = 0.003-0.004), diastolic BP (P = 0.002-0.003) and cf-PWV (P = 0.002-0.004).
|
23079715 |
2013 |
|
rs2681472
|
|
Hypertensive disease
|
|
0.860 |
GeneticVariation
|
BEFREE |
Association of allelic variants in rs2681472 and rs2681492 with hypertension, rs987237 and rs7826222 with waist circumference and rs864745, rs7578597 and rs2943641 with diabetes were not significant.
|
23036851 |
2013 |
|
rs2681472
|
|
Hypertensive disease
|
|
0.860 |
GeneticVariation
|
BEFREE |
The results suggested that rs2681472 was significantly associated with hypertension risk in East Asians (OR = 1.18, 95% CI 1.10-1.27, p = 0.000).
|
22229515 |
2012 |
|
rs1799945
|
|
Hypertensive disease
|
|
0.840 |
GeneticVariation
|
BEFREE |
Compared with WT/WT, H63D</span>/WT and H63D</span>/H6</span>3D participants had a 2% to 4% and 4% to 7% absolute increase in hypertension risk at each visit, respectively.
|
30571559 |
2019 |
|
rs1799945
|
|
Hypertensive disease
|
|
0.840 |
GeneticVariation
|
BEFREE |
According to GWAS studies, iron regulatory protein HFE gene variant H63D (rs1799945) was associated with hypertension, an observation which we were able to confirm also in our TAMRISK cohort.
|
28151915 |
2017 |
|
rs1799945
|
|
Hypertensive disease
|
|
0.840 |
GeneticVariation
|
BEFREE |
We found that individuals with the mutated form of the H63D polymorphic site (G-allele) had a 1.4-fold risk (P = 0.037, 95% confidence interval [CI] 1.02-1.89) for hypertension at the age of 50 years compared with the CC genotype carriers.
|
25634189 |
2015 |
|
rs1799945
|
|
Hypertensive disease
|
|
0.840 |
GeneticVariation
|
BEFREE |
Multivariate analysis revealed that the odds of CHF was higher in females [Odds Ratio (OR) = 2·9, P < 0·01], individuals with pre-HCT chest radiation (OR = 4·7, P = 0·05), hypertension (OR = 2·9, P = 0·01), and with variants of genes coding for the NAD(P)H-oxidase subunit RAC2 (rs13058338, 7508T→A; OR = 2·8, P < 0·01), HFE (rs1799945, 63C→G; OR = 2·5, P = 0·05) or the doxorubicin efflux transporter ABCC2 (rs8187710, 1515G→A; OR = 4·3, P < 0·01).
|
23927520 |
2013 |
|
rs13333226
|
|
Hypertensive disease
|
|
0.810 |
GeneticVariation
|
BEFREE |
In a subset of 13,446 individuals with estimated glomerular filtration rate (eGFR) measurements, we show that rs13333226 is independently associated with hypertension (unadjusted for eGFR: 0.89 [0.83-0.96], p = 0.004; after eGFR adjustment: 0.89 [0.83-0.96], p = 0.003).
|
21082022 |
2010 |
|
rs2932538
|
|
Hypertensive disease
|
|
0.810 |
GeneticVariation
|
BEFREE |
SNP rs2932538, a variant in MOV10, was found to be significantly associated with an increased risk of hypertension.
|
24338417 |
2013 |
|
rs4373814
|
|
Hypertensive disease
|
|
0.810 |
GeneticVariation
|
BEFREE |
However, SNP rs4373814, a variant in CACNB2, showed a relevant association with a decreased risk of hypertension.
|
24338417 |
2013 |
|
rs6596140
|
|
Hypertensive disease
|
|
0.810 |
GeneticVariation
|
BEFREE |
Using a family-based association test, we found an association with SNPs on chromosome 5q31.1 (rs6596140; P<9 × 10(-8)) for hypertension.
|
22384028 |
2012 |
|
rs17249754
|
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recently STK39 rs3754777, ATP2B1 rs2681472 and rs17249754 have been associated with BP variation and hypertension.
|
31242870 |
2019 |
|
rs17249754
|
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, people with the major allele of ATP2B1 rs17249754 are susceptible to hypertension especially in low intake of Ca and high ratio of Na and K.
|
28934190 |
2017 |
|
rs17249754
|
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
The MDR analysis demonstrated that the interaction of rs2070759, rs17249754, TC, TG, and BMI increased the susceptibility to hypertension.
|
26933664 |
2016 |
|
rs17249754
|
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
That is, carriers with ATP2B1 rs17249754 homozygote mutant allele may be at higher risk of hypertension, when they consume excessive sodium intake.
|
27149052 |
2016 |
|
rs17249754
|
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
The present study confirmed the significant association of ATP2B1 rs17249754 with risk of hypertension among Chinese children, but failed to replicate the association of CSK rs1378942, MTHFR rs1801133, CYP17A1 rs1004467, STK39 rs3754777 and FGF5 rs16998073 with BP/risk of hypertension.
|
23759979 |
2014 |
|
rs17249754
|
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Five gene variants, rs11066280 (C12orf51), rs12229654 and rs3782889 (MYL2), rs2072134 (OAS3), rs2093395 (TREML2), and rs17249754 (ATP2B1), were found to be associated with hypertension mostly in men (P = 4.76 × 10(-14) to 4.46 × 10(-7) in the joint analysis); three SNPs (rs11066280, rs12229654, and rs3782889) remained significant after Bonferroni correction in an independent population.
|
24142389 |
2014 |
|
rs17249754
|
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
We also observed a significant association of 4 SNPs and the GRS with hypertension (ATP2B1 rs17249754: P = 0.02; CSK rs1378942: P = 0.02; CYP17A1 rs1004467: P = 0.02; MTHFR rs1801133: P = 0.03; GRS: P = 0.0004).
|
23591986 |
2013 |
|
rs17249754
|
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
The major findings of this study were that four loci--rs10858911, rs2681472, rs17249754 and rs1401982--associated with any or all of four traits: hypertension (P = 0.001-4.6E-05; odds ratio, 0.83-0.87), systolic BP (P = 0.003-0.004), diastolic BP (P = 0.002-0.003) and cf-PWV (P = 0.002-0.004).
|
23079715 |
2013 |
|
rs17249754
|
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
All studies evaluating the association between rs2681472 (rs17249754 or rs11105378) and hypertension risk in East Asians were included.
|
22229515 |
2012 |
|
rs17249754
|
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
In contrast, in inactive group, two polymorphisms and genetic risk score were significantly associated with SBP (rs17249754: β = 1.26, 95% confidence interval (CI) 0.61-1.90, p < 0.001; rs1004467: β = 0.68, 95%CI 0.03-1.32, p = 0.039; genetic risk score: β = 1.54, 95%CI 0.74-2.33, p < 0.001); three polymorphisms and genetic risk score were significantly associated with hypertension (rs17249754: odds ratio (OR) = 1.27, 95%CI 1.08-1.49, p = 0.004; rs1378942: OR = 1.25, 95%CI 1.00-1.57, p = 0.050 (marginally significant); rs16998073: OR = 1.17, 95%CI 1.01-1.37, p = 0.044; genetic risk score: OR = 1.38, 95%CI 1.13-1.68, p = 0.001).
|
23102448 |
2012 |
|
rs17249754
|
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
An additional hypertension case-control study confirmed that rs17249754 (in ATP2B1) increases hypertension risk in both the KARE and Health2 (meta-analysis, P-value=4.25 x 10(-9)) cohorts.
|
19960030 |
2010 |