|
rs1241312324
|
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Their peripheral blood mononuclear cells (PBMC) had increased basal NF-kappaB activation compared with healthy controls and also had increased p50 nuclear expression following tumour necrosis factor (TNF) stimulation compared with PBMC from healthy controls, as well as T50M (T79M) and C88R (C117R) patients with TRAPS and patients with rheumatoid arthritis (RA).
|
18086728 |
2008 |
|
rs1241312324
|
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
|
0.010 |
GeneticVariation
|
BEFREE |
Their peripheral blood mononuclear cells (PBMC) had increased basal NF-kappaB activation compared with healthy controls and also had increased p50 nuclear expression following tumour necrosis factor (TNF) stimulation compared with PBMC from healthy controls, as well as T50M (T79M) and C88R (C117R) patients with TRAPS and patients with rheumatoid arthritis (RA).
|
18086728 |
2008 |
|
rs4648022
|
|
Lymphoma, Non-Hodgkin
|
|
0.010 |
GeneticVariation
|
BEFREE |
In gene-level analysis of the NF-kappaB pathway, only NFKB1 showed a statistically significant association with NHL (P = 0.049), and one NFKB1 tagSNP (rs4648022) was associated with NHL risk overall (ordinal OR, 0.59; 95% CI, 0.41-0.84; Ptrend = 0.0037) and for each of the common subtypes.
|
18990758 |
2008 |
|
rs28362491
|
|
Cervical Squamous Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine whether the functional NFKB1 -94 insertion/deletion ATTG polymorphism (rs28362491) is associated with cervical squamous cell carcinoma (CSCC).
|
19892748 |
2010 |
|
rs4648110
|
|
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
The most significant finding (nominal P = 0.0004; false discovery rate q = 0.037) was a combined genotype association across IKBKB SNP rs5029748 (1 or 2 variant alleles), IL6 rs1800797 (1 or 2 variant alleles), and NFKB1 rs4648110 (2 variant alleles) which conferred an ~80% decreased risk of colon cancer.
|
21129206 |
2010 |
|
rs4648110
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The most significant finding (nominal P = 0.0004; false discovery rate q = 0.037) was a combined genotype association across IKBKB SNP rs5029748 (1 or 2 variant alleles), IL6 rs1800797 (1 or 2 variant alleles), and NFKB1 rs4648110 (2 variant alleles) which conferred an ~80% decreased risk of colon cancer.
|
21129206 |
2010 |
|
rs28362491
|
|
Ulcerative Colitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genotypes of nuclear factor (NF)-κB (NFKB1) NFκB -94ins/del (rs28362491); peroxisome proliferator-activated receptor (PPAR)-γ (PPARγ) PPARγ Pro12Ala (rs 1801282) and C1431T (rs 3856806); pregnane X receptor (PXR) (NR1I2) PXR A-24381C (rs1523127), C8055T (2276707), and A7635G (rs 6785049); and liver X receptor (LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients, 495 ulcerative colitis (UC) patients, and 779 healthy controls.
|
21245992 |
2011 |
|
rs4648004
|
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Statistically significant results found for the various QTs and SNPs were: rs3774933, rs230528, rs230521, rs1005819 and rs1609798 (intronic, NFKB1) with APOB; rs5361 (Missense, R greatr than S, SELE) and rs4648004 (Intronic, NFKB1) with FBG; rs4220 (Missense, K greater than R, FGB) with HCY; and rs3025035 (Intronic, VEGFA) with CHOL-H. SNPs in SELE, VEGFA, FGB and NFKB1 genes impact significantly on levels of quantitative precursors of CAD in Marwaris.
|
22116284 |
2011 |
|
rs230521
|
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Statistically significant results found for the various QTs and SNPs were: rs3774933, rs230528, rs230521, rs1005819 and rs1609798 (intronic, NFKB1) with APOB; rs5361 (Missense, R greatr than S, SELE) and rs4648004 (Intronic, NFKB1) with FBG; rs4220 (Missense, K greater than R, FGB) with HCY; and rs3025035 (Intronic, VEGFA) with CHOL-H. SNPs in SELE, VEGFA, FGB and NFKB1 genes impact significantly on levels of quantitative precursors of CAD in Marwaris.
|
22116284 |
2011 |
|
rs1609798
|
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Statistically significant results found for the various QTs and SNPs were: rs3774933, rs230528, rs230521, rs1005819 and rs1609798 (intronic, NFKB1) with APOB; rs5361 (Missense, R greatr than S, SELE) and rs4648004 (Intronic, NFKB1) with FBG; rs4220 (Missense, K greater than R, FGB) with HCY; and rs3025035 (Intronic, VEGFA) with CHOL-H. SNPs in SELE, VEGFA, FGB and NFKB1 genes impact significantly on levels of quantitative precursors of CAD in Marwaris.
|
22116284 |
2011 |
|
rs28362491
|
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
Recently, a common insertion/deletion (-94insertion/deletion ATTG, rs28362491) polymorphism in the NFkappaB1 promoter region has been extensively investigated for association with cancer risk but the results have been inconsistent.
|
22320942 |
2011 |
|
rs28362491
|
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
Recently, a common insertion/deletion (-94insertion/deletion ATTG, rs28362491) polymorphism in the NFkappaB1 promoter region has been extensively investigated for association with cancer risk but the results have been inconsistent.
|
22320942 |
2011 |
|
rs3774964
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, a significant combined effect of rs3774959 and rs3774964 in the NFKB1 gene with rs2228991 in the REST gene on CRC risk was observed.
|
22530801 |
2012 |
|
rs3774959
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, a significant combined effect of rs3774959 and rs3774964 in the NFKB1 gene with rs2228991 in the REST gene on CRC risk was observed.
|
22530801 |
2012 |
|
rs28362491
|
|
Rheumatoid Arthritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
NFKB1-94ATTG ins/del polymorphism (rs28362491) is associated with cardiovascular disease in patients with rheumatoid arthritis.
|
22742859 |
2012 |
|
rs28362491
|
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
NFKB1-94ATTG ins/del polymorphism (rs28362491) is associated with cardiovascular disease in patients with rheumatoid arthritis.
|
22742859 |
2012 |
|
rs4648068
|
|
Malignant neoplasm of stomach
|
|
0.030 |
GeneticVariation
|
BEFREE |
Homozygous rs4648068 GG was associated with an increased risk of gastric cancer, especially for the lymph node status and serosa invasion in Han Chinese population.
|
22776619 |
2012 |
|
rs4648068
|
|
Stomach Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Homozygous rs4648068 GG was associated with an increased risk of gastric cancer, especially for the lymph node status and serosa invasion in Han Chinese population.
|
22776619 |
2012 |
|
rs4648068
|
|
Tumor Cell Invasion
|
|
0.010 |
GeneticVariation
|
BEFREE |
Homozygous rs4648068 GG was associated with an increased risk of gastric cancer, especially for the lymph node status and serosa invasion in Han Chinese population.
|
22776619 |
2012 |
|
rs4648068
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, rs4648068 genotypes were not associated with tumor differentiation in gastric cancer patients.
|
22776619 |
2012 |
|
rs4648127
|
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, after adjusting for multiple comparisons, the only SNP that retained a significant association with lung cancer in the replication phase was reference SNP rs4648127 (nuclear factor of kappa light polypeptide gene enhancer of B-cells 1 [NFKB1]) (multiple testing-adjusted P(trend) = .02).
|
23044494 |
2012 |
|
rs4648127
|
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, after adjusting for multiple comparisons, the only SNP that retained a significant association with lung cancer in the replication phase was reference SNP rs4648127 (nuclear factor of kappa light polypeptide gene enhancer of B-cells 1 [NFKB1]) (multiple testing-adjusted P(trend) = .02).
|
23044494 |
2012 |
|
rs4648127
|
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, after adjusting for multiple comparisons, the only SNP that retained a significant association with lung cancer in the replication phase was reference SNP rs4648127 (nuclear factor of kappa light polypeptide gene enhancer of B-cells 1 [NFKB1]) (multiple testing-adjusted P(trend) = .02).
|
23044494 |
2012 |
|
rs28362491
|
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aimed to clarify the influence of a common insertion/deletion polymorphism (-94 ins/del ATTG, rs28362491) in the NFKB1 promoter on RCC susceptibility.
|
23295440 |
2013 |
|
rs28362491
|
|
Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aimed to clarify the influence of a common insertion/deletion polymorphism (-94 ins/del ATTG, rs28362491) in the NFKB1 promoter on RCC susceptibility.
|
23295440 |
2013 |