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rs1800470
|
|
Osteoporosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
We have shown that a T(869)-->C polymorphism of the transforming growth factor-beta1 (TGF-beta1) gene, which results in a Leu-->Pro substitution at amino acid 10, is associated with bone mineral density in Japanese adolescents and postmenopausal women, with genetic susceptibility to osteoporosis or spinal osteoarthritis, and with the outcome of treatment for osteoporosis with active vitamin D. I here review our recent studies, which have provided insight into the function of TGF-beta1 as well as into the role of genetic factors in the development of osteoporosis and osteoarthritis.
|
10996011 |
2000 |
|
rs1800470
|
|
Degenerative polyarthritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We have shown that a T(869)-->C polymorphism of the transforming growth factor-beta1 (TGF-beta1) gene, which results in a Leu-->Pro substitution at amino acid 10, is associated with bone mineral density in Japanese adolescents and postmenopausal women, with genetic susceptibility to osteoporosis or spinal osteoarthritis, and with the outcome of treatment for osteoporosis with active vitamin D. I here review our recent studies, which have provided insight into the function of TGF-beta1 as well as into the role of genetic factors in the development of osteoporosis and osteoarthritis.
|
10996011 |
2000 |
|
rs1800470
|
|
Spondylarthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have shown that a T(869)-->C polymorphism of the transforming growth factor-beta1 (TGF-beta1) gene, which results in a Leu-->Pro substitution at amino acid 10, is associated with bone mineral density in Japanese adolescents and postmenopausal women, with genetic susceptibility to osteoporosis or spinal osteoarthritis, and with the outcome of treatment for osteoporosis with active vitamin D. I here review our recent studies, which have provided insight into the function of TGF-beta1 as well as into the role of genetic factors in the development of osteoporosis and osteoarthritis.
|
10996011 |
2000 |
|
rs1800470
|
|
Osteoarthritis, Spine
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have shown that a T(869)-->C polymorphism of the transforming growth factor-beta1 (TGF-beta1) gene, which results in a Leu-->Pro substitution at amino acid 10, is associated with bone mineral density in Japanese adolescents and postmenopausal women, with genetic susceptibility to osteoporosis or spinal osteoarthritis, and with the outcome of treatment for osteoporosis with active vitamin D. I here review our recent studies, which have provided insight into the function of TGF-beta1 as well as into the role of genetic factors in the development of osteoporosis and osteoarthritis.
|
10996011 |
2000 |
|
rs1800470
|
|
Renal Insufficiency
|
|
0.010 |
GeneticVariation
|
BEFREE |
To determine whether genetic factors are involved in the development of renal dysfunction due to cyclosporine nephrotoxicity, we analyzed 2 polymorphisms in the signal sequence of the transforming growth factor (TGF)-beta 1 gene; codon 10 (Leu(10) --> Pro) and codon 25 (Arg(25) --> Pro).
|
11008076 |
2000 |
|
rs1800470
|
|
Osteoporosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Transforming growth factor-beta1 is an important local regulator of bone metabolism, acting downstream of estrogen and cooperatively with vitamin D. The possible association of a C 509-->T polymorphism in the promoter region of the transforming growth factor-beta1 gene, alone or in combination with a T869-->C (Leu10-->Pro) polymorphism, with bone mineral density and genetic susceptibility to osteoporosis was investigated in 625 postmenopausal Japanese women.
|
11357939 |
2001 |
|
rs1800470
|
|
Myocardial Ischemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Leu(10)-->Pro (codon 10) polymorphism in the TGF-beta1 gene is associated with end-stage heart failure caused by dilated CMP and not with IHD.
|
11557193 |
2001 |
|
rs1800470
|
|
End stage cardiac failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Leu(10)-->Pro (codon 10) polymorphism in the TGF-beta1 gene is associated with end-stage heart failure caused by dilated CMP and not with IHD.
|
11557193 |
2001 |
|
rs1800470
|
|
Cardiomyopathy, Dilated
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|
0.010 |
GeneticVariation
|
BEFREE |
The Leu(10)-->Pro (codon 10) polymorphism in the TGF-beta1 gene is associated with end-stage heart failure caused by dilated CMP and not with IHD.
|
11557193 |
2001 |
|
rs1800470
|
|
Diabetic Nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that TGF-beta1 T29C polymorphism is not associated with the progression of diabetic nephropathy.
|
11576951 |
2001 |
|
rs1800470
|
|
Osteoporosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
We have shown that a T869-->C polymorphism of the transforming growth factor-beta1 gene, which results in a Leu-->Pro substitution at amino acid 10, is associated with bone mineral density in Japanese adolescents and postmenopausal women, with genetic susceptibility to both osteoporosis and vertebral fracture, and with the outcome of treatment for osteoporosis with active vitamin D. We have also shown that a C-509-->T polymorphism in the promoter region of this gene is associated with both bone mineral density and the prevalence of osteoporosis in postmenopausal women.
|
11740340 |
2001 |
|
rs1800470
|
|
PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequencies of genotype combinations of the -800G/A, -509C/T, L10P, and R25P TGF-beta(1) polymorphisms were significantly different between the PDR and non-PDR groups (chi(2) = 37.83, df = 20, P < 10(-2)).
|
11992481 |
2002 |
|
rs1800470
|
|
Systemic Scleroderma
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results are different from a previous study in which the frequency of the T/T allele was high in SSc at T869C (Leu10Pro).
|
12207584 |
2002 |
|
rs1800470
|
|
Polycystic Kidney, Autosomal Dominant
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that the polymorphism at Arg25Pro of TGF-beta1 in the Korean population has an allele distribution different from that ofthe Western population and that the polymorphism at Leu10Pro of TGF-beta1 has no association with the renal progression in Korean ADPKD patients.
|
12572925 |
2003 |
|
rs1800470
|
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
In humans, a T-->C transition at nucleotide 29 in the region encoding the signal peptide sequence of the transforming growth factor (TGF)-beta(1), which results in a Leu-->Pro substitution at codon 10, has been associated with myocardial infarction.
|
12649573 |
2003 |
|
rs1800470
|
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we genotyped 284 unrelated, nondiabetic Swedish men born in 1944 to assess the impact of the Leu10Pro variant on obesity, including abdominal obesity, and estimates of insulin, glucose and lipid metabolism as well as blood pressure.
|
12649573 |
2003 |
|
rs1800470
|
|
Osteoporosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
TGF-beta1 is commonly associated with a single base change resulting in a Leu(10)-->Pro (T(869)-->C) polymorphism and is a genetic marker for susceptibility to osteoporosis.
|
12706579 |
2003 |
|
rs1800470
|
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Haplotype analysis revealed that the possession of [-509C > T; L10P] conferred a decreased likelihood of HCC (OR = 0.74; 95% CI, 0.59-0.93; P = 0.008).
|
12858019 |
2003 |
|
rs1800470
|
|
Hepatitis B
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the presence of the TGF-beta1 -509C > T promoter or of the L10P polymorphism, and the combination of both [-509C > T; L10P] as a haplotype were strongly associated with a reduced risk of HCC in patients with chronic HBV infection.
|
12858019 |
2003 |
|
rs1800470
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the TGFB1 L10P polymorphism is not associated with breast cancer risk.
|
14607332 |
2003 |
|
rs1800470
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the TGFB1 L10P polymorphism is not associated with breast cancer risk.
|
14607332 |
2003 |
|
rs1800470
|
|
Immune thrombocytopenic purpura
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results demonstrate that the frequency of TGF-beta1 gene 509 (C-->T), codon 25 (Arg-->Pro), and codon 10 (Leu-->Pro) polymorphisms and alleles do not play a role as a genetic risk factor in the development and clinical progress of ITP.
|
14608199 |
2003 |
|
rs1800470
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A T29C transition polymorphism in the TGFB1 gene has been associated with higher circulating TGF-beta1 levels, and inconsistently with breast cancer risk in three recent studies.
|
15006917 |
2004 |
|
rs1800470
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
A T29C transition polymorphism in the TGFB1 gene has been associated with higher circulating TGF-beta1 levels, and inconsistently with breast cancer risk in three recent studies.
|
15006917 |
2004 |
|
rs1800470
|
|
Hyperplastic Polyp
|
|
0.010 |
GeneticVariation
|
BEFREE |
Whereas adenoma risk did not vary by TGFbeta1 L10P genotype, these results suggest that the L10P variant allele may have a protective role in the development of colorectal hyperplastic polyps, possibly consistent with its role as an inhibitor of epithelial growths.
|
15020570 |
2004 |