rs11549465
|
|
Malignant neoplasm of prostate
|
|
0.060 |
GeneticVariation
|
BEFREE |
The current findings suggest that HIF1A P582S polymorphism correlates with urinary cancers risk in Caucasian population, while A588T polymorphism may increase the risk of urinary cancers in Asian population and prostate cancer.
|
23723982 |
2013 |
rs11549465
|
|
Malignant neoplasm of prostate
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our findings indicate that HIF1A rs11549465 polymorphism may not independently play a significant role in the occurrence of prostate cancer.
|
28415653 |
2017 |
rs11549465
|
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
Studies on HIF 1α C1772T (P582S) polymorphism revealed a genetic susceptibility to malignant tumors, however, the results were conflicting.
|
24576222 |
2014 |
rs11549465
|
|
Malignant neoplasm of prostate
|
|
0.060 |
GeneticVariation
|
BEFREE |
In previous studies, the C1772T (P582S) or the G1790A (A588T) polymorphisms of the HIF-1alpha gene have been identified in renal cell carcinoma, head and neck and esophageal squamous cell carcinomas as well as colorectal and prostate cancers.
|
18949419 |
2008 |
rs11549465
|
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
In conclusion, our findings suggest that HIF1A Pro582Ser</span> polymorphism may contribute to the risk of digestive tract cancers, especially in Asian populations.
|
25117331 |
2014 |
rs11549465
|
|
Malignant neoplasm of prostate
|
|
0.060 |
GeneticVariation
|
BEFREE |
The HIF1A +1772 C>T (rs11549465) polymorphism was genotyped, using DNA isolated from peripheral blood, in 1490 male subjects (754 with prostate cancer and 736 controls cancer-free) through Real-Time PCR.
|
24090974 |
2014 |
rs11549465
|
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
The P582S HIF-1alpha is a stable variant and HIF-1alpha mutation is a mechanism for enhancing HIF-1alpha activity in human cancer.
|
15538748 |
2005 |
rs11549465
|
|
Malignant neoplasm of prostate
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our data suggest that homozygous HIF1A P582S mutation confers significant susceptibility to prostate cancer.
|
16998808 |
2007 |
rs11549465
|
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
This meta-analysis aims to derive a precise estimation of the association between a common polymorphism (C1772T; rs11549465 C>T) in the HIF-1α gene and susceptibility to GIT cancer.
|
24063654 |
2013 |
rs11549465
|
|
Malignant neoplasm of prostate
|
|
0.060 |
GeneticVariation
|
BEFREE |
No altered PCa risk was associated with the rs11549465 and rs2057482 polymorphism.
|
23042446 |
2012 |
rs11549465
|
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our findings suggest that the HIF-1α A588T polymorphism is significantly associated with higher cancer risk and the P582S polymorphism is significantly associated with pancreatic cancer risk.
|
24293391 |
2014 |
rs11549465
|
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
These results suggest that <i>HIF-1α</i> rs11549465 C>T polymorphism may predispose to cancer susceptibility.
|
31762805 |
2019 |
rs11549465
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
The HIF1A +1772 C>T (rs11549465) polymorphism was genotyped, using DNA isolated from peripheral blood, in 1490 male subjects (754 with prostate cancer and 736 controls cancer-free) through Real-Time PCR.
|
24090974 |
2014 |
rs11549465
|
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
The P582S HIF-1alpha is a stable variant and HIF-1alpha mutation is a mechanism for enhancing HIF-1alpha activity in human cancer.
|
15538748 |
2005 |
rs11549465
|
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our findings suggest that the HIF-1α A588T polymorphism is significantly associated with higher cancer risk and the P582S polymorphism is significantly associated with pancreatic cancer risk.
|
24293391 |
2014 |
rs11549465
|
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
Subgroup analysis by ethnicity suggested that HIF1A Pro582Ser polymorphism might increase an individual's susceptibility to digestive tract cancer in Asian populations.
|
25117331 |
2014 |
rs11549465
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our findings indicate that HIF1A rs11549465 polymorphism may not independently play a significant role in the occurrence of prostate cancer.
|
28415653 |
2017 |
rs11549465
|
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis aims to derive a precise estimation of the association between a common polymorphism (C1772T; rs11549465 C>T) in the HIF-1α gene and susceptibility to GIT cancer.
|
24063654 |
2013 |
rs11549465
|
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
These results suggest that <i>HIF-1α</i> rs11549465 C>T polymorphism may predispose to cancer susceptibility.
|
31762805 |
2019 |
rs11549465
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
The current findings suggest that HIF1A P582S polymorphism correlates with urinary cancers risk in Caucasian population, while A588T polymorphism may increase the risk of urinary cancers in Asian population and prostate cancer.
|
23723982 |
2013 |
rs11549465
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our data suggest that homozygous HIF1A P582S mutation confers significant susceptibility to prostate cancer.
|
16998808 |
2007 |
rs11549465
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
No altered PCa risk was associated with the rs11549465 and rs2057482 polymorphism.
|
23042446 |
2012 |
rs763538721
|
|
melanoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The present study evaluated the effect of hypoxia on three BRAF-V600E mutant melanoma cell lines, M14, A375 and 518A2, treated with vemurafenib.
|
26936534 |
2016 |
rs763538721
|
|
melanoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
While under normoxic conditions the expression of glycolysis-related genes showed no correlation with origin or BRAF mutation status, GLUT1 expression was significantly elevated in metastatic and BRAF-V600E mutated melanoma cell lines under hypoxic conditions.
|
31791701 |
2020 |
rs763538721
|
|
melanoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
ETV1 expression is a rare event in human melanoma and seems to be rather based on hyperactivation of MAPK signals, by BRAF (V600E) mutation, than on ETV1 gene amplification.
|
25073704 |
2014 |