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rs10873142
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|
Chronic Obstructive Airway Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
To the best of our knowledge, this is the first case-control study uncovering that the <i>HIF1A</i> gene rs10873142 polymorphism increases the risk of COPD in a Chinese Han population.
|
29339421 |
2018 |
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rs11549465
|
|
Diabetic Retinopathy
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|
0.010 |
GeneticVariation
|
BEFREE |
We identified a protective effect of <i>HIF-1A</i> Pro582Ser against developing severe DR with a risk reduction of 95%, even when adjusting for known risk factors for DR such as diabetes duration, hyperglycemia, and hypertension.
|
31214621 |
2019 |
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rs11549465
|
|
Left Ventricular Hypertrophy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The distribution differences of gene frequencies for rs11549465, rs11549467 and rs1957757 in HIF1A single nucleotide gene polymorphisms for LVH (+) and LVH (-) were statistically significant (p<0.05).
|
31599436 |
2019 |
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rs11549465
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We identified a protective effect of <i>HIF-1A</i> Pro582Ser against developing severe DR with a risk reduction of 95%, even when adjusting for known risk factors for DR such as diabetes duration, hyperglycemia, and hypertension.
|
31214621 |
2019 |
|
rs11549465
|
|
Hyperglycemia
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|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, the relative resistance of the <i>HIF-1A</i> Pro582Ser polymorphism to the repressive effect of hyperglycemia is due to the transactivation activity rather than the protein stability of HIF-1<i>α</i>.
|
31214621 |
2019 |
|
rs11549465
|
|
Neural Tube Defects
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results of this study show that Hif-1α Pro582Ser and TGF-β3 IVS5+104 A/G SfaN1 polymorphisms may play a role in NTDs.
|
30672442 |
2018 |
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rs11549465
|
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay.
|
27981753 |
2017 |
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rs11549465
|
|
Chronic Obstructive Airway Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Patients with rs11549465 CT + TT had higher COPD risk than those with the CC genotype.
|
28865600 |
2017 |
|
rs11549465
|
|
Primary Sjögren's syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
We identified <i>HIF1A Pro582Ser T</i> allele and <i>C</i>/<i>T</i> genotype as well as <i>AKNA -1372C>A</i> polymorphism A/A genotype as genetic factors associated with pSS.
|
28484714 |
2017 |
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rs11549465
|
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay.
|
27981753 |
2017 |
|
rs11549465
|
|
Endometriosis
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|
0.010 |
GeneticVariation
|
BEFREE |
The associations between the presence of endometriosis and SNPs in PLGF (rs2268614), HIF-1α (rs11549465), and VEGFR1 (rs9582036) genes lost statistical significance after multiple testing.
|
26773192 |
2016 |
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rs11549465
|
|
Age related macular degeneration
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotype distribution of rs1061170 (CFH), rs429608 (SKIV2L), rs2679798 (MYRIP) and both rs11549465 and rs11549467 (HIF1A) in AMD cases and healthy controls; association between genotypes and AMD subtypes.
|
24995509 |
2015 |
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rs11549465
|
|
Degenerative polyarthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Gene frequencies exhibited a significant increase of the CC genotype of rs11549465 polymorphism in knee OA patients as compared with those present in controls (P = 0.003 OR = 5.7, 95% CI = 1.7-21.6); CT genotype and T allele showed decreased frequency in the knee OA group vs. the controls (P = 0.003 OR = 0.2, CI = 0.05-0.6; and P = 0.004 OR = 0.2, CI = 0.05-0.65, respectively).
|
26293784 |
2015 |
|
rs11549465
|
|
Foot Ulcer
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study was designed in order to examine the HIF-1α gene polymorphism, p582s (rs11549465) in Exon-12 of HIF-1α gene in diabetic subjects with and without foot ulcers (DFU) and to find its expression under these pathological conditions.
|
26113285 |
2015 |
|
rs11549465
|
|
Diabetic foot ulcer
|
|
0.010 |
GeneticVariation
|
BEFREE |
Impact of the hypoxia inducible factor-1α (HIF-1α) pro582ser polymorphism and its gene expression on diabetic foot ulcers.
|
26113285 |
2015 |
|
rs11549465
|
|
Malignant neoplasm of pancreas
|
|
0.010 |
GeneticVariation
|
BEFREE |
In subgroup analysis for cancer types, the two polymorphisms were only associated with increased risk of pancreatic cancer (P582S: SS vs. PP: OR = 2.51, 95% CI: 1.31, 4.81; SS vs.
|
24293391 |
2014 |
|
rs11549465
|
|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Hypoxia-inducible factor-1 alpha (HIF-1α) P582S polymorphism has been reported to increase transactivation capacity of HIF-1α, which is prone to tumorigenesis.
|
25337255 |
2014 |
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rs11549465
|
|
Tumor Progression
|
|
0.010 |
GeneticVariation
|
BEFREE |
Hypoxia-inducible factor-1 (HIF-1) influences cancer progression and metastasis through various mechanisms, and HIF-1α polymorphisms are reportedly associated with many cancers; however, the associations of HIF-1α P582S and A588T polymorphisms with the risk of digestive system cancer remain inconclusive.
|
24293391 |
2014 |
|
rs11549465
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In subgroup analysis for cancer types, the two polymorphisms were only associated with increased risk of pancreatic cancer (P582S: SS vs. PP: OR = 2.51, 95% CI: 1.31, 4.81; SS vs.
|
24293391 |
2014 |
|
rs11549465
|
|
Cancer of Digestive System
|
|
0.010 |
GeneticVariation
|
BEFREE |
HIF-1α P582S and A588T polymorphisms and digestive system cancer risk-a meta-analysis.
|
24293391 |
2014 |
|
rs11549465
|
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
It is worth mentioning that the allele T at rs11549465, located at the exon sequence, revealed a trend but no significant difference towards the more frequent allele T in SLE than in controls (C versus T: OR=1.206, 95 % CI=0.972-1.495, p =0.088).
|
24232601 |
2014 |
|
rs11549465
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
HIF-1a rs11549465 and rs115494657 polymorphisms appeared to be irrelevant to HBV-related HCC.
|
25195037 |
2014 |
|
rs11549465
|
|
Hepatitis B
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two polymorphisms in the HIF-1a gene (rs11549465 and rs115494657) were examined in 157 hepatitis B virus (HBV)-related HCC patients and 173 healthy controls using the polymerase chain reaction-restriction fragment length polymorphism method.
|
25195037 |
2014 |
|
rs11549465
|
|
Anemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings show for the first time that the HIF-1α(Pro-582-Ser) polymorphism significantly affects red blood cell and iron homeostasis after blood loss, conferring to male carriers a resistance to anaemia.
|
24120591 |
2013 |
|
rs11549465
|
|
Iron deficiency
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, the HIF-1α(Pro-582-Ser) polymorphism protected regular blood donors from developing iron deficiency and anaemia and predicted uninterrupted donation activity.
|
24120591 |
2013 |