Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1053004
rs1053004
STAT3
CUI: C0524587
Disease: Mean Corpuscular Volume (result)
Mean Corpuscular Volume (result) 		A 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252

2016
dbSNP: rs1053004
rs1053004
STAT3
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.040 GeneticVariation BEFREE <b>Conclusions:</b> The meta-analysis showed that <i>STAT3</i> rs1053004 polymorphism may be the risk for developing chronic HBV infection but not associated with HCC. 31160486

2019
dbSNP: rs1053004
rs1053004
STAT3
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.040 GeneticVariation BEFREE In multivariate regression analyses, multiplicative interaction of rs1053004 with T1674C/G significantly increased HCC risk, whereas rs2293152 and A1726C interaction reduced it, adjusting for covariates including HBV mutations in the enhancer II/basal core promoter/precore region; the interaction of rs4796793 with preS2 start codon mutation significantly increased HCC risk, adjusting for covariates including HBV mutations in the preS region. 23386590

2013
dbSNP: rs1053004
rs1053004
STAT3
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.040 GeneticVariation BEFREE These findings suggest that the SNP rs1053004 in STAT3 might contribute to HCC susceptibility and could be used as a genetic marker for HCC in the Thai population. 26163643

2015
dbSNP: rs1053004
rs1053004
STAT3
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.040 GeneticVariation BEFREE These results illustrate that perhaps rs1053004 polymorphisms in the STAT3 gene participated in the progression of hepatitis B to HCC in Iranian people. 29307341

2017
dbSNP: rs1053004
rs1053004
STAT3
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.030 GeneticVariation BEFREE These results illustrate that perhaps rs1053004 polymorphisms in the STAT3 gene participated in the progression of hepatitis B to HCC in Iranian people. 29307341

2017
dbSNP: rs1053004
rs1053004
STAT3
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.030 GeneticVariation BEFREE <b>Conclusions:</b> The meta-analysis showed that <i>STAT3</i> rs1053004 polymorphism may be the risk for developing chronic HBV infection but not associated with HCC. 31160486

2019
dbSNP: rs1053004
rs1053004
STAT3
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.030 GeneticVariation BEFREE STAT3 rs1053004 and rs1053005 polymorphisms and haplotypes formed by rs1053004 and rs1053005 are associated with chronic HBV infection and the haplotypes appear to be also associated with the development of liver disease. 29609539

2018
dbSNP: rs1053004
rs1053004
STAT3
CUI: C0524909
Disease: Hepatitis B, Chronic
Hepatitis B, Chronic 		0.020 GeneticVariation BEFREE Evaluation of STAT3 rs1053004 single nucleotide polymorphism in patients with chronic hepatitis B and hepatocellular carcinoma. 29307341

2017
dbSNP: rs1053004
rs1053004
STAT3
CUI: C0151517
Disease: Complete atrioventricular block
Complete atrioventricular block 		0.020 GeneticVariation BEFREE The genotype of SNP rs1053004 (CC versus TT+TC) was significantly associated with an increased risk when compared with CHB patients (OR=1.83, 95% CI=1.13-2.99, P=0.015). 26163643

2015
dbSNP: rs1053004
rs1053004
STAT3
CUI: C0151517
Disease: Complete atrioventricular block
Complete atrioventricular block 		0.020 GeneticVariation BEFREE The purpose of this research is to evaluate the single nucleotide polymorphism (SNP) rs1053004 in the STAT3 gene in CHB patients and individuals who suffer from HCC. 29307341

2017
dbSNP: rs1053004
rs1053004
STAT3
CUI: C0524909
Disease: Hepatitis B, Chronic
Hepatitis B, Chronic 		0.020 GeneticVariation BEFREE Association of Single Nucleotide Polymorphism rs1053004 in Signal Transducer and Activator of Transcription 3 (STAT3) with Susceptibility to Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B. 26163643

2015
dbSNP: rs1053004
rs1053004
STAT3
CUI: C4721579
Disease: Secondary malignant neoplasm of colon and/or rectum
Secondary malignant neoplasm of colon and/or rectum 		0.010 GeneticVariation BEFREE Association of <i>STAT</i>-3 rs1053004 and <i>VDR</i> rs11574077 With FOLFIRI-Related Gastrointestinal Toxicity in Metastatic Colorectal Cancer Patients. 29706892

2018
dbSNP: rs1053004
rs1053004
STAT3
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.010 GeneticVariation BEFREE In conclusion, the current study provided evidence that rs1053004 T > C in 3'UTR of STAT3 may decrease the risk of PC through up-regulating the gene expression. 27577070

2016
dbSNP: rs1053004
rs1053004
STAT3
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.010 GeneticVariation BEFREE STAT3 rs1053004 and rs1053005 polymorphisms and haplotypes formed by rs1053004 and rs1053005 are associated with chronic HBV infection and the haplotypes appear to be also associated with the development of liver disease. 29609539

2018
dbSNP: rs1053004
rs1053004
STAT3
CUI: C0349566
Disease: Squamous cell carcinoma of tongue
Squamous cell carcinoma of tongue 		0.010 GeneticVariation BEFREE The expression level of STAT3 protein in tumor tissues of patients with <i>STAT3</i> rs1053004 locus GG genotype was significantly higher than in patients with type GA, and it was the lowest in patients with type AA.<b>Conclusion:</b> Polymorphisms in the <i>SP1</i> rs1353058818 and <i>STAT3</i> rs1053004 loci are associated with the risk of human TSCC. 31270251

2019
dbSNP: rs1053004
rs1053004
STAT3
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 GeneticVariation BEFREE The expression level of STAT3 protein in tumor tissues of patients with <i>STAT3</i> rs1053004 locus GG genotype was significantly higher than in patients with type GA, and it was the lowest in patients with type AA.<b>Conclusion:</b> Polymorphisms in the <i>SP1</i> rs1353058818 and <i>STAT3</i> rs1053004 loci are associated with the risk of human TSCC. 31270251

2019
dbSNP: rs1053004
rs1053004
STAT3
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.010 GeneticVariation BEFREE In conclusion, the current study provided evidence that rs1053004 T > C in 3'UTR of STAT3 may decrease the risk of PC through up-regulating the gene expression. 27577070

2016
dbSNP: rs1053005
rs1053005
STAT3
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.010 GeneticVariation BEFREE STAT3 rs1053004 and rs1053005 polymorphisms and haplotypes formed by rs1053004 and rs1053005 are associated with chronic HBV infection and the haplotypes appear to be also associated with the development of liver disease. 29609539

2018
dbSNP: rs1053005
rs1053005
STAT3
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.010 GeneticVariation BEFREE STAT3 rs1053004 and rs1053005 polymorphisms and haplotypes formed by rs1053004 and rs1053005 are associated with chronic HBV infection and the haplotypes appear to be also associated with the development of liver disease. 29609539

2018
dbSNP: rs1053005
rs1053005
STAT3
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.010 GeneticVariation BEFREE We first explored the associations between two common variants (rs1053004 and rs1053005) and PC risk in 774 PC cases and 777 controls. 27577070

2016
dbSNP: rs1053005
rs1053005
STAT3
CUI: C0028754
Disease: Obesity
Obesity 		0.010 GeneticVariation BEFREE GG genotype at rs1053005 had lower risks of both general obesity and central obesity (OR=0.40, p=0.034; OR=0.42, p=0.007, respectively) compared with AA genotype. 25014397

2014
dbSNP: rs1053005
rs1053005
STAT3
CUI: C0524909
Disease: Hepatitis B, Chronic
Hepatitis B, Chronic 		0.010 GeneticVariation BEFREE Association of polymorphism rs1053005 in STAT3 with chronic hepatitis B virus infection in Han Chinese population. 29609539

2018
dbSNP: rs1053005
rs1053005
STAT3
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease 		0.010 GeneticVariation BEFREE The allele A from rs1053005 was significantly less frequent in both GD and HT patients (P = 0.0024, OR = 0.6958, 95%CI = 0.5508-0.8788; P = 0.0091, OR = 0.7013, 95%CI = 0.5397-0.9112, respectively). 24081513

2013
dbSNP: rs1053005
rs1053005
STAT3
CUI: C3840565
Disease: Autoimmune thyroid disease (AITD)
Autoimmune thyroid disease (AITD) 		0.010 GeneticVariation BEFREE The allele A and AA genotype of SNP rs1053005 may protect individuals from the susceptibility to AITD and their frequency decreased in AITD patients. 24081513

2013