|
rs744166
|
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
The presence of (C) in rs10758669, (T) and (TT) in rs957970, and (TT) in rs744166 were found to increase the susceptibility to Crohn's disease (p=0.049, p=0.016, p=0.010, p=0.035, respectively), while rs2293152 (GC), rs744166 (CT), and rs957970 (CT) provide protection against Crohn's disease (p=0.007, p=0.043, p=0.043, respectively).
|
27852544 |
2016 |
|
rs744166
|
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
Our results support an important association of rs744166 and rs4796793 with decreased CD risk, and additional interaction between rs744166 and smoking.
|
27022745 |
2016 |
|
rs744166
|
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that carriers of the STAT3 rs744166 'A' allele have a significantly greater risk of CD and UC, especially among Caucasians.
|
25286337 |
2014 |
|
rs744166
|
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
STAT3 rs744166 and rs4796793 polymorphisms may be associated with CD occurrence and used as a predictive factor of CD in Chinese Han populations.
|
24885273 |
2014 |
|
rs744166
|
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
Here, we studied the susceptibility nature of three components of IL23 signalling and Th17 cell differentiation: JAK2 rs10758669, STAT3 rs744166 and CCR6 rs2301436 initially associated with CD in Hungarian CD and UC patients.
|
22269120 |
2012 |
|
rs744166
|
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
JAK2 rs10758669 and STAT3 rs744166 increase susceptibility for CD.
|
22065112 |
2012 |
|
rs744166
|
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
Allelic association analysis (two-tailed) showed that three of the five targeted SNPs were significantly associated with overall susceptibility for CD (ZNF365, r10995271, P = 0.001; PTPN2, rs1893217, P = 0.005; STAT3, rs744166, P = 0.01).
|
20222910 |
2010 |
|
rs744166
|
|
Crohn Disease
|
A |
0.870 |
GeneticVariation
|
GWASCAT |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
rs744166
|
|
Crohn Disease
|
A |
0.870 |
GeneticVariation
|
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
rs744166
|
|
Multiple Sclerosis
|
|
0.820 |
GeneticVariation
|
BEFREE |
We observed a nominally significant, albeit weak association between rs744166 and MS susceptibility (odds ratio = 1.09, P = 0.012) in our sample.
|
22095036 |
2012 |
|
rs744166
|
|
Multiple Sclerosis
|
G |
0.820 |
GeneticVariation
|
GWASCAT |
SNP (rs744166) within the STAT3 gene was associated to MS (p = 2.75 x 10(-10), OR 0.87, confidence interval 0.83-0.91).
|
20159113 |
2010 |
|
rs744166
|
|
Multiple Sclerosis
|
G |
0.820 |
GeneticVariation
|
GWASDB |
SNP (rs744166) within the STAT3 gene was associated to MS (p = 2.75 x 10(-10), OR 0.87, confidence interval 0.83-0.91).
|
20159113 |
2010 |
|
rs744166
|
|
Multiple Sclerosis
|
|
0.820 |
GeneticVariation
|
BEFREE |
SNP (rs744166) within the STAT3 gene was associated to MS (p = 2.75 x 10(-10), OR 0.87, confidence interval 0.83-0.91).
|
20159113 |
2010 |
|
rs9891119
|
|
Crohn Disease
|
A |
0.810 |
GeneticVariation
|
GWASDB |
We confirmed associations of Crohn's disease with variants in MHC (rs7765379, P = 2.11 × 10(-59)), TNFSF15 (rs6478106, P = 3.87 × 10(-45)), and STAT3 (rs9891119, P = 2.24 × 10(-14)).
|
23266558 |
2013 |
|
rs9891119
|
|
Crohn Disease
|
|
0.810 |
GeneticVariation
|
BEFREE |
We confirmed associations of Crohn's disease with variants in MHC (rs7765379, P = 2.11 × 10(-59)), TNFSF15 (rs6478106, P = 3.87 × 10(-45)), and STAT3 (rs9891119, P = 2.24 × 10(-14)).
|
23266558 |
2013 |
|
rs9891119
|
|
Crohn Disease
|
A |
0.810 |
GeneticVariation
|
GWASCAT |
We confirmed associations of Crohn's disease with variants in MHC (rs7765379, P = 2.11 × 10(-59)), TNFSF15 (rs6478106, P = 3.87 × 10(-45)), and STAT3 (rs9891119, P = 2.24 × 10(-14)).
|
23266558 |
2013 |
|
rs12942547
|
|
Inflammatory Bowel Diseases
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
rs12942547
|
|
Inflammatory Bowel Diseases
|
G |
0.800 |
GeneticVariation
|
GWASCAT |
Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans.
|
27569725 |
2016 |
|
rs12942547
|
|
Inflammatory Bowel Diseases
|
A |
0.800 |
GeneticVariation
|
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
rs12942547
|
|
Inflammatory Bowel Diseases
|
A |
0.800 |
GeneticVariation
|
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
rs193922721
|
|
HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Functional characterization of two new STAT3 mutations associated with hyper-IgE syndrome in a Mexican cohort.
|
26293184 |
2016 |
|
rs193922721
|
|
HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT
|
C |
0.800 |
GeneticVariation
|
CLINVAR |
Lung parenchyma surgery in autosomal dominant hyper-IgE syndrome.
|
23584561 |
2013 |
|
rs193922721
|
|
HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT
|
C |
0.800 |
GeneticVariation
|
CLINVAR |
Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey.
|
22751495 |
2012 |
|
rs193922721
|
|
HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Signal transducer and activator of transcription 3 mutation with invasive eosinophilic disease.
|
23342295 |
2012 |
|
rs193922721
|
|
HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT
|
C |
0.800 |
GeneticVariation
|
CLINVAR |
Defects along the T(H)17 differentiation pathway underlie genetically distinct forms of the hyper IgE syndrome.
|
19577286 |
2009 |