|
rs1805087
|
|
Neural Tube Defects
|
|
0.090 |
GeneticVariation
|
BEFREE |
The D919G mutation does not seem to be a risk factor for NTD or vascular disease.
|
9327029 |
1997 |
|
rs1805087
|
|
Vascular Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
The D919G mutation does not seem to be a risk factor for NTD or vascular disease.
|
9327029 |
1997 |
|
rs1805087
|
|
Adenoma of large intestine
|
|
0.050 |
GeneticVariation
|
BEFREE |
We also examined the relationship of a newly identified polymorphism (asp919gly) of the methionine synthase gene (MS) with the risk of colorectal adenomas in the same population.
|
9886567 |
1998 |
|
rs1805087
|
|
Vascular Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Thus, the methionine synthase D919G mutation was found to be common in the Japanese general population, and it appears unlikely that this polymorphism has a major effect on homocysteine metabolism and/or the onset of vascular diseases.
|
9974410 |
1999 |
|
rs1805087
|
|
Coronary Artery Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
Methyltetrahydrofolate reductase (MTHFR) 677C-->T, cystathionine beta synthase (CBS) 68-bp insertion at exon 8, and methionine synthase (MS) 2756A-->G were typed in 685 Australian caucasian patients aged < or =65 years with and without angiographically documented coronary artery disease (CAD).
|
10487496 |
1999 |
|
rs1805087
|
|
Colorectal Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
In this study, we examined the relationship of a polymorphism (2756A-->G, asp-->gly) in the gene (MTR) for methionine synthase, another important enzyme in the same folate/methionine/homocyst(e)ine metabolic pathway, with risk of colorectal cancer among 356 cases and 476 cancer-free controls.
|
10498402 |
1999 |
|
rs1805087
|
|
Malignant neoplasm of colon and/or rectum
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study, we examined the relationship of a polymorphism (2756A-->G, asp-->gly) in the gene (MTR) for methionine synthase, another important enzyme in the same folate/methionine/homocyst(e)ine metabolic pathway, with risk of colorectal cancer among 356 cases and 476 cancer-free controls.
|
10498402 |
1999 |
|
rs1805087
|
|
Venous Thromboembolism
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequencies of Factor V G1691A (FVL), prothrombin (PT) G20210A, 5'10'methylenetetrahydrofolate reductase (MTHFR) C677T, and methionine synthase (MS) A2756G (four mutations associated with an increased risk of venous thromboembolism [VTE]) were determined in a sample of approximately 1500 New York State residents.
|
10963782 |
2000 |
|
rs1805087
|
|
Myocardial Infarction
|
|
0.050 |
GeneticVariation
|
BEFREE |
Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction.
|
11257268 |
2001 |
|
rs1805087
|
|
Kidney Failure, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
To evaluate the respective roles of residual glomerular filtration (by measuring a specific protein marker, cystatin C), genetic polymorphisms and nutritional status in tHcy blood levels in end-stage renal disease patients (ESRD) under hemodialysis and supplemented with folate, we measured tHcy, folate, vitamin B12 (B12), creatinine, cystatin C, albumin and C-reactive protein and determined the polymorphism of methylenetetrahydrofolate reductase (MTHFR) (C677T and A1289C) and of methionine synthase (MS) (A2756G) in 114 ESRD patients before hemodialysis and 76 control subjects.
|
11592445 |
2001 |
|
rs1805087
|
|
Chronic kidney disease stage 5
|
|
0.010 |
GeneticVariation
|
BEFREE |
To evaluate the respective roles of residual glomerular filtration (by measuring a specific protein marker, cystatin C), genetic polymorphisms and nutritional status in tHcy blood levels in end-stage renal disease patients (ESRD) under hemodialysis and supplemented with folate, we measured tHcy, folate, vitamin B12 (B12), creatinine, cystatin C, albumin and C-reactive protein and determined the polymorphism of methylenetetrahydrofolate reductase (MTHFR) (C677T and A1289C) and of methionine synthase (MS) (A2756G) in 114 ESRD patients before hemodialysis and 76 control subjects.
|
11592445 |
2001 |
|
rs1805087
|
|
Coronary Artery Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our results suggest that neither single mutation nor combined mutations in MTHFR C677T, CBS 844ins68 and MS A2756G represent an independent risk factor for increasing IS and coronary artery disease risks in Chinese population.
|
11672761 |
2001 |
|
rs1805087
|
|
Coronary heart disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our results suggest that neither single mutation nor combined mutations in MTHFR C677T, CBS 844ins68 and MS A2756G represent an independent risk factor for increasing IS and coronary artery disease risks in Chinese population.
|
11672761 |
2001 |
|
rs1805087
|
|
Myocardial Infarction
|
|
0.050 |
GeneticVariation
|
BEFREE |
The G allele of MS A2756G yields an OR of 0.92(95% CI 0.47-1.81) for IS and 1.17 (95% CI 0.58-2.37) for MI.
|
11672761 |
2001 |
|
rs1805087
|
|
Coronary Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results suggest that neither single mutation nor combined mutations in MTHFR C677T, CBS 844ins68 and MS A2756G represent an independent risk factor for increasing IS and coronary artery disease risks in Chinese population.
|
11672761 |
2001 |
|
rs1805087
|
|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results suggest that neither single mutation nor combined mutations in MTHFR C677T, CBS 844ins68 and MS A2756G represent an independent risk factor for increasing IS and coronary artery disease risks in Chinese population.
|
11672761 |
2001 |
|
rs1805087
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
Polymorphisms in methionine synthase (MS A2756G), cytosolic serine hydroxymethyltransferase (SHMT1 C1420T), and a double (2R2R) or triple (3R3R) 28-bp tandem repeat in the promoter region of thymidylate synthase (TS) were studied and found to modulate ALL risk.
|
11986237 |
2002 |
|
rs1805087
|
|
Hyperhomocysteinemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Mutations in methylenetetrahydrofolate reductase (C667T), cystathionine beta-synthase (T833C), and methionine synthase (A2756G) genes cause hyperhomocysteinemia, an independent risk factor for atherothrombosis.
|
12476935 |
2002 |
|
rs1805087
|
|
Atherothrombosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Mutations in methylenetetrahydrofolate reductase (C667T), cystathionine beta-synthase (T833C), and methionine synthase (A2756G) genes cause hyperhomocysteinemia, an independent risk factor for atherothrombosis.
|
12476935 |
2002 |
|
rs1805087
|
|
Lymphoma, Non-Hodgkin
|
|
0.040 |
GeneticVariation
|
BEFREE |
We analysed genetic polymorphisms for methionine synthase (MS) A2756G, methylenetetrahydrofolate reductase (MTHFR) C677T and MTHFR A1298C in Caucasians with non-Hodgkin's lymphoma (NHL; n = 151), multiple myeloma (MM; n = 90) and 299 control subjects.
|
12648076 |
2003 |
|
rs1805087
|
|
Multiple Myeloma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We analysed genetic polymorphisms for methionine synthase (MS) A2756G, methylenetetrahydrofolate reductase (MTHFR) C677T and MTHFR A1298C in Caucasians with non-Hodgkin's lymphoma (NHL; n = 151), multiple myeloma (MM; n = 90) and 299 control subjects.
|
12648076 |
2003 |
|
rs1805087
|
|
B-Cell Lymphomas
|
|
0.010 |
GeneticVariation
|
BEFREE |
Methionine synthase genetic polymorphism MS A2756G alters susceptibility to follicular but not diffuse large B-cell non-Hodgkin's lymphoma or multiple myeloma.
|
12648076 |
2003 |
|
rs1805087
|
|
Neural Tube Defects
|
|
0.090 |
GeneticVariation
|
BEFREE |
We detected MTR A2756G and MTRR A66G polymorphisms using PCR-RFLP analysis in a group of NTD infants, their mothers and normal controls.
|
12649067 |
2003 |
|
rs1805087
|
|
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study reports the influence of folate status, DNA methylation, and polymorphisms of methylenetetrahydrofolate reductase (MTHFR 677C-->T and 1298A-->C), methionine synthase (MS 2756A-->G), and cystathionine-beta-synthase (CBS 844ins68) on risk for developing colorectal neoplasia.
|
12730865 |
2003 |
|
rs1805087
|
|
Alzheimer's Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
To assess whether the MS A2756G polymorphism holds any influence on AD risk, we have analyzed 172 AD patients and 166 controls.
|
12876480 |
2003 |