|
rs375328708
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
One silent change, C1257T, was found in a pancreatic carcinoma sample.
|
10079245 |
1999 |
|
rs199769221
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A relevant contribution of the Arg117His-mutation to pathogenesis of pancreatic cancer might be possible, since also asymptomatic individuals have been reported to carry this mutation and individuals with only mild symptoms may be undiagnosed as hp.
|
11062709 |
2000 |
|
rs17107315
|
|
Pancreatic carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The N34S mutation of SPINK1 appears not to be a distinct genetic risk factor in patients with sporadic pancreatic cancer.
|
12649567 |
2003 |
|
rs17107315
|
|
Pancreatic carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The frequencies of the promotor polymorphisms of IL10-627A, IL10-1117A, TNF-238A and TNF-308A in patients with alcoholic chronic pancreatitis, idiopathic pancreatitis, SPINK1-N34S-associated chronic pancreatitis and pancreatic cancer did not differ significantly from the control group.
|
14560157 |
2003 |
|
rs1223231582
|
|
Pancreatic carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The frequencies of the promotor polymorphisms of IL10-627A, IL10-1117A, TNF-238A and TNF-308A in patients with alcoholic chronic pancreatitis, idiopathic pancreatitis, SPINK1-N34S-associated chronic pancreatitis and pancreatic cancer did not differ significantly from the control group.
|
14560157 |
2003 |
|
rs104894094
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
As compared with the general population, the risk of pancreatic cancer (PC) was increased 9.4-fold [95% confidence interval (CI) 2.7-33.4] and 2.2-fold (95% CI 0.8-5.7) in G101W-positive and -negative MF, respectively, while mean ages at onset were 61 and 77 years, respectively.
|
14679123 |
2004 |
|
rs121913529
|
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
We find that physiological levels of Kras(G12D) induce ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs), putative precursors to invasive pancreatic cancer.
|
14706336 |
2003 |
|
rs762846821
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Using the whole-cell recording mode of the patch-clamp technique, functional ion channels were electrophysiologically characterized in PANC-1 (K-ras G12D (+/-), p53 R273C, Deltap16), BxPC-3 (smad4-, p53 Y220C, Deltap16), and MiaPaCa-2 [transforming growth factor-beta receptor type II defect, K-ras G12C(-/-), p53 R248W, Deltap16] human pancreatic cancer cell lines.
|
14978241 |
2004 |
|
rs121912651
|
|
Pancreatic carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Using the whole-cell recording mode of the patch-clamp technique, functional ion channels were electrophysiologically characterized in PANC-1 (K-ras G12D (+/-), p53 R273C, Deltap16), BxPC-3 (smad4-, p53 Y220C, Deltap16), and MiaPaCa-2 [transforming growth factor-beta receptor type II defect, K-ras G12C(-/-), p53 R248W, Deltap16] human pancreatic cancer cell lines.
|
14978241 |
2004 |
|
rs121913343
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using the whole-cell recording mode of the patch-clamp technique, functional ion channels were electrophysiologically characterized in PANC-1 (K-ras G12D (+/-), p53 R273C, Deltap16), BxPC-3 (smad4-, p53 Y220C, Deltap16), and MiaPaCa-2 [transforming growth factor-beta receptor type II defect, K-ras G12C(-/-), p53 R248W, Deltap16] human pancreatic cancer cell lines.
|
14978241 |
2004 |
|
rs121912666
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using the whole-cell recording mode of the patch-clamp technique, functional ion channels were electrophysiologically characterized in PANC-1 (K-ras G12D (+/-), p53 R273C, Deltap16), BxPC-3 (smad4-, p53 Y220C, Deltap16), and MiaPaCa-2 [transforming growth factor-beta receptor type II defect, K-ras G12C(-/-), p53 R248W, Deltap16] human pancreatic cancer cell lines.
|
14978241 |
2004 |
|
rs17107315
|
|
Pancreatic carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
To our knowledge, this is the first reported case of chronic pancreatitis accompanied by pancreatic cancer in a patient with the SPINK1 N34S mutation.
|
15084977 |
2004 |
|
rs1223231582
|
|
Pancreatic carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
To our knowledge, this is the first reported case of chronic pancreatitis accompanied by pancreatic cancer in a patient with the SPINK1 N34S mutation.
|
15084977 |
2004 |
|
rs111966833
|
|
Pancreatic carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The N34S and P55S mutations were determined by PCR amplification followed by solid-phase minisequencing in 116 patients with CP and in 188 with pancreatic cancer.
|
15764155 |
2005 |
|
rs397507444
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
We found that the C667T (but not the A1298C) polymorphism had a significant main effect on the risk of pancreatic cancer.
|
15941958 |
2005 |
|
rs74315364
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Glu265X mutation was identified in one (2.8%) familial and one (1.3%) sporadic pancreatic cancer case, but not in any of the controls.
|
15981205 |
2005 |
|
rs486907
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In familial pancreatic cancer no association between Arg462Gln genotypes and pancreatic cancer risk was evident.
|
15981205 |
2005 |
|
rs1217691063
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Joint effect between MTHFR C677T polymorphism and smoking or drinking increased risk of pancreatic cancer in a super-multiplicative manner.
|
16234002 |
2005 |
|
rs397507444
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
First, we performed a case-control study of germline MTHFR polymorphisms (C677T, A1298C) in 303 patients with pancreatic cancer and 305 matched control subjects.
|
16234003 |
2005 |
|
rs13181
|
|
Pancreatic carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk.
|
16458430 |
2007 |
|
rs1799793
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated the association between the XPD exon 10 Asp(312)Asn and exon 23 Lys(751)Gln polymorphisms and the risk of pancreatic cancer in a hospital-based study of 344 patients and 386 controls frequency matched by age, gender, and race.
|
16458430 |
2007 |
|
rs1799782
|
|
Pancreatic carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
We investigated the association between polymorphisms of MGMT (Leu(84)Phe and Ile(143)Val), APE1 (Asp(148)Glu), and XRCC1 (Arg(194)Trp and Arg(399)Gln) and risk of pancreatic cancer in a case-control study.
|
16844323 |
2006 |
|
rs25487
|
|
Pancreatic carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
We investigated the association between polymorphisms of MGMT (Leu(84)Phe and Ile(143)Val), APE1 (Asp(148)Glu), and XRCC1 (Arg(194)Trp and Arg(399)Gln) and risk of pancreatic cancer in a case-control study.
|
16844323 |
2006 |
|
rs2308321
|
|
Pancreatic carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated the association between polymorphisms of MGMT (Leu(84)Phe and Ile(143)Val), APE1 (Asp(148)Glu), and XRCC1 (Arg(194)Trp and Arg(399)Gln) and risk of pancreatic cancer in a case-control study.
|
16844323 |
2006 |
|
rs12917
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the association between polymorphisms of MGMT (Leu(84)Phe and Ile(143)Val), APE1 (Asp(148)Glu), and XRCC1 (Arg(194)Trp and Arg(399)Gln) and risk of pancreatic cancer in a case-control study.
|
16844323 |
2006 |