rs4961
|
|
Endothelial dysfunction
|
|
0.010 |
GeneticVariation
|
BEFREE |
Since inflammatory mechanisms may be involved in pathophysiology of hypertension and in endothelial dysfunction and atherosclerosis through reactive oxygen species, the baseline urinary excretion of inflammatory and oxidative stress markers in a subgroup of adolescents stratified according to <i>ADD1</i>(alpha adducin) rs4961 genotypes was assessed.
|
31760884 |
2020 |
rs876657421
|
|
Endothelial dysfunction
|
|
0.020 |
GeneticVariation
|
BEFREE |
Tg-I278T Cbs(-/-) mice exhibited severe hyperhomocysteinemia and endothelial dysfunction in cerebral arterioles.
|
22186991 |
2012 |
rs876657421
|
|
Endothelial dysfunction
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that, compared with untreated I278T mice, OT-58 treatment of I278T mice fed with the REG diet resulted in a 90% decrease in plasma Hcy concentrations and correction of learning/cognition, endothelial dysfunction, hemostasis, bone mineralization, and body composition.
|
31450979 |
2019 |
rs5742905
|
|
Endothelial dysfunction
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that, compared with untreated I278T mice, OT-58 treatment of I278T mice fed with the REG diet resulted in a 90% decrease in plasma Hcy concentrations and correction of learning/cognition, endothelial dysfunction, hemostasis, bone mineralization, and body composition.
|
31450979 |
2019 |
rs5742905
|
|
Endothelial dysfunction
|
|
0.020 |
GeneticVariation
|
BEFREE |
Tg-I278T Cbs(-/-) mice exhibited severe hyperhomocysteinemia and endothelial dysfunction in cerebral arterioles.
|
22186991 |
2012 |
rs3732378
|
|
Endothelial dysfunction
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to search for an association between V249I and T280M polymorphisms of CX3CR1, preeclampsia and endothelial dysfunction.
|
19587779 |
2009 |
rs3848403
|
|
Endothelial dysfunction
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of our study was to evaluate an association of FN3K (rs1056534, rs3848403) and GLO1 rs4746 polymorphisms with parameters of endothelial dysfunction and soluble receptor for AGEs (sRAGE) in 595 diabetic and non-diabetic subjects.
|
24908234 |
2014 |
rs772155434
|
|
Endothelial dysfunction
|
|
0.010 |
GeneticVariation
|
BEFREE |
The purpose of this study was to determine whether the gene variant in the HBD of ECSOD (ECSOD(R213G)) protects against endothelial dysfunction in a model of inflammation.
|
17717013 |
2007 |
rs4746
|
|
Endothelial dysfunction
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of our study was to evaluate an association of FN3K (rs1056534, rs3848403) and GLO1 rs4746 polymorphisms with parameters of endothelial dysfunction and soluble receptor for AGEs (sRAGE) in 595 diabetic and non-diabetic subjects.
|
24908234 |
2014 |
rs5443
|
|
Endothelial dysfunction
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the study was to examine the association between the G protein β3 subunit C825T polymorphism, associated with cardiovascular risk factors like hypertension (HT) and obesity and microalbuminuria (MA), reflecting the endothelial dysfunction in the atherosclerotic process.
|
20577224 |
2010 |
rs57920071
|
|
Endothelial dysfunction
|
|
0.010 |
GeneticVariation
|
BEFREE |
These data suggest that farnesylated p.R482W-prelamin-A accumulation at the nuclear envelope is a toxic event, leading to cellular oxidative stress and endothelial dysfunction.
|
23846499 |
2013 |
rs9818870
|
|
Endothelial dysfunction
|
|
0.010 |
GeneticVariation
|
BEFREE |
The augmented endothelium-dependent vasodilation of the forearm resistance vasculature does not support the presence of endothelial dysfunction in young SNP carriers and indicates that other mechanisms are responsible for the strong association between coronary artery diseases and the rs9818870 polymorphism, located on 3q22.3.
|
26284284 |
2015 |
rs1217691063
|
|
Endothelial dysfunction
|
|
0.070 |
GeneticVariation
|
BEFREE |
Also, no association between the MTHFR 677 C>T polymorphism and CV events or endothelial dysfunction was observed.
|
20423475 |
2010 |
rs1217691063
|
|
Endothelial dysfunction
|
|
0.070 |
GeneticVariation
|
BEFREE |
Angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms are linked to endothelial dysfunction and to cerebral white matter lesions.
|
19298544 |
2009 |
rs1217691063
|
|
Endothelial dysfunction
|
|
0.070 |
GeneticVariation
|
BEFREE |
It was aimed to explain the association of the endothelial dysfunction, which is thought to play a role in the pathophysiology of CSX, with C677T polymorphism on MTHFR gene based on genetic basis.
|
28481466 |
2018 |
rs1217691063
|
|
Endothelial dysfunction
|
|
0.070 |
GeneticVariation
|
BEFREE |
Coexistence of homozygosity for the C677T mutation and B12 deficiency is associated with endothelial dysfunction and can be corrected with vitamin B12 and folic acid treatment.
|
17449548 |
2007 |
rs1217691063
|
|
Endothelial dysfunction
|
|
0.070 |
GeneticVariation
|
BEFREE |
C677T polymorphism in methylenetetrahydrofolate reductase gene (MTHFR) is a major determinant of hyperhomocysteinemia, which results in endothelial dysfunction.
|
15226090 |
2004 |
rs1217691063
|
|
Endothelial dysfunction
|
|
0.070 |
GeneticVariation
|
BEFREE |
A slight chronic hypoperfusion or an endothelial dysfunction associated with unfavorable genetic variations such as methylenetetrahydrofolate reductase C677T variation and angiotensin-converting enzyme I/D polymorphism then may lead indirectly to a malfunction of the molecular cross-talk between the nucleus and the mitochondria.
|
17114822 |
2007 |
rs1217691063
|
|
Endothelial dysfunction
|
|
0.070 |
GeneticVariation
|
BEFREE |
An increasing body of evidence suggests that different genetic factors, such as angiotensin-converting enzyme (ACE) I/D, angiotensin II type-1 receptor (AT1R) A1166C, methylenetetrahydrofolate reductase (MTHFR) C677T and ENOS G894T variants are associated with an endothelial dysfunction (ED).
|
17504188 |
2007 |
rs1799983
|
|
Endothelial dysfunction
|
|
0.090 |
GeneticVariation
|
BEFREE |
The 894T allele of a G894T polymorphism in the endothelial nitric oxide synthase (eNOS) gene is associated with decreased eNOS activity, cleavage of the protein, and endothelial dysfunction.
|
11668050 |
2001 |
rs1799983
|
|
Endothelial dysfunction
|
|
0.090 |
GeneticVariation
|
BEFREE |
The aim of this study was to test the hypothesis that inflammatory cytokines impairs endothelium-dependent relaxation and NO production gets vitiated due to eNOs Glu298Asp gene polymorphism causing endothelial dysfunction in eclampsia.
|
22958187 |
2013 |
rs1799983
|
|
Endothelial dysfunction
|
|
0.090 |
GeneticVariation
|
BEFREE |
The aim of this study was to test the hypothesis that (i) endothelial nitric oxide (NO) synthase Glu298Asp gene polymorphism limits constitutive NO production causing endothelial dysfunction and (ii) inflammatory cytokines impairs endothelium dependent relaxation in pre-eclampsia.
|
20047583 |
2010 |
rs1799983
|
|
Endothelial dysfunction
|
|
0.090 |
GeneticVariation
|
BEFREE |
In a population with a compromised endothelial function, concentrations of phenols in dietary VOO interact with NOS3 Glu298Asp to ameliorate the endothelial dysfunction associated to the TT genotype.
|
21816783 |
2011 |
rs1799983
|
|
Endothelial dysfunction
|
|
0.090 |
GeneticVariation
|
BEFREE |
Association of endothelial dysfunction with endothelin, nitric oxide and eNOS Glu298Asp gene polymorphism in coronary artery disease.
|
22045428 |
2011 |
rs1799983
|
|
Endothelial dysfunction
|
|
0.090 |
GeneticVariation
|
BEFREE |
Polymorphisms in the endothelial nitric oxide synthase ( eNOS ) gene (- 786T > C and 894G > T ) enhance endothelial dysfunction and have been studied in relation to coronary artery disease (CAD).
|
20846926 |
2010 |