|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Endothelial nitric oxide synthase (eNOS), which produces NO, plays an important role in the endothelial function under a wide range of physiological conditions. eNOS exon 7 polymorphism (Glu298Asp, G894T) has been considered to influence the risk of coronary artery disease.
|
15595935 |
2005 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this issue of Clinical Science, Agema and co-workers report the results of a genetic association study of eNOS (endothelial nitric oxide synthase) gene polymorphisms (-786T --> C, intron 4b --> a and Glu298 --> Asp) in patients with angiographic CAD (coronary artery disease), and/or prior MI (myocardial infarction) and a group of healthy population-based controls.
|
15283697 |
2004 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Glu298-->Asp polymorphism of the eNOS gene appears to be associated with the presence, extent, and severity of angiographically assessed coronary artery disease.
|
12010932 |
2002 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Relationship of the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and early-onset coronary artery disease.
|
11579346 |
2001 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Relationship between hemorheology and Glu(298)Asp polymorphism of endothelial nitric oxide synthase gene in patients with coronary artery disease.
|
19434512 |
2010 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of present study revealed that eNOS G894T polymorphism is associated with increased risk of CAD in our population.
|
21602253 |
2012 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We recently identified two endothelial nitric oxide synthase (eNOS) gene polymorphisms, Glu298Asp and T-786-->C, which are independently associated with coronary spasm. eNOS gene intron 4b/a polymorphism is also reported to be involved in smoking-dependent coronary artery disease.
|
10979242 |
2000 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present data extends earlier observations by the findings that predominantly younger T allele carriers of the ecNOS Glu(298)Asp gene polymorphism with various coronary high-risk profiles had an increased risk to suffer CAD and/or MI.
|
11755935 |
2002 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings show that the 27-bp VNTR polymorphic locus, but not the c.894G>T polymorphic locus, is associated with CAD and that it may regulate NOS3 pre-mRNA splicing in a length-dependent manner.
|
30447355 |
2019 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphism Glu298Asp of endothelial nitric oxide (eNOS) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial.
|
20083095 |
2010 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In Caucasians, association between E298D genotype and risk of coronary heart disease was significantly modified by current smoking status (interaction P=0.013), with the highest risk observed in smokers carrying the variant D298 allele relative to nonsmokers carrying two E298 alleles (adjusted hazard rate ratio 2.07, 95% confidence interval 1.39-3.07).
|
17108813 |
2006 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Lack of association of the Glu298Asp polymorphism of endothelial nitric oxide synthase with manifest coronary artery disease, carotid atherosclerosis and forearm vascular reactivity in two Austrian populations.
|
12641536 |
2003 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
NO level and endothelial NO synthase gene polymorphism (Glu298Asp) in the patients with coronary artery disease from the Turkish population.
|
15483745 |
2004 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease.
|
21816783 |
2011 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The G894T polymorphism of the eNOS gene is associated with the presence of CAD, and in conjunction with hyperhomocysteinemia, increased the risk of CAD severity in a Tunisian population.
|
16284093 |
2006 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, we also found that the rs1799983 polymorphism was significantly associated with the susceptibility to peripheral artery disease, whereas the rs2070744 polymorphism was significantly associated with the susceptibility to coronary artery disease in DM patients.
|
30140993 |
2018 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: a meta‑analysis of 39 case‑control studies.
|
23443250 |
2013 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggest that the G894T (rs1799983) polymorphism of the eNOS gene was associated with CAD in Tunisian patients.
|
25748584 |
2015 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, a common polymorphism in exon 7 of the eNOS gene (894G-->T) has been reported to be a strong risk factor for coronary artery disease.
|
9731617 |
1998 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine if the NOS3 genetic variants are associated with CAD in the Han Chinese, we examined the potential association between C</span>AD and eight single nucleotide polymorphisms (rs1799983, rs2070744, rs11771443, rs3918188, rs2853796, rs7830, rs1541861, and rs2853792) of the NOS3 using the MassARRAY system.
|
27323132 |
2016 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggest that the 894G>T, -786T>C and 4a/4b polymorphisms of the NOS3 were not associated with CAD in the studied subjects.
|
19931521 |
2010 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genotype frequencies for Glu298/Asp (Glu/Glu and Glu/Asp) genotypes were 75% and 25% in CAD subjects and 88% and 12% in control subjects, respectively.
|
22045428 |
2011 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The G894T polymorphism on endothelial nitric oxide synthase gene is associated with increased coronary heart disease among Asia population: evidence from a Meta analysis.
|
22417945 |
2012 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further subgroup analyses according to ethnicity of participants revealed that the rs1799983 and rs2070744 polymorphisms were significantly associated with the risk of coronary artery disease in both Caucasians and Asians, whereas the rs869109213 polymorphism was only associated with the risk of coronary artery disease in Caucasians.
|
30789045 |
2019 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of eNOS (-786T/C, Intron 4b/4a & 894G/T) and its association with asymptomatic first degree relatives of coronary heart disease patients.
|
27613099 |
2016 |