|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, there was evidence that small studies with more striking results could affect the associations of the Glu298Asp and -786T>C polymorphisms with coronary heart disease.
|
17018701 |
2006 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study was conducted to investigate the possible outcome of interaction between endothelial nitric oxide (NOS3) G894T and cholesteryl ester transfer TaqIB variants on the risk of coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM).
|
23157875 |
2012 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for Glu298Asp and M235T polymorphisms may predispose to CAD.
|
20547537 |
2011 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between the <i>NOS3</i> rs1799983 polymorphism and CAD may be partly mediated by abnormal NO and lipid levels caused by the T allele.
|
31138610 |
2019 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In contrast to previous reports, homozygosity for the Asp298 variant of the 894G>T polymorphism in the eNOS gene was not found to be associated with risk of AMI, extent of CAD and in-hospital mortality after AMI.
|
18495009 |
2008 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, a subgroup analysis adjusted with various cardiovascular risk factors confirmed positive association of the -786T>C polymorphism in CAD patients with hypertension and a smoking history and also a significant association of the intron 4 genotypes with a smoking history, but no significance has been found in the eNOS polymorphisms of 894G>T upon any risk adjustment.
|
16842840 |
2007 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Glu298Asp, T786-C and 27 bp VNTR b/a) with CAD.
|
25409023 |
2014 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (-786T>C, 4a4b, and 894G>T) have been previously associated with increased CAD risk.
|
26662450 |
2015 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
No significant associations were found between -1562 C/T (p = 0.557), Glu298Asp (p = 0.432), and -786 T/C (p = 0.055) polymorphisms and CAD.
|
19435423 |
2009 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of eNOS rs1799983 and ACE rs4646994 polymorphisms on the therapeutic efficacy of salvianolate injection in Chinese patients with coronary heart disease.
|
24827774 |
2014 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
On the basis of present results, it can be concluded that rs1799</span>983 is strongly associated with coronary artery disease in our population and TT genotype of this polymorphism enhanced the risk of coronary artery disease in Pakistani population.
|
25057159 |
2015 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggest that the G894T polymorphism of the eNOS gene was not associated with CAD in Chilean individuals.
|
16616056 |
2006 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study provides evidence that the Glu(298)-->Asp and T(786)-->C polymorphisms of the eNOS gene are associated with the presence and severity of angiographically defined CAD in the Italian population and that those individuals carrying both eNOS variants simultaneously might have a higher risk of developing CAD.
|
12600950 |
2003 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, although Glu298Asp did not show association with CAD and lipid profile in the studied cohort, it may exert its effect through blood pressure; however, the mechanism of this effect needs to be explored in the future.
|
28620990 |
2017 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The synthesis of available evidence supports the fact that eNOS G894T andT-786C are associated with CAD.
|
20861627 |
2010 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study, for the first time, suggests an independent association of 894G>T and -786T>C polymorphisms of endothelial nitric oxide synthase gene with coronary artery disease in a Saudi population.
|
20470943 |
2010 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interactive effects of the ACE DD polymorphism with the NOS III homozygous G849T (Glu298-->Asp) variant in determining endothelial function in coronary artery disease.
|
14989558 |
2003 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, we confirmed that the eNOS G894T polymorphism is a risk factor for premature CAD, particularly in those suffering premature MI.
|
29100441 |
2017 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the eNOS Glu-298-->Asp mutation is common, occurring with an allele frequency of 32.5%, but is not associated with either the occurrence or severity of CAD in the Australian population or with other established coronary risk factors assessed in our study.
|
10475066 |
1999 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A missense mutation of the nitric oxide synthase (eNOS) gene (Glu298Asp) in five patients with coronary artery disease--case reports.
|
10451235 |
1999 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for a common NOS 3 polymorphism (894 G-->T) which encodes a Glu298-->Asp amino acid substitution in eNOS is a risk factor for angiographic CAD and recent MI in this population.
|
10510054 |
1999 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms in the endothelial nitric oxide synthase ( eNOS ) gene (- 786T > C and 894G > T ) enhance endothelial dysfunction and have been studied in relation to coronary artery disease (CAD).
|
20846926 |
2010 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
AF patients with rs1799983 variants were more likely to have coronary artery disease or stroke than those without genetic variant at this gene (31.0% vs. 17.3%, p=0.004).
|
26256966 |
2015 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the effects of a variable nucleotide tandem repeats (VNTR) in intron 4, G894T in exon 7 and T-786C at the promoter region of NOS3 on i) C-reactive protein (CRP) and macrophage-colony stimulating-factor (MCSF), and ii) augmentation index (AI) measured by pulse-wave analysis , flow-mediated dilation (FMD) of the brachial artery, intima-media thickness (IMT) of the carotid and femoral artery using ultrasonography and ankle-brachial index (ABI) in 122 patients with chronic coronary artery disease (CAD) who underwent coronary angiography.
|
17003932 |
2006 |
|
rs1799983
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We performed multiple logistic regression analysis for the effect of the T(-786)C, the missense Glu298Asp variant, and other coronary risk factors on two- and three-vessel CAD.
|
12651036 |
2003 |