rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The pattern of low BDNF and high inflammation in MDD may be influenced by the Val66Met polymorphism.
|
28656803 |
2018 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study looked at a population of patients with major depressive disorder (N = 107) to examine the association between the BDNF Val66Met polymorphism, resting state EEG alpha power, and depression severity.
|
23733090 |
2013 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the relationship between a brain-derived neurotrophic factor (BDNF) polymorphism (Val66Met) and the clinical response of patients with major depressive disorder to selective serotonin reuptake inhibitors (SSRIs; here, paroxetine and sertraline).
|
21338649 |
2011 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain derived neurotrophic factor gene polymorphism (Val66Met) and short-term antidepressant response in major depressive disorder.
|
20674983 |
2010 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Haplotype analysis of marker combination rs988748-(GT)n-rs6265 produced nominally significant associations for all investigated phenotypes (global p values: MDD p = .00006, BPAD p = .0057, schizophrenia p = .016).
|
16005437 |
2005 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
This is a systematic meta-analytical review of findings from imaging genetic studies on the impact of the rs6265 SNP on hippocampal volumes in neuropsychiatric patients with major depressive disorder, anxiety, bipolar disorder or schizophrenia.
|
25956254 |
2015 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further gene-gene interaction analyses showed a significant effect of a two-locus BDNF/GSK3B interaction with MDD (GSK3B rs6782799 and BDNF rs7124442) (corrected P = 0.011), and also for a three-locus interaction (GSK3B rs6782799, BDNF rs6265 and BDNF rs7124442) (corrected P = 0.019).
|
20033742 |
2010 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent meta-analyses point towards a pathogenic role of the Val66Met variant of the brain-derived neurotrophic factor (BDNF) in major depressive disorder, specifically in males.
|
22033217 |
2012 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Taken together, we did not detect any plausible evidence regarding Val66Met polymorphism in the BDNF gene contributing to a risk of MDD.
|
29387021 |
2017 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain-derived neurotrophic factor (BDNF) polymorphisms G196A and C270T are not associated with response to electroconvulsive therapy in major depressive disorder.
|
17036259 |
2007 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder.
|
16979146 |
2006 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder.
|
25745134 |
2015 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our study was to evaluate the association of regional gray matter (GM) volume within the hippocampus and other unpredicted regions at the whole-brain level with the BDNF Val66Met polymorphism in MDD patients with melancholic features and their impact on treatment outcome.
|
23165919 |
2013 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants.
|
17401528 |
2007 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF polymorphism was associated with atrophy of the PFC in MDD patients, which suggests that the BDNF Val66Met polymorphism may play an important role in the pathogenesis of early stages of MDD.
|
26078197 |
2015 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The relationship was investigated between brain-derived neurotrophic factor (BDNF) concentrations, a <i>BDNF</i> polymorphism (196G>A), and the response to selective serotonin reuptake inhibitors (SSRIs) among Chinese patients with major depressive disorder (MDD).
|
31308724 |
2019 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study aimed to clarify whether, in the presence of previous childhood maltreatment, individuals carrying low functional alleles for both SERT 5-HTTLPR and BDNF Val66Met polymorphisms had a higher risk for MD.
|
25510949 |
2015 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results indicate that there was a lack of association between severity of depression and BDNF Val66Met polymorphism in Chinese patients with MDD.
|
20016225 |
2010 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the current study, we examined BDNF polymorphisms (G-712A, C270T and Val66Met) in 202 patients with MD and 323 patients with schizophrenia.
|
21129438 |
2011 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Three polymorphisms in the BDNF gene (rs7103411, rs6265 (Val66Met) and rs7124442) were genotyped in 324 patients with MDD and 470 healthy controls.
|
22965830 |
2013 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Common genetic variants, such as the brain-derived neurotrophic factor (BDNF) Val/66/Met polymorphism (rs6265), are known to interact with environmental factors such as early adversity to increase the risk of subsequent major depression.
|
22844024 |
2012 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine the effect of BDNF gene val66met polymorphism on serum BDNF levels in drug-free patients with major depressive disorder (MDD) and healthy subjects, that differ by gender.
|
19589373 |
2010 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
CRHR1 gene (rs1876828, rs242939 and rs242941) and BDNF gene (rs6265) were identified in the samples of patients diagnosed with recurrent MDD and matched controls.
|
22194899 |
2011 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among the various candidate genes implicated in MDD, the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and 5-HT transporter gene linked polymorphism (5-HTTLPR) have garnered the most attention due to their putative roles in neural plasticity and antidepressant response.
|
26976307 |
2016 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
To conclude, we did not replicate the Val66Met effect on hippocampal volume in neither patients with major depression nor in healthy participants.
|
19668114 |
2009 |