rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study tested the hypothesis that the BDNF-gene Val66Met polymorphism is associated with MDD, its clinical manifestations, and antidepressant response.
|
14582140 |
2003 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Haplotype analysis of marker combination rs988748-(GT)n-rs6265 produced nominally significant associations for all investigated phenotypes (global p values: MDD p = .00006, BPAD p = .0057, schizophrenia p = .016).
|
16005437 |
2005 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder.
|
16979146 |
2006 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We genotyped the BDNF-gene Val66Met polymorphism in 110 elderly inpatients diagnosed with major depression and 171 age- and sex-similar control subjects.
|
16343697 |
2006 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain-derived neurotrophic factor (BDNF) polymorphisms G196A and C270T are not associated with response to electroconvulsive therapy in major depressive disorder.
|
17036259 |
2007 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants.
|
17401528 |
2007 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings support the association of BDNF single nucleotide polymorphism rs6265 and depression, suggesting that this polymorphism may increase susceptibility to major depression in Mexican-Americans.
|
17632285 |
2007 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the BDNF Val66Met polymorphism is not related to the development of MDD but related to clinical features of MDD in a Japanese population.
|
17510948 |
2007 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine the effect of the BDNF Val66Met polymorphism on hippocampal and amygdala volumes in patients with major depression and in healthy control subjects.
|
17404118 |
2007 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
A functional polymorphism of the brain-derived neurotrophic factor, BDNF Val66Met, is associated with risk for major depression alongside impairments in memory and selective attention.
|
18721847 |
2008 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
To conclude, we did not replicate the Val66Met effect on hippocampal volume in neither patients with major depression nor in healthy participants.
|
19668114 |
2009 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that SNPs rs6265, rs10835210 and rs2030324 of the BDNF gene are unlikely to play a critical role in the pathogenesis of MDD.
|
19699537 |
2009 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain derived neurotrophic factor gene polymorphism (Val66Met) and short-term antidepressant response in major depressive disorder.
|
20674983 |
2010 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further gene-gene interaction analyses showed a significant effect of a two-locus BDNF/GSK3B interaction with MDD (GSK3B rs6782799 and BDNF rs7124442) (corrected P = 0.011), and also for a three-locus interaction (GSK3B rs6782799, BDNF rs6265 and BDNF rs7124442) (corrected P = 0.019).
|
20033742 |
2010 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results indicate that there was a lack of association between severity of depression and BDNF Val66Met polymorphism in Chinese patients with MDD.
|
20016225 |
2010 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine the effect of BDNF gene val66met polymorphism on serum BDNF levels in drug-free patients with major depressive disorder (MDD) and healthy subjects, that differ by gender.
|
19589373 |
2010 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis of BDNF Val66Met polymorphism association with treatment response in patients with major depressive disorder.
|
20167454 |
2010 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the BDNF Val66Met polymorphism is of greater importance in the development of MDD in men than in women.
|
18852698 |
2010 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results do not support the hypothesis that the Val66Met promoter polymorphism in the BDNF gene influences the therapeutic response to mirtazapine in Korean MDD patients.
|
19493959 |
2010 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Under a dominant model, we observed a potential association between the GSK3B rs6782799 and MDD (P=0.07), a significant three-way interaction among BDNF rs6265, GSK3B rs6782799, and negative life events (corrected P-value, 0.011-0.012; cross-validation consistency, 7; prediction error, 0.4349).
|
20682308 |
2010 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the relationship between a brain-derived neurotrophic factor (BDNF) polymorphism (Val66Met) and the clinical response of patients with major depressive disorder to selective serotonin reuptake inhibitors (SSRIs; here, paroxetine and sertraline).
|
21338649 |
2011 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the current study, we examined BDNF polymorphisms (G-712A, C270T and Val66Met) in 202 patients with MD and 323 patients with schizophrenia.
|
21129438 |
2011 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
CRHR1 gene (rs1876828, rs242939 and rs242941) and BDNF gene (rs6265) were identified in the samples of patients diagnosed with recurrent MDD and matched controls.
|
22194899 |
2011 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although not observed in younger adult cohorts, in older individuals the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with major depressive disorder (MDD) risk.
|
20195291 |
2011 |
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
None of the eight SNPs, including the rs6265, were significantly associated with MDD after permutation correction.
|
21188787 |
2011 |