|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study tested the hypothesis that the BDNF-gene Val66Met polymorphism is associated with MDD, its clinical manifestations, and antidepressant response.
|
14582140 |
2003 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Haplotype analysis of marker combination rs988748-(GT)n-rs6265 produced nominally significant associations for all investigated phenotypes (global p values: MDD p = .00006, BPAD p = .0057, schizophrenia p = .016).
|
16005437 |
2005 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder.
|
16979146 |
2006 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We genotyped the BDNF-gene Val66Met polymorphism in 110 elderly inpatients diagnosed with major depression and 171 age- and sex-similar control subjects.
|
16343697 |
2006 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the BDNF Val66Met polymorphism is not related to the development of MDD but related to clinical features of MDD in a Japanese population.
|
17510948 |
2007 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings support the association of BDNF single nucleotide polymorphism rs6265 and depression, suggesting that this polymorphism may increase susceptibility to major depression in Mexican-Americans.
|
17632285 |
2007 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine the effect of the BDNF Val66Met polymorphism on hippocampal and amygdala volumes in patients with major depression and in healthy control subjects.
|
17404118 |
2007 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain-derived neurotrophic factor (BDNF) polymorphisms G196A and C270T are not associated with response to electroconvulsive therapy in major depressive disorder.
|
17036259 |
2007 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants.
|
17401528 |
2007 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
A functional polymorphism of the brain-derived neurotrophic factor, BDNF Val66Met, is associated with risk for major depression alongside impairments in memory and selective attention.
|
18721847 |
2008 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
To conclude, we did not replicate the Val66Met effect on hippocampal volume in neither patients with major depression nor in healthy participants.
|
19668114 |
2009 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that SNPs rs6265, rs10835210 and rs2030324 of the BDNF gene are unlikely to play a critical role in the pathogenesis of MDD.
|
19699537 |
2009 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the BDNF Val66Met polymorphism is of greater importance in the development of MDD in men than in women.
|
18852698 |
2010 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain derived neurotrophic factor gene polymorphism (Val66Met) and short-term antidepressant response in major depressive disorder.
|
20674983 |
2010 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results do not support the hypothesis that the Val66Met promoter polymorphism in the BDNF gene influences the therapeutic response to mirtazapine in Korean MDD patients.
|
19493959 |
2010 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Under a dominant model, we observed a potential association between the GSK3B rs6782799 and MDD (P=0.07), a significant three-way interaction among BDNF rs6265, GSK3B rs6782799, and negative life events (corrected P-value, 0.011-0.012; cross-validation consistency, 7; prediction error, 0.4349).
|
20682308 |
2010 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results indicate that there was a lack of association between severity of depression and BDNF Val66Met polymorphism in Chinese patients with MDD.
|
20016225 |
2010 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine the effect of BDNF gene val66met polymorphism on serum BDNF levels in drug-free patients with major depressive disorder (MDD) and healthy subjects, that differ by gender.
|
19589373 |
2010 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further gene-gene interaction analyses showed a significant effect of a two-locus BDNF/GSK3B interaction with MDD (GSK3B rs6782799 and BDNF rs7124442) (corrected P = 0.011), and also for a three-locus interaction (GSK3B rs6782799, BDNF rs6265 and BDNF rs7124442) (corrected P = 0.019).
|
20033742 |
2010 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis of BDNF Val66Met polymorphism association with treatment response in patients with major depressive disorder.
|
20167454 |
2010 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the current study, we examined BDNF polymorphisms (G-712A, C270T and Val66Met) in 202 patients with MD and 323 patients with schizophrenia.
|
21129438 |
2011 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated cross-sectionally in 1,435 individuals with lifetime MDD the impact of childhood abuse (CA) and recent life events on serum BDNF levels and assessed whether the impact of these events was moderated by the BDNF Val(66)Met polymorphism.
|
20703451 |
2011 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although not observed in younger adult cohorts, in older individuals the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with major depressive disorder (MDD) risk.
|
20195291 |
2011 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, there was no significant difference in normalized HCV between 5HTTLPR diallelic and triallelic classifications or between the BDNF Val66Met</span> genotypes in MDD patients, although there was a relationship between BDNF Val66Met and ICV.
|
21692988 |
2011 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF val66met polymorphism may play a salient role in structural alterations of the hippocampus in older adults with MDD.
|
21218562 |
2011 |