|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
CRHR1 gene (rs1876828, rs242939 and rs242941) and BDNF gene (rs6265) were identified in the samples of patients diagnosed with recurrent MDD and matched controls.
|
22194899 |
2011 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
None of the eight SNPs, including the rs6265, were significantly associated with MDD after permutation correction.
|
21188787 |
2011 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the relationship between a brain-derived neurotrophic factor (BDNF) polymorphism (Val66Met) and the clinical response of patients with major depressive disorder to selective serotonin reuptake inhibitors (SSRIs; here, paroxetine and sertraline).
|
21338649 |
2011 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Serum BDNF levels, but not plasma levels of HVA or MHPG, and BDNF Val66Met polymorphism are related to the mirtazapine response in MDD.
|
22883353 |
2012 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Common genetic variants, such as the brain-derived neurotrophic factor (BDNF) Val/66/Met polymorphism (rs6265), are known to interact with environmental factors such as early adversity to increase the risk of subsequent major depression.
|
22844024 |
2012 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype.
|
22585743 |
2012 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent meta-analyses point towards a pathogenic role of the Val66Met variant of the brain-derived neurotrophic factor (BDNF) in major depressive disorder, specifically in males.
|
22033217 |
2012 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found no significant association of either the BDNF G196A or MTHFR C677T polymorphisms with major depressive disorder neither in female nor male group of patients.
|
23255668 |
2012 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study looked at a population of patients with major depressive disorder (N = 107) to examine the association between the BDNF Val66Met polymorphism, resting state EEG alpha power, and depression severity.
|
23733090 |
2013 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our study was to evaluate the association of regional gray matter (GM) volume within the hippocampus and other unpredicted regions at the whole-brain level with the BDNF Val66Met polymorphism in MDD patients with melancholic features and their impact on treatment outcome.
|
23165919 |
2013 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine whether the polymorphisms of BDNF (rs6265) and NTRK2 (rs1387923, rs2769605 and rs1565445) genes confer risk for TRD in major depressive disorder (MDD), a total of 948 MDD patients were recruited in a 12-week, multicenter, prospective longitudinal study.
|
23137999 |
2013 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of MDD with genetic polymorphisms, such as Val66Met (rs6265), in the brain derived neurotrophic factor (BDNF), have been reported in many studies and the results were conflicting.
|
23184535 |
2013 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Three polymorphisms in the BDNF gene (rs7103411, rs6265 (Val66Met) and rs7124442) were genotyped in 324 patients with MDD and 470 healthy controls.
|
22965830 |
2013 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant associations between AD and MDD have been found for three polymorphisms mainly in females (TPH1 A218C, MAOA VNTR and BDNF Val66Met) and one polymorphism in the total population only (FKBP5 rs1360780).
|
23157339 |
2013 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our two-center study was to determine how the BDNF Val66Met</span> polymorphism and childhood adversity affect the volumetric measures of the hippocampus in healthy individuals and people with MDD.
|
23341118 |
2013 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine which hippocampal dentate gyrus and cornu ammonis subfields are altered in MDD compared to healthy controls and which subfields are affected by the BDNF Val</span>66Met</span> polymorphism and child adversity.
|
25044977 |
2014 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF polymorphism was associated with atrophy of the PFC in MDD patients, which suggests that the BDNF Val66Met polymorphism may play an important role in the pathogenesis of early stages of MDD.
|
26078197 |
2015 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
This is a systematic meta-analytical review of findings from imaging genetic studies on the impact of the rs6265 SNP on hippocampal volumes in neuropsychiatric patients with major depressive disorder, anxiety, bipolar disorder or schizophrenia.
|
25956254 |
2015 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder.
|
25745134 |
2015 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study aimed to clarify whether, in the presence of previous childhood maltreatment, individuals carrying low functional alleles for both SERT 5-HTTLPR and BDNF Val66Met polymorphisms had a higher risk for MD.
|
25510949 |
2015 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that allelic variations in the rs6265 gene lead to specific neural correlates of MDD which may be associated with different mechanisms of MDD in the two allelic groups.
|
26117067 |
2015 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The gene-environment combination of PRKCG rs3745406 C allele, BDNF rs6265 G allele and high level of negative life events (C-G-HN) was significantly associated with MDD (OR, 5.97; 95% CI, 2.71-13.15).
|
26921055 |
2016 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggested that 5-HTTLPR, may be associated with the susceptibility of MDD in an overdominant mode, and there may be a significant interaction between 5-HTTLPR and BDNF (rs6265) polymorphisms in relation to MDD.
|
27212180 |
2016 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among the various candidate genes implicated in MDD, the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and 5-HT transporter gene linked polymorphism (5-HTTLPR) have garnered the most attention due to their putative roles in neural plasticity and antidepressant response.
|
26976307 |
2016 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant interactions between the Val66Met polymorphism and 3 clinical characteristics - age at onset (p = 0.03), MDD duration (p = 0.04), and number of previous MDE (p = 0.04) - were evidenced for plasma BDNF levels.
|
28848102 |
2017 |