|
rs1800469
|
|
Chronic Obstructive Airway Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Among smokers in the COPD cases and control subjects, two SNPs in the promoter region of TGFB1 (rs2241712 and rs1800469) and one SNP in exon 1 of TGFB1 (rs1982073) were significantly associated with COPD (P</=0.02 in all cases).
|
15175276 |
2004 |
|
rs1800469
|
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated whether the -509C/T (rs1800469), 868T/C (rs1982073), 913G/C (rs1800471), and 11929C/T (rs1800472) polymorphisms of TGFB1 are associated with myocardial infarction.
|
16543493 |
2006 |
|
rs1800469
|
|
Cystic Fibrosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We used a family-based approach to test for association between lung function and two functional SNPs (rs1800469, '-509' and rs1982073, 'codon 10') in the 5' region of transforming growth factor-beta1 (TGFB1), a putative CF modifier gene.
|
18424453 |
2008 |
|
rs1800469
|
|
Gallbladder Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of our present study was to determine the association of EGF+61A>G (rs4444903) and TGFB1-509C>T (rs1800469) gene polymorphism with susceptibility to gallbladder cancer (GBC).
|
18571008 |
2008 |
|
rs1800469
|
|
Stage IV Gallbladder Cancer AJCC v8
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of our present study was to determine the association of EGF+61A>G (rs4444903) and TGFB1-509C>T (rs1800469) gene polymorphism with susceptibility to gallbladder cancer (GBC).
|
18571008 |
2008 |
|
rs1800469
|
|
Malignant neoplasm of gallbladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of our present study was to determine the association of EGF+61A>G (rs4444903) and TGFB1-509C>T (rs1800469) gene polymorphism with susceptibility to gallbladder cancer (GBC).
|
18571008 |
2008 |
|
rs1800469
|
|
Stage IIB Gallbladder Cancer AJCC v8
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of our present study was to determine the association of EGF+61A>G (rs4444903) and TGFB1-509C>T (rs1800469) gene polymorphism with susceptibility to gallbladder cancer (GBC).
|
18571008 |
2008 |
|
rs1800469
|
|
Stage IIA Gallbladder Cancer AJCC v8
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of our present study was to determine the association of EGF+61A>G (rs4444903) and TGFB1-509C>T (rs1800469) gene polymorphism with susceptibility to gallbladder cancer (GBC).
|
18571008 |
2008 |
|
rs1800469
|
|
Stage III Gallbladder Cancer AJCC v8
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of our present study was to determine the association of EGF+61A>G (rs4444903) and TGFB1-509C>T (rs1800469) gene polymorphism with susceptibility to gallbladder cancer (GBC).
|
18571008 |
2008 |
|
rs1800469
|
|
Stage 0 Gallbladder Cancer AJCC v8
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of our present study was to determine the association of EGF+61A>G (rs4444903) and TGFB1-509C>T (rs1800469) gene polymorphism with susceptibility to gallbladder cancer (GBC).
|
18571008 |
2008 |
|
rs1800469
|
|
Urologic Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Previous reports have shown that the TT genotype of the rs1800469 polymorphism is a risk factor for renal scarring in primary VUR, and the results of our study suggest that this same polymorphism is associated with susceptibility to this congenital uropathy.
|
18685869 |
2008 |
|
rs1800469
|
|
Vesico-Ureteral Reflux
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to assess the association between the transforming growth factor-beta1 (TGF-beta1) gene polymorphisms rs1800469 (commonly known as T-509C) and rs1982073 (commonly known as Leu (10)-->Pro) and primary vesicoureteral reflux (VUR) and renal scarring.
|
18685869 |
2008 |
|
rs1800469
|
|
Vesicoureteral Reflux 1
|
|
0.010 |
GeneticVariation
|
BEFREE |
Previous reports have shown that the TT genotype of the rs1800469 polymorphism is a risk factor for renal scarring in primary VUR, and the results of our study suggest that this same polymorphism is associated with susceptibility to this congenital uropathy.
|
18685869 |
2008 |
|
rs1800469
|
|
Common Migraine
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.
|
19559392 |
2009 |
|
rs1800469
|
|
Migraine Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
Regarding any history of migraine, the multivariable-adjusted odds ratios (95% confidence intervals) for TNF rs673 were 0.52 (0.30 to 0.89), for TGFB1 rs1800469 0.93 (0.89 to 0.98), and for CCR2 rs1799864 1.12 (1.03 to 1.21).
|
19559392 |
2009 |
|
rs1800469
|
|
Malignant tumor of colon
|
|
0.710 |
GeneticVariation
|
BEFREE |
Both TGFβ1 rs1800469 and rs4803455 were associated with colon cancer [odds ratio (OR) = 0.65 and 1.43, 95% CI = 0.51-0.84 and 1.18-1.73, respectively) but not rectal cancer.
|
21068203 |
2011 |
|
rs1800469
|
|
Rectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Both TGFβ1 rs1800469 and rs4803455 were associated with colon cancer [odds ratio (OR) = 0.65 and 1.43, 95% CI = 0.51-0.84 and 1.18-1.73, respectively) but not rectal cancer.
|
21068203 |
2011 |
|
rs1800469
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Both TGFβ1 rs1800469 and rs4803455 were associated with colon cancer [odds ratio (OR) = 0.65 and 1.43, 95% CI = 0.51-0.84 and 1.18-1.73, respectively) but not rectal cancer.
|
21068203 |
2011 |
|
rs1800469
|
|
Chronic Obstructive Airway Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
The results showed that there was no significant association between an increased risk of COPD in carriers of the T allele (TT+TC) versus the CC genotype in rs1800469 and rs1982073.
|
21556788 |
2011 |
|
rs1800469
|
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we confirmed the association of rs1800469 in TGF-beta1 and rs20541 in IL-13 with asthma and found a trend toward association between rs2241712 in TGF-beta1 and rs2070874 in IL-4 with asthma among atopic subjects, suggesting TGF-beta1, IL-4 and IL-13 may be associated with the susceptibility and development of asthma in this Chinese population.
|
22053598 |
2011 |
|
rs1800469
|
|
Hepatitis A
|
|
0.010 |
GeneticVariation
|
BEFREE |
In contrast, among Mexican Americans, variants in two genes were found to be associated with an increased risk of HAV infection: TGFB1 rs1800469 (adjusted odds ratio [OR], 1.38; 95% confidence interval [CI], 1.14-1.68; P value adjusted for false discovery rate [FDR-P] = 0.017) and XRCC1 rs1799782 (OR, 1.57; 95% CI, 1.27-1.94; FDR-P = 0.0007).
|
22135187 |
2012 |
|
rs1800469
|
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
PCR-based assays were used to determine the genotypes of TGFB1 SNPs including TGFB1-509 C/T (rs1800469, in the promoter region), +868 T/C (rs1800470, in exon 1) and +913 G/C (rs1800471, in exon 1) in 414 subjects with established RA.
|
22513132 |
2012 |
|
rs1800469
|
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Minor allele carriers of two genetic variants (rs1800469 and rs1982073) in TGFB1 have a 15% increased risk of CHD.
|
22607024 |
2012 |
|
rs1800469
|
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Applying a dominant model of inheritance, three TGF-β1 SNPs were significantly associated with CHD complications: The T alleles of rs1800469 (OR = 1.125, 95% CI 1.016-1.247, p = 0.031) and rs1800470 (OR = 1.146, 95% CI 1.026-1.279, p = 0.021); and the C allele of rs1800471 (OR = 1.207, 95% CI 1.037-1.406, p = 0.021).
|
22662243 |
2012 |
|
rs1800469
|
|
Chronic Obstructive Airway Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
The SNP rs1800469 is reported to be associated with chronic obstructive pulmonary disease and lung cancer in cigarette smokers.
|
23094028 |
2012 |