|
rs1800469
|
|
Colorectal Carcinoma
|
|
0.810 |
GeneticVariation
|
BEFREE |
In this context, the aim of the study was to explore the role of circulating TGF-β1 and the -509C/T functional promoter polymorphism (rs1800469) within the TGF-β1 gene (TGFB1) in the susceptibility, progression, and prognosis of CRC among Bulgarian male and female patients.
|
30071009 |
2018 |
|
rs1800469
|
|
Malignant tumor of colon
|
|
0.710 |
GeneticVariation
|
BEFREE |
Both TGFβ1 rs1800469 and rs4803455 were associated with colon cancer [odds ratio (OR) = 0.65 and 1.43, 95% CI = 0.51-0.84 and 1.18-1.73, respectively) but not rectal cancer.
|
21068203 |
2011 |
|
rs1800469
|
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
Four-locus (rs1800472-rs1800471-rs1800470-rs1800469) Haploview analysis identified haplotype <u>T</u>G<u>CT</u> to be negatively associated, and haplotypes CGT<u>T</u> and C<u>CC</u>C to be positively associated with BC.
|
31405342 |
2019 |
|
rs1800469
|
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Four-locus (rs1800472-rs1800471-rs1800470-rs1800469) Haploview analysis identified haplotype <u>T</u>G<u>CT</u> to be negatively associated, and haplotypes CGT<u>T</u> and C<u>CC</u>C to be positively associated with BC.
|
31405342 |
2019 |
|
rs1800469
|
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The present study investigated the effects of the TGFB1 promoter region (rs1800468 or G-800A and rs1800469 or C-509T) and signal peptide (rs1800470 or C29T and rs1800471 or G74C) single nucleotide polymorphisms (SNPs) and their haplotype structures on the susceptibility and clinicopathological presentation of BC subtypes.
|
29362917 |
2018 |
|
rs1800469
|
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
The present study investigated the effects of the TGFB1 promoter region (rs1800468 or G-800A and rs1800469 or C-509T) and signal peptide (rs1800470 or C29T and rs1800471 or G74C) single nucleotide polymorphisms (SNPs) and their haplotype structures on the susceptibility and clinicopathological presentation of BC subtypes.
|
29362917 |
2018 |
|
rs1800469
|
|
Chronic Obstructive Airway Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
No associations with COPD were identified for other polymorphisms evaluated in the present study including rs1800469 (T allele compared with C allele, OR =0.89, 95% CI: 0.77-1.02, <i>P</i>=0.099), rs2241712 (A allele compared with G allele, OR =1.03, 95% CI: 0.89-1.20, <i>P</i>=0.666), rs6957 (A allele compared with G allele, OR =1.14, 95% CI: 0.95-1.36, <i>P</i>=0.160), and rs2241718 (C allele compared with T allele, OR =0.95, 95% CI: 0.79-1.14, <i>P</i>=0.571).
|
28784933 |
2017 |
|
rs1800469
|
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Multivariate logistic regression found SNPs in genes important for T helper type 1 (Th1) immunity (IFNGR2 rs1059293, IL15RA rs2296135, LTA rs1041981), Th2 immunity (IL4R rs1801275), and T regulatory cell-mediated immunosuppression (TGFB1 rs1800469) associated with breast cancer risk, mainly among AAs.
|
23996684 |
2014 |
|
rs1800469
|
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
Multivariate logistic regression found SNPs in genes important for T helper type 1 (Th1) immunity (IFNGR2 rs1059293, IL15RA rs2296135, LTA rs1041981), Th2 immunity (IL4R rs1801275), and T regulatory cell-mediated immunosuppression (TGFB1 rs1800469) associated with breast cancer risk, mainly among AAs.
|
23996684 |
2014 |
|
rs1800469
|
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
This meta-analysis has not confirmed previous reports of association between fibrosis or overall toxicity and rs1800469 genotype in breast cancer patients.
|
23199655 |
2012 |
|
rs1800469
|
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
This meta-analysis has not confirmed previous reports of association between fibrosis or overall toxicity and rs1800469 genotype in breast cancer patients.
|
23199655 |
2012 |
|
rs1800469
|
|
Chronic Obstructive Airway Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
The SNP rs1800469 is reported to be associated with chronic obstructive pulmonary disease and lung cancer in cigarette smokers.
|
23094028 |
2012 |
|
rs1800469
|
|
Chronic Obstructive Airway Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
The results showed that there was no significant association between an increased risk of COPD in carriers of the T allele (TT+TC) versus the CC genotype in rs1800469 and rs1982073.
|
21556788 |
2011 |
|
rs1800469
|
|
Chronic Obstructive Airway Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Among smokers in the COPD cases and control subjects, two SNPs in the promoter region of TGFB1 (rs2241712 and rs1800469) and one SNP in exon 1 of TGFB1 (rs1982073) were significantly associated with COPD (P</=0.02 in all cases).
|
15175276 |
2004 |
|
rs1800469
|
|
Primary malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
The TGF-β1 T + 869C (rs1982073) and C-509T (rs1800469</span>) polymorphisms are not implicated in lung cancer susceptibility in the overall population.
|
31764821 |
2019 |
|
rs1800469
|
|
Malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
The TGF-β1 T + 869C (rs1982073) and C-509T (rs1800469</span>) polymorphisms are not implicated in lung cancer susceptibility in the overall population.
|
31764821 |
2019 |
|
rs1800469
|
|
Non-Small Cell Lung Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, our analysis indicated that the C-509T (rs1800469) polymorphism decreases the risk of lung cancer in patients with NSCLC.
|
31764821 |
2019 |
|
rs1800469
|
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
The TGF-β1 T + 869C (rs1982073) and C-509T (rs1800469</span>) polymorphisms are not implicated in lung cancer susceptibility in the overall population.
|
31764821 |
2019 |
|
rs1800469
|
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
In the subset analysis by the type of MI, significantly elevated risk of MI</span> was associated with the homozygote TT and heterozygote C/T in no-AMI subjects, when compared with the CC homozygote carriers (OR = 1.12, 95% CI:1.02-1.23).Our meta-analysis shows that the polymorphism with homozygote TT and heterozygote C/T of TGF-β 509C/T (rs1800469) is significantly associated with the increased risk of MI.
|
31261499 |
2019 |
|
rs1800469
|
|
Hepatitis C
|
|
0.020 |
GeneticVariation
|
BEFREE |
Here, this paper proposed a meta-analysis to evaluate whether the TGF-ß1 gene polymorphisms, -509C/T (rs1800469), codon 10 T/C (rs1982073) and codon 25G/C (rs1800471), were associated with chronic HCV infection.
|
31470810 |
2019 |
|
rs1800469
|
|
Hepatitis C
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, rs1800469 in TGFB1 was associated to hepatic decompensation in chronic hepatitis C, while the other 11 described polymorphisms must be evaluated in a larger cohort to determine the possible role of vitamin D in hepatitis C.
|
28703134 |
2017 |
|
rs1800469
|
|
Non-Small Cell Lung Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that the TGFB1 rs1800469 polymorphism may be predictive biomarker for the risk of developing brain metastasis in non-small cell lung cancer patients.
|
25966122 |
2015 |
|
rs1800469
|
|
Atrial Fibrillation
|
|
0.020 |
GeneticVariation
|
BEFREE |
Herein, the TGF-β1 C-509 T polymorphism (rs1800469) was genotyped in a case-control study of 840 patients and 845 controls in Chinese population to explore the association between the polymorphism and susceptibility and prognosis of lone AF.
|
25402477 |
2014 |
|
rs1800469
|
|
Atrial Fibrillation
|
|
0.020 |
GeneticVariation
|
BEFREE |
After adjustment for age, sex, hypertension and LAD, there was no association between the rs1800469 polymorphism and the risk of AF under the dominant, recessive and additive genetic models.
|
24349426 |
2013 |
|
rs1800469
|
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Minor allele carriers of two genetic variants (rs1800469 and rs1982073) in TGFB1 have a 15% increased risk of CHD.
|
22607024 |
2012 |