rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The AMD cases possessing the LOC387715 (rs10490924) variant may have a higher risk of neovascular AMD.
|
17210853 |
2007 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Two SNPs generated highly significant allelic associations with PCV (rs10490924, P = 5.7 x 10(-6); rs11200638, P = 5.2 x 10(-6)) and AMD (rs10490924, P = 1.4 x 10(-6); rs11200638, P = 3.4 x 10(-7)).
|
17692272 |
2007 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We propose that rs10490924 represents a major susceptibility variant for AMD at 10q26.
|
17884985 |
2007 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
To examine phenotypes of age-related macular degeneration (AMD) patients with the LOC387715 variant (T allele at rs10490924, A69S).
|
18061132 |
2008 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Many single-nucleotide polymorphisms (SNPs), including the previously reported variants rs10</span>490924 (hypothetical LOC387715/ARMS2) and rs11200638 (HTRA1), defined 2 significant haplotypes associated with increased risk of neovascular AMD.
|
18164066 |
2008 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Using DNA extracted from venous blood of 876 white participants in AREDS categories 3 and 4, that is, those considered to be at high risk for progression to advanced AMD, the authors genotyped for the single nucleotide polymorphisms in the CFH (Y402H, rs1061170) and LOC387715/ARMS2 (A69S, rs10490924) genes.
|
18423869 |
2008 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in the LOC387715 (rs10490924), HTRA1 (rs11200638), and CFH (rs1061170) genes have been implicated in age-related macular degeneration (AMD).
|
18436811 |
2008 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped three SNPs, rs1061170 (exon 9, CFH), rs11200638 (HTRA1 promoter, -512 bp), and rs10490924 (6.6 kb upstream of HTRA1 in LOC387715/ARMS2) in 333 cases with advanced AMD (choroidal neovascularization [CNV] and geographic atrophy) and 171 age-matched examined controls.
|
18682806 |
2008 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Significant associations were detected for exudative AMD with SNPs rs10490924:G>T in LOC387715 (A69S), and rs11200638:G>A in the promoter of HTRA1.
|
18682812 |
2008 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs10490924 polymorphism, the major determinant of the 10q26 association with ARMD, determines the A69S substitution in the LOC387715/ARMS2 gene.
|
18688167 |
2008 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Homozygotes for the T allele of rs10490924 had an odds ratio (OR) of 8.6, with a 95% confidence interval (CI) of 3.5-20.8, and homozygotes for the A allele of rs11200638 had an OR of 10.7, with a 95% CI of 3.2-35.7, for having AMD (p<0.00001).
|
19065273 |
2008 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
SNP rs10490924 on chromosome 10 in exon 1 of the ARMS2 gene showed a highly significant association with an odds ratio (OR) of 3.2 (95% CI 2.4-4.2) for the risk allele and rs11200638 located in the proximal promoter region of HTRA1 showed a higher significant association with an OR of 3.4 (95% CI 2.5-4.6) with our AMD cases.
|
19259132 |
2009 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
One haplotype, which contained the T allele of the rs10490924 (A69S) and the variant of de1443ins54 polymorphism, had an odds ratio of 3.14 (P = 7.8 x 10(-6)) for AMD and 2.00 (P = .0058) for PCV.
|
19268887 |
2009 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We observed that homozygous risk genotypes (TT in rs10490924 and AA in rs11200638) were more strongly associated with AMD than the heterozygous genotypes (GT in rs10490924 and geographic atrophy in rs11200638) for both SNPs.
|
19491722 |
2009 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The specific functional role of ARMS2-rs10490924 remains as yet unknown, but it appears to mainly affect the progression to late AMD stages.
|
19797206 |
2010 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The six high-risk alleles all showed a statistically significant association with AMD (the most significant SNP was rs10490924 [P < or = 3.31 x 10(-5), OR = 1.86]; the least significant SNP was rs932275 [P < or = 9.15 x 10(-5), OR = 1.78]).
|
19933195 |
2010 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The lack of functional effects of the 3'UTR indel, the amino acid substitution of rs10490924 (A69S), and strong LD between them suggest that A69S, not the indel, is the variant that confers risk of AMD.
|
20182747 |
2010 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped two SNPs that are located in the LOC387715 locus (rs10490924) and HTRA1 (rs11200638) in 137 cases of exudative AMD and 187 controls.
|
20456446 |
2010 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The I62V and A69S polymorphisms were associated with all three subtypes: tAMD (P = 3.74 × 10(-18) and 1.</span>37 × 10(-35), respectively), PCV (P = 3.18 × 10(-19) and 3.96 × 10(-18), respectively), and RAP (P = 0.034 and 2.49 × 10(-18), respectively).
|
20574013 |
2010 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Multiple studies demonstrate a strong association between three variants at chromosome 10q26 - rs10490924, del443ins54, and rs11200638 - near the age-related maculopathy susceptibility 2 (ARMS2) and high-temperature requirement factor A1 (HTRA1) genes with susceptibility to age-related macular degeneration (AMD).
|
20664794 |
2010 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
A total of 1,080 patients with exudative AMD and 406 controls were recruited and genotyped for Y402H of complement factor H (CFH), rs10490924 of age-related maculopathy susceptibility 2 (ARMS2), and R102G of the C3 gene.
|
20664795 |
2010 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
HTRA1 rs11200638 G→A polymorphism and LOC387715/ARMS2 rs10490924 G→T polymorphism play important roles in AMD.
|
21031019 |
2010 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Common variants and haplotypes within the RORA gene appear to act synergistically with the ARMS2 A69S polymorphism to increase risk of neovascular AMD.
|
21060049 |
2010 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
To determine whether gene polymorphisms of the major genetic risk factor for age-related macular susceptibility 2 (ARMS2 A69S) and the complement factor H Y402H influence the response to a variable-dosing treatment regimen with ranibizumab for age-related macular degeneration.
|
21151600 |
2010 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The p.Ala69Ser polymorphism of the ARMS2 gene is strongly associated with exudative AMD and PCV and is associated marginally with dry AMD.
|
21236409 |
2011 |