rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
1093 patients with exudative AMD and 396 controls have been recruited and genotyped for the Y402H of CFH, rs10490924 of ARMS2 and T280M of the CX3CR1 gene.
|
21621535 |
2011 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
A significant genotype and variant allele association was found of rs10490924 in ARMS2/HTRA1 with wet AMD, while the SNPs in CFH, CFB, and C3 were not associated with AMD in the current Pakistani cohort.
|
30895599 |
2019 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
A total of 1,080 patients with exudative AMD and 406 controls were recruited and genotyped for Y402H of complement factor H (CFH), rs10490924 of age-related maculopathy susceptibility 2 (ARMS2), and R102G of the C3 gene.
|
20664795 |
2010 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
After adjusting for age, gender, ARMS2 A69S, and CFHI62V, the A allele of rs429608 was significantly protective against neovascular AMD (odds ratio [OR] 0.24, 95% confidence interval [CI] 0.122-0.484, p < 0.001), PCV (OR 0.43, 95% CI 0.262-0.704, p = 0.001), RAP (OR 0.09, 95% CI 0.014-0.581, p = 0.011).
|
24865191 |
2014 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
After adjusting for rs11200638, ARMS2 rs10490924 remained significantly associated with exudative AMD (P = 0.011), but not with PCV (P = 0.077).
|
22491416 |
2012 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
After multivariate adjustment, CFH Y402H and ARMS2 A69S polymorphisms were associated with very high risk for exudative AMD (OR = 6.21 and OR = 11.7, respectively, p < 0.0001).
|
24362810 |
2014 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Age and the T allele of ARMS2 A69S are the risk factors requiring retreatments, leading to poor visual change in eyes with exudative AMD following the initial 3-monthly IVR.
|
29045945 |
2018 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
ARMS2 A69S genotype is associated with second-eye involvement of exudative AMD and with the period between first- and second-eye involvements.
|
22809783 |
2012 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
ARMS2 rs10490924 was also significantly associated with the risk allele T found at a frequency of 0.5 in AMD and 0.15 in controls (p < 0.017, χ(2) test).
|
23362846 |
2013 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Association of combined cigarette smoking and ARMS2/LOC387715 A69S polymorphisms with age-related macular degeneration: A meta-analysis.
|
28095100 |
2017 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Association of Combined Complement Factor H Y402H and ARMS/LOC387715 A69S Polymorphisms with Age-related Macular Degeneration: A Meta-analysis.
|
27269047 |
2016 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Association of LOC387715/ARMS2 (rs10490924) Gene Polymorphism with Age-Related Macular Degeneration in the Brazilian Population.
|
24372405 |
2015 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Before the AMD clinical phenotype is present, those showing normal macular health with the ARMS2 A69S allele demonstrate delayed RMDA.
|
30389424 |
2019 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Blood samples from all subjects were genotyped for major age-related macular degeneration (AMD)-associated single nucleotide polymorphisms (SNPs) the major AMD-associated SNPs; CFH Y402H rs1061170, CFH I62V rs800292, ARMS2 A69S rs10490924.
|
30596689 |
2018 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Common variants and haplotypes within the RORA gene appear to act synergistically with the ARMS2 A69S polymorphism to increase risk of neovascular AMD.
|
21060049 |
2010 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Comparison of above-mentioned ORs revealed statistically higher values for GT and TT genotypes of ARMS2 A69S compared with CFH Y402H genotypes (p = 0.011, p = 0.014, respectively).Our analysis showed stronger contribution of ARMS2 in AMD with RPD group versus AMD without RPD group, in comparison with CFH genotypes.
|
28593728 |
2018 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Comparison of ARMS2/LOC387715 A69S and CFH Y402H risk effect in wet-type age-related macular degeneration: a meta-analysis.
|
29423786 |
2019 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Early identification of individuals with genetic risk variants CFH p.Y402H and ARMS2 p.A69S is clinically important for the definition of AMD status.
|
22706242 |
2012 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Exploring the association of rs10490924 polymorphism with age-related macular degeneration: An in silico approach.
|
28915445 |
2017 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Exploring the association of rs10490924 polymorphism with age-related macular degeneration: An in silico approach.
|
29316486 |
2018 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Female sex and the presence of both risk alleles of CFH-rs1061170 or ARMS2-rs10490924 were independently associated with early AMD incidence, whereas current smoking and presence of ≥1 risk allele of CFH-rs1061170 or ARMS2-rs10490924 were associated with late AMD incidence.
|
26383995 |
2015 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Furthermore, an independent association of C2/CFB variants was found for both typical AMD and PCV with age, sex, smoking, and genetic background of ARMS2 A69S and CFH I62V (vs. typical AMD: P = 0.0073, odds ratio [OR] = 0.47; vs. PCV: P = 0.0083, OR = 0.53).
|
22232432 |
2012 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genotype distributions of ARMS2 (A69S) and CFH (I62V) in patients with CVH and type 1 CNV significantly differed from those of AMD cases (P = 0.0014 and 0.0098, respectively), but not from general population controls (P = 0.33 and 0.82, statistical power of 88.5% and 72.9%, respectively).
|
24781946 |
2014 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Homozygotes for the T allele of rs10490924 had an odds ratio (OR) of 8.6, with a 95% confidence interval (CI) of 3.5-20.8, and homozygotes for the A allele of rs11200638 had an OR of 10.7, with a 95% CI of 3.2-35.7, for having AMD (p<0.00001).
|
19065273 |
2008 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, after Bonferroni correction, the genotype and allele distributions of two SNPs in CFH (rs10737680, rs1410996), one SNP (rs10490924) in ARMS2 and one SNP (rs11200638) in HTRA1 differed significantly between the controls and AMD patients.
|
24865190 |
2014 |