|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I/D gene polymorphism of the angiotensin-converting enzyme and M235T of angiotensinogen were ruled out as risk factors for hypertension.
|
23598646 |
2013 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Haplotype frequencies for M235T and G-6A were significantly different between hypertensive individuals and controls, which indicated an association of angiotensinogen gene haplotypes with hypertension, and a significant association of 235T/-6A haplotype with hypotensive effect.
|
15386947 |
2004 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study was undertaken to investigate the relationship of the M235T polymorphism of the AGT gene with left ventricular mass (LVM) and carotid intima-media thickness (IMT) in 175 Chinese patients with hypertension.
|
10342781 |
1999 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that the polymorphic variants of AGT gene-M235T and T174M-show association with hypertension.
|
22148914 |
2012 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
On the basis of likelihood ratio test, only the set of haplotypes that constituted the A-6G and the M235T polymorphisms was associated with hypertension (chi2 = 20.91, P = 0.0008), which was mainly due to the increased frequency of the recombinant haplotypes (-6A identical with 235M and -6G identical with 235T), and a pathophysiological role in the predisposition to hypertension was hence indicated.
|
14970360 |
2004 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Angiotensinogen T174M and M235T variants, sodium intake and hypertension among non-drinking, lean Japanese men and women.
|
10994750 |
2000 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A multiple logistic regression analysis showed that age (odds ratio [OR]: 1.07, 95% confidence interval [95% CI]: 1.06-1.08), body mass index (BMI) (OR: 1.18, 95% CI: 1.13-1.23), alcohol consumption (OR: 1.39, 95% CI: 1.16-1.66), family history of hypertension (OR: 1.57, 95% CI: 1.18-2.07), and combined AGT M235T Thr/Thr and ADD1 Trp/Trp polymorphisms (OR: 1.37, 95% CI: 1.03-1.82) were associated with hypertension.
|
16392768 |
2005 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The angiotensinogen M235T polymorphism has been linked to hypertension and cardiovascular disease.
|
11463770 |
2001 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
M235T polymorphism of the angiotensinogen gene and insertion/deletion polymorphism of the angiotensin-1 converting enzyme gene in essential arterial hypertension in Caucasians.
|
17448297 |
2007 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genotypic distribution of the Met235Thr (AGT) and Glu298Asp (NOS3) polymorphisms demonstrated that both are independent risk factors of hypertension (p=0.02 and p=0.008, respectively).
|
22791701 |
2013 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The M235T variant of the angiotensinogen gene is related to development of self-reported hypertension during pregnancy: the Prospect-EPIC cohort study.
|
18957799 |
2008 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The M235T and T174M variants, especially the T235 allele, contribute to an increased risk of hypertension in these Chinese patients.
|
20216084 |
2010 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ThrThr genotype of the angiotensinogen (AGT) Met235Thr polymorphism has been associated with elevated AGT levels, hypertension, increased heart disease risk, and improved blood pressure (BP) response to angiotensin-converting enzyme (ACE) inhibitors.
|
14643574 |
2003 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for the T allele of the M235T polymorphism of the angiotensinogen gene was associated with a 3.19-fold increased risk for lesion progression independently of arterial hypertension.
|
12456049 |
2002 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Angiotensinogen T174M and M235T variants and hypertension in the Hani and Yi minority groups of China.
|
19365726 |
2009 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study examined the SNPs AGT rs699 (Met235Thr), ADD1 rs4961 (Gly460Trp), NPPA rs5063 (Val32Met), GPX1 rs1050450 (Pro198Leu), and AGTR1 rs5186 (A1166C) in relation to hypertension and salt sensitivity.
|
27480094 |
2017 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The angiotensinogen M235T polymorphism is positively associated with plasma angiotensinogen, hypertension, and coronary heart disease.
|
12040348 |
2002 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Angiotensinogen M235T genotype was associated with a stepwise increase in angiotensinogen levels in white subjects and a corresponding increase in risk of hypertension in both white and Asian subjects.
|
12805070 |
2003 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association study of G(-6)A, A(-20)C and M235T variants in 111 hypertensives with strong family history and 190 normotensives with no family history showed significant linkage disequilibrium between particular haplotypes, but we could find no association with hypertension.
|
10528248 |
1999 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension, an important risk factor for the development and progression of diabetic nephropathy.
|
18413162 |
2008 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A DNA polymorphism which alters methionine to threonine at position 235 (M235T) within the angiotensinogen peptide has been associated previously with hypertension.
|
7635961 |
1995 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
M235T and T174M variants do not contribute to the increased risk of CHD or hypertension in the Indian population.
|
12938141 |
2003 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
M235T polymorphism of AGT has been studied extensively in many populations including Japanese, and the results suggest a weak, but significant linkage with hypertension.
|
11128865 |
2000 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
No association was observed between the M235T variant or 3'-microsatellite polymorphism of the AGT gene and hypertension.
|
10608470 |
1999 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The consistent relationships observed between the M235T variant and the protein product and between plasma level of the protein and hypertension status in different ethnic groups provide some evidence for a biochemical mechanism linking DNA variation in the renin-angiotensin system with the hypertension phenotype.
|
9170394 |
1997 |