|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the whole population blood pressure levels and prevalence of high blood pressure did not vary according to T174M and M235T genotypes.
|
7622852 |
1995 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A DNA polymorphism which alters methionine to threonine at position 235 (M235T) within the angiotensinogen peptide has been associated previously with hypertension.
|
7635961 |
1995 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
First, a contingency chi-square analysis was carried out to test for an association between the M235T polymorphism and hypertension status.
|
7649545 |
1995 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two mutations (T174M and M235T) in the angiotensinogen gene have been reported to be associated with hypertension.
|
7946168 |
1994 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The angiotensinogen gene has recently been linked with essential hypertension in affected sibships and a particular polymorphism in exon 2 of the angiotensinogen gene, a threonine to methionine substitution at position 235 (M235T), has been associated with pre-eclampsia and hypertension.
|
8523390 |
1995 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the angiotensinogen polymorphism M235T might influence susceptibility to nephropathy in insulin-dependent diabetes, but its effect, if any, is rather small and independent of hypertension.
|
8621207 |
1996 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings do not support the hypothesis that the M235T variant of the angiotensinogen gene is a risk factor for the development of post-transplant hypertension.
|
8856207 |
1996 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The data argue against a role of the angiotensinogen gene M235T polymorphism in the manifestation of diabetic nephropathy or hypertension in diabetic patients.
|
8918618 |
1996 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In studies conducted in several different populations, the M235T substitution in the angiotensinogen (AGT) locus has been associated with hypertension.
|
9034402 |
1997 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension, an important risk factor for the development and progression of diabetic nephropathy.
|
9049480 |
1997 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine whether the angiotensinogen M235T and angiotensin converting enzyme insertion/deletion (I/D) variants are related to the severity of hypertension in patients with established essential hypertension.
|
9170002 |
1997 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The consistent relationships observed between the M235T variant and the protein product and between plasma level of the protein and hypertension status in different ethnic groups provide some evidence for a biochemical mechanism linking DNA variation in the renin-angiotensin system with the hypertension phenotype.
|
9170394 |
1997 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied the relation between the M235T polymorphism of the angiotensinogen gene and hypertension using office and ambulatory (BP) measurements.
|
9194517 |
1997 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The haplotype combining the M235T and G-6A polymorphisms appears as the ancestral allele of the human AGT gene and as the one associated with hypertension.
|
9199566 |
1997 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The odds ratio for hypertension was 3.64 (95% confidence interval 1.56-8.49) for subjects with the C/C genotype of the M235T variant compared with other genotypes of 2.87 (95% confidence interval 1.76-4.68) for those carrying allele C versus those carrying allele T.
|
9218179 |
1997 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that C-18T polymorphism in AGCE1 is a genetic risk factor for essential hypertension in the Japanese and is more tightly and directly associated with hypertension than TT/M235T.
|
9314411 |
1997 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
M235T polymorphism of the angiotensinogen gene and hypertension in Chinese.
|
9794717 |
1998 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The formerly described, but controversial, association of the M235T polymorphism with arterial hypertension could not be confirmed in this study.
|
9950302 |
1999 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, this study provides no evidence that either allele of M235T or T174M contributes to hypertension in this Chinese population.
|
10024331 |
1999 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study was undertaken to investigate the relationship of the M235T polymorphism of the AGT gene with left ventricular mass (LVM) and carotid intima-media thickness (IMT) in 175 Chinese patients with hypertension.
|
10342781 |
1999 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
There are inconsistent reports that the angiotensinogen (ATG) variant Met235-->Thr (T235) allele and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) variants are associated with hypertension and related target organ damage.
|
10487325 |
1999 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The lack of a consistent association between M235T polymorphism at exon 2 and hypertension has suggested that another site in linkage disequilibrium with M235T is the causal mutation.
|
10489389 |
1999 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association study of G(-6)A, A(-20)C and M235T variants in 111 hypertensives with strong family history and 190 normotensives with no family history showed significant linkage disequilibrium between particular haplotypes, but we could find no association with hypertension.
|
10528248 |
1999 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
No association was observed between the M235T variant or 3'-microsatellite polymorphism of the AGT gene and hypertension.
|
10608470 |
1999 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a Dutch IDDM population, including 69 patients with (incipient) diabetic nephropathy, the T-allele of the AGT-M235T polymorphism is associated with an elevated UAE and diabetic retinopathy and the CC-genotype of the AT1-A1166C polymorphism is associated with hypertension.
|
10862638 |
2000 |