|
rs10811661
|
|
Diabetes
|
|
0.030 |
GeneticVariation
|
BEFREE |
There were potential interactions among CDKN2A/2B (rs10811661) - FTO (rs7195539) or FTO (rs7195539)-TG-HDL-family history of diabetes in the pathogenesis of T2D in a Uyghur population.
|
26873362 |
2016 |
|
rs10811661
|
|
Diabetes
|
|
0.030 |
GeneticVariation
|
BEFREE |
Pooling our results with those reported by the PROCARDIS group, we also obtained a significant result of association with diabetes for rs10811661 in the European population.
|
20403154 |
2010 |
|
rs10811661
|
|
Diabetes
|
|
0.030 |
GeneticVariation
|
BEFREE |
Islets from donors without diabetes (<i>n</i> = 95) were tested for SNP genotype (rs10811661, rs2383208, rs564398, and rs10757283), gene expression (<i>p14</i>, <i>p15</i>, <i>p16</i>, <i>MTAP</i>, <i>ANRIL</i>, <i>PCNA</i>, <i>KI67</i>, and <i>CCND2</i>), insulin secretion (<i>n</i> = 61), and β-cell proliferation (<i>n</i> = 47).
|
29432124 |
2018 |
|
rs7172432
|
|
Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
In the Danish MONICA study four gene variants were significantly associated with incident CVD independently of known diabetes status at baseline; SLC2A2 rs11920090 (HR 1.147, 95% CI 1.027-1.283 , P = 0.0154), C2CD4A rs7172432 (1.112, 1.027-1.205 , P = 0.0089), GCKR rs780094 (1.094, 1.007-1.188 , P = 0.0335) and C2CD4B rs11071657 (1.092, 1.007-1.183 , P = 0.0323).
|
23185617 |
2012 |
|
rs7172432
|
|
Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
We genotyped the rs7172432 variant in the population-based Inter99 cohort (n = 6,784) and analysed quantitative diabetes-related traits in 5,722 non-diabetic participants who all were examined by an OGTT.
|
21249489 |
2011 |
|
rs2327832
|
|
Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
Three single nucleotide polymorphisms were associated with increased diabetes risk (rs10517086_A [<i>P</i> = 0.03], rs1534422_G [<i>P</i> = 0.006], and rs2327832_G [<i>P</i> = 0.03] in <i>TNFAIP3</i>) and one with decreased risk (rs1004446_A in <i>INS</i> [<i>P</i> = 0.006]).
|
28903990 |
2017 |
|
rs2327832
|
|
Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
Moreover, we identify the single nucleotide polymorphism rs2327832 of TNFAIP3 as a possible prognostic marker for diabetes outcome in children with T1D.
|
26652732 |
2016 |
|
rs17782313
|
|
Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
We tested the hypothesis that the ADRB2rs1800888(Thr164Ile) polymorphism associates with risk of obesity and diabetes and compared effect sizes with those of FTO(rs9939609), MC4R(rs17782313), and TMEM18(rs6548238).
|
22466342 |
2012 |
|
rs17782313
|
|
Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
We examined the associations of the reported variants rs17782313 (T>C) and rs17700633 (G>A) with dietary intakes, weight change and diabetes risk in 5724 women (1533 with type 2 diabetes) from a prospective cohort.
|
18697794 |
2008 |
|
rs12779790
|
|
Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
Another diabetes susceptibility locus (rs12779790) located between the calcium/calmodulin-dependent protein kinase ID (CAMK1D) and cell division cycle 123 homolog (CDC123) genes is also associated with both macroscopic (OR = 1.40, p = 0.0292) and microscopic infarcts (OR = 1.43, p = 0.0285).
|
24135527 |
2013 |
|
rs12779790
|
|
Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
Homozygous carriers of the minor diabetes risk G-allele of the CDC123/CAMK1D rs12779790 showed an 18% decrease in insulinogenic index (95% CI 10-27%; P = 4 x 10(-5)), an 18% decrease in corrected insulin response (CIR) (8.1-29%; P = 4 x 10(-4)), and a 13% decrease in the ratio of area under the serum-insulin and plasma-glucose curves during an OGTT (AUC-insulin/AUC-glucose) (5.8-20%; P = 4 x 10(-4)).
|
18567820 |
2008 |
|
rs944289
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
We also observed an interaction (P = 0.029; OR = 2.578, 95% CI = 1.104 - 6.023) between rs944289 and diabetes in patients with PTC.
|
24452548 |
2014 |
|
rs9402571
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs9402571 SGK genotype associates with increased insulin secretion in lean non-diabetic TUEF/EUGENE2 participants and with lower diabetes prevalence in METSIM.
|
18985156 |
2008 |
|
rs8099917
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Univariate analysis revealed that, compared to patients without advanced liver fibrosis, patients with advanced liver fibrosis (Metavir fibrosis score 3-4) had an older age, a lower platelet count, a higher α-fetoprotein level, a higher alanine aminotransferase level, a higher incidence of diabetes, and a higher frequency of rs8099917 non-TT genotype carriage.Logistic regression analysis revealed that factors significantly associated with advanced liver fibrosis included age (odds ratio [OR]/95% confidence interval [CI]: 1.023/1.009-1.037, P = .001), diabetes (OR/CI: 1.736/1.187-2.539, P = .004), α-fetoprotein (OR/CI: 1.007/1.002-1.012, P = .009), platelet count (OR/CI: 0.991/0.988-0.993, P < .001), and carriage of the rs8099917 non-TT genotype (OR/CI: 0.585/0.400-0.856, P = .006).
|
29517696 |
2018 |
|
rs7936247
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Compared with women with a family history of diabetes, there was a significant association of rs7936247 with GDM risk among pregnant women without a family history of diabetes (OR 1.20; 95% CI 1.04-1.38; P = 0.014; P<sub>heterogeneity</sub> = 0.035).
|
30912250 |
2019 |
|
rs7923837
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
T2D-related variants HHEX rs7923837, TCF7L2 rs290481 and CDKAL1 rs7756992 increased cancer risk in patients with diabetes.
|
24468095 |
2014 |
|
rs7910977
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype CT from rs6583813-rs7910977 was protective against diabetes (P=0.02).
|
24477584 |
2014 |
|
rs7193788
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was an interaction between rs7193788 and diabe</span>tes (P = 0.036).
|
28245897 |
2017 |
|
rs6834314
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
We used instrumental variable analysis based on two single nucleotide polymorphism (SNPs) HSD17B13/MAPK10 (rs6834314) and PNPLA3/SAMM50 (rs738409) to assess the associations of ALT (U/L) with IHD, diabetes and other CVD risk factors in the Guangzhou Biobank Cohort Study (GBCS).
|
28007909 |
2017 |
|
rs675209
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Model covariates, age (P = 5.95E-06), sex (P = 2.46E-39), diabetes (P = 2.34E-07), BMI (P = 1.14E-11) and the SNPs, rs1967017 (P = 9.54E-03), rs13129697 (P = 4.34E-07), rs2199936 (P = 7.28E-03) and rs675209 (P = 4.84E-02) were all associated with incident gout.
|
26427508 |
2016 |
|
rs6681231
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rare G allele of htSNP rs6681231 was associated with aggressive periodontitis prior to and after adjustment for the covariates smoking, diabetes, and gender, with an odds ratio of 1.57 (95% confidence interval 1.18-2.08; p = 0.002).
|
20177132 |
2010 |
|
rs6583813
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype CT from rs6583813-rs7910977 was protective against diabetes (P=0.02).
|
24477584 |
2014 |
|
rs6564851
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
We next used a triangulation approach to estimate the expected effect of rs6564851 on type 2 diabetes risk and compared this with the observed effect using data from 4549 type 2 diabetes patients and 5579 controls from the Diabetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium.
|
19662379 |
2009 |
|
rs6548238
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
We tested the hypothesis that the ADRB2rs1800888(Thr164Ile) polymorphism associates with risk of obesity and diabetes and compared effect sizes with those of FTO(rs9939609), MC4R(rs17782313), and TMEM18(rs6548238).
|
22466342 |
2012 |
|
rs6499863
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three SNPs, at CETP, KLF14 and HNF4A, associated with type 2 diabetes only in female participants with the HDL-C-lowering allele increasing diabetes risk (p values: 3.2 × 10(-4) to 7.7 × 10(-5)); the association remained significant even after adjustment for HDL-C. Additional analysis across CETP identified rs6499863 as having the strongest association with type 2 diabetes in female participants (p = 5.0 × 10(-6)) and this association remained independent of the HDL-C association.
|
26670163 |
2016 |