|
rs57922
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
A genome-wide association study in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial identified two markers (rs57922 and rs9299870) that were significantly associated with cardiovascular mortality during intensive glycemic control and could potentially be used, when combined into a genetic risk score (GRS), to identify patients with diabetes likely to derive benefit from intensive control rather than harm.
|
29183908 |
2018 |
|
rs5015480
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the combined effect of smoking on the relationship between HHEX rs5015480 and diabetes.
|
29720110 |
2018 |
|
rs4900384
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
In stratified analyses by age, glucose AUC, age at screening, sibling, HLA genotypes, rs6476839 (GLIS3), and rs4900384 (C14orf64) were significantly associated with progression to diabetes in participants <12 years old, whereas glucose AUC, sibling, rs3184504 (SH2B3), and rs4900384 (C14orf64) were significant in those ≥12.
|
28520980 |
2017 |
|
rs4810479
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Triglyceride levels (P = 0.0042), diabetes (P = 7.28 × 10(-5)), paraoxonase 1 (PON1) activity (P = 0.019), statin use (P = 0.026), PLTP SNP rs4810479 (P = 6.38 × 10(-7)), and PCIF1 SNP rs181914932 (P = 0.041) were all significantly associated with PLTPa.
|
26009633 |
2015 |
|
rs2943641
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of allelic variants in rs2681472 and rs2681492 with hypertension, rs987237 and rs7826222 with waist circumference and rs864745, rs7578597 and rs2943641 with diabetes were not significant.
|
23036851 |
2013 |
|
rs2863389
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Seventy-eight SNPs were nominally associated with diabetes in one other 100K GWA scan, and two (rs2863389 and rs7935082) in more than one.
|
17848626 |
2007 |
|
rs267734
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, we found that rs267734 in CERS2 is associated with rate of increase in albuminuria among patients with diabetes and elevated risk of cardiovascular disease.
|
25238615 |
2014 |
|
rs2383208
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Islets from donors without diabetes (<i>n</i> = 95) were tested for SNP genotype (rs10811661, rs2383208, rs564398, and rs10757283), gene expression (<i>p14</i>, <i>p15</i>, <i>p16</i>, <i>MTAP</i>, <i>ANRIL</i>, <i>PCNA</i>, <i>KI67</i>, and <i>CCND2</i>), insulin secretion (<i>n</i> = 61), and β-cell proliferation (<i>n</i> = 47).
|
29432124 |
2018 |
|
rs2111485
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Islet autoantibody-positive children with the IFIH1 rs2111485 GG genotype had a faster progression to diabetes (31% within 5 years) than children with the type 1 diabetes protective GA or AA genotypes (11% within 5 years; P = 0.006).
|
21270278 |
2011 |
|
rs1967017
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Model covariates, age (P = 5.95E-06), sex (P = 2.46E-39), diabetes (P = 2.34E-07), BMI (P = 1.14E-11) and the SNPs, rs1967017 (P = 9.54E-03), rs13129697 (P = 4.34E-07), rs2199936 (P = 7.28E-03) and rs675209 (P = 4.84E-02) were all associated with incident gout.
|
26427508 |
2016 |
|
rs181914932
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Triglyceride levels (P = 0.0042), diabetes (P = 7.28 × 10(-5)), paraoxonase 1 (PON1) activity (P = 0.019), statin use (P = 0.026), PLTP SNP rs4810479 (P = 6.38 × 10(-7)), and PCIF1 SNP rs181914932 (P = 0.041) were all significantly associated with PLTPa.
|
26009633 |
2015 |
|
rs1800592
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
A total of 792 patients with T2DM were enrolled and categorized into two groups: (1) the DR group consisted of 448 patients, which was further subclassified into a proliferative DR (PDR) group with 220 patients and a non-proliferative DR (NPDR) group with 228 patients; (2) the diabetes without retinopathy (DNR) group, comprised 344 patients who had no signs of DR. Single-nucleotide polymorphisms (SNPs), rs1800592 in the UCP1 gene, rs1801282, rs3856806 and rs1249719 in the PPARγ gene and rs11196205 in the TCF7L2 gene were genotyped in this study.
|
25274455 |
2015 |
|
rs17700633
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the associations of the reported variants rs17782313 (T>C) and rs17700633 (G>A) with dietary intakes, weight change and diabetes risk in 5724 women (1533 with type 2 diabetes) from a prospective cohort.
|
18697794 |
2008 |
|
rs1543654
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
In joint analysis of 90,003 IBC and Cardiometabochip SNPs, rs1543654 in the region of KCNE1 predicted change in BDI scores at Year 1 in diabetes support and education (β = -1.05, standard error [SE] = 0.21, p = 6.9 × 10(-7)) at the level of chip-wide significance, while also showing a nominal association with baseline BDI (β = 0.35, SE = 0.16, p = .026).
|
26489030 |
2016 |
|
rs1387153
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
In European populations, the rs1387153 T allele is associated with increased FPG (beta = 0.06 mmol/l, P = 7.6 x 10(-29), N = 16,094), type 2 diabetes (T2D) risk (odds ratio (OR) = 1.15, 95% CI = 1.08-1.22, P = 6.3 x 10(-5), cases N = 6,332) and risk of developing hyperglycemia or diabetes over a 9-year period (hazard ratio (HR) = 1.20, 95% CI = 1.06-1.36, P = 0.005, incident cases N = 515).
|
19060909 |
2009 |
|
rs12980275
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Patients who have favorable AA IL28B alleles have a lower prevalence of diabetes and related complications compared with patients with unfavorable IL28B rs12980275 genotype.
|
25663241 |
2015 |
|
rs12910524
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicated that the rs12910524 in the Tanis gene was associated with triglyceride concentrations in subjects without diabetes in China.
|
23829426 |
2013 |
|
rs1260236
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among whites, rs34459162, a novel missense single nucleotide polymorphism (SNP) in <i>RCN3</i>, was associated with fructosamine (<i>P</i> = 5.3 × 10<sup>-9</sup>) and rs1260236, a known diabetes-related missense mutation in <i>GCKR</i>, was associated with percent glycated albumin (<i>P</i> = 5.9 × 10<sup>-9</sup>) and replicated in CARDIA.
|
29844224 |
2018 |
|
rs12513649
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
CREBRF rs12513649 and rs373863828 were genotyped in 2022 participants in a community-based cross-sectional study designed to identify determinants of diabetes and end-stage renal disease (ESRD).
|
31280340 |
2019 |
|
rs12363572
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the A allele of rs3758644 was related to decreased fasting plasma insulin and homeostatic model assessment of β-cell function levels, whereas the T allele of rs12363572 was related to increased high-density lipoprotein cholesterol levels in new-onset diabetes patients (P < 0.05).
|
28067456 |
2017 |
|
rs12229654
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three gene variants, rs12229654, rs17249754, and rs11066280, were significantly associated with metabolic disorders such as hyperlipidemia and diabetes (P = 0.00071 to 0.0097, respectively).
|
24142389 |
2014 |
|
rs1206634
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Regarding the rs1206634 T→G variant, heterozygous patients had a higher systolic blood pressure (P=0.039), higher prevalence of diabetes (P=0.010), and higher total cholesterol levels (P=0.006) compared to homozygotes.
|
23869418 |
2013 |
|
rs11206510
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed suggestive associations with the diabetes risk variant rs7961581 (p = 0.038; between TSPAN8 and LGR5) and rs5215 (p = 0.043; KCNJ11), the LDL risk variant rs11206510 (p = 0.045; PCSK9), as well as the AF risk locus ZFHX3.
|
24135527 |
2013 |
|
rs11071657
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the Danish MONICA study four gene variants were significantly associated with incident CVD independently of known diabetes status at baseline; SLC2A2 rs11920090 (HR 1.147, 95% CI 1.027-1.283 , P = 0.0154), C2CD4A rs7172432 (1.112, 1.027-1.205 , P = 0.0089), GCKR rs780094 (1.094, 1.007-1.188 , P = 0.0335) and C2CD4B rs11071657 (1.092, 1.007-1.183 , P = 0.0323).
|
23185617 |
2012 |
|
rs10885390
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, we identified a common protective haplotype defined by these four SNPs that was significantly associated with type 2 diabetes and age at diagnosis (P = 4.2 x 10(-5), relative risk [RR] 0.69; P = 6.7 x 10(-6), respectively) and a haplotype that confers diabetes risk that contains the rare alleles at SNPs rs10885390 and rs12255372 (P = 0.02, RR 1.64).
|
17259383 |
2007 |