|
rs20417
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Variant alleles at two markers, rs20417 and rs2066826, which are located in the promoter and intron 6, respectively, were in strong linkage disequilibrium with each other (D'=0.97) and were associated with a higher prevalence of T2DM.
|
12920574 |
2003 |
|
rs20417
|
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
We evaluated two PTGS2 (rs20417, rs689470), and three PTGER2 (rs708494/uS5, rs708495/uS7, and chr14: 50 764 013/uS10) gene polymorphisms among 600 Caucasian male participants of the Physicians' Health Study with incident myocardial infarction (MI) or ischemic stroke and 600 age- and smoking-matched controls who remained free of all reported cardiovascular disease.
|
16879213 |
2006 |
|
rs20417
|
|
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
We evaluated two PTGS2 (rs20417, rs689470), and three PTGER2 (rs708494/uS5, rs708495/uS7, and chr14: 50 764 013/uS10) gene polymorphisms among 600 Caucasian male participants of the Physicians' Health Study with incident myocardial infarction (MI) or ischemic stroke and 600 age- and smoking-matched controls who remained free of all reported cardiovascular disease.
|
16879213 |
2006 |
|
rs20417
|
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
We evaluated two PTGS2 (rs20417, rs689470), and three PTGER2 (rs708494/uS5, rs708495/uS7, and chr14: 50 764 013/uS10) gene polymorphisms among 600 Caucasian male participants of the Physicians' Health Study with incident myocardial infarction (MI) or ischemic stroke and 600 age- and smoking-matched controls who remained free of all reported cardiovascular disease.
|
16879213 |
2006 |
|
rs20417
|
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
A secondary aim was to replicate the interaction of PTGS2 rs20417 (-765G to C) with aspirin use on coronary heart disease risk observed in the Atherosclerosis Risk in Communities Study (ARIC).
|
19046748 |
2009 |
|
rs20417
|
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
A secondary aim was to replicate the interaction of PTGS2 rs20417 (-765G to C) with aspirin use on coronary heart disease risk observed in the Atherosclerosis Risk in Communities Study (ARIC).
|
19046748 |
2009 |
|
rs20417
|
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
A secondary aim was to replicate the interaction of PTGS2 rs20417 (-765G to C) with aspirin use on coronary heart disease risk observed in the Atherosclerosis Risk in Communities Study (ARIC).
|
19046748 |
2009 |
|
rs20417
|
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
We replicated the observation of the Atherosclerosis Risk in Communities Study and observed an interaction of rs20417 with aspirin use on myocardial infarction risk (p for interaction=0.03).
|
19046748 |
2009 |
|
rs20417
|
|
Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We replicated the observation of the Atherosclerosis Risk in Communities Study and observed an interaction of rs20417 with aspirin use on myocardial infarction risk (p for interaction=0.03).
|
19046748 |
2009 |
|
rs20417
|
|
Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We replicated the observation of the Atherosclerosis Risk in Communities Study and observed an interaction of rs20417 with aspirin use on myocardial infarction risk (p for interaction=0.03).
|
19046748 |
2009 |
|
rs20417
|
|
Stage IV Gallbladder Cancer AJCC v8
|
|
0.020 |
GeneticVariation
|
BEFREE |
We aimed to evaluate the role of PTGS2 -1195G>A [reference sequence (rs) 689466], -765G>C (rs20417) and +8473T>C (rs5275) polymorphisms in conferring interindividual susceptibility to gallbladder cancer.
|
19455278 |
2009 |
|
rs20417
|
|
Malignant neoplasm of gallbladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
We aimed to evaluate the role of PTGS2 -1195G>A [reference sequence (rs) 689466], -765G>C (rs20417) and +8473T>C (rs5275) polymorphisms in conferring interindividual susceptibility to gallbladder cancer.
|
19455278 |
2009 |
|
rs20417
|
|
Gallbladder Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We aimed to evaluate the role of PTGS2 -1195G>A [reference sequence (rs) 689466], -765G>C (rs20417) and +8473T>C (rs5275) polymorphisms in conferring interindividual susceptibility to gallbladder cancer.
|
19455278 |
2009 |
|
rs20417
|
|
Stage IIB Gallbladder Cancer AJCC v8
|
|
0.020 |
GeneticVariation
|
BEFREE |
We aimed to evaluate the role of PTGS2 -1195G>A [reference sequence (rs) 689466], -765G>C (rs20417) and +8473T>C (rs5275) polymorphisms in conferring interindividual susceptibility to gallbladder cancer.
|
19455278 |
2009 |
|
rs20417
|
|
Stage III Gallbladder Cancer AJCC v8
|
|
0.020 |
GeneticVariation
|
BEFREE |
We aimed to evaluate the role of PTGS2 -1195G>A [reference sequence (rs) 689466], -765G>C (rs20417) and +8473T>C (rs5275) polymorphisms in conferring interindividual susceptibility to gallbladder cancer.
|
19455278 |
2009 |
|
rs20417
|
|
Stage 0 Gallbladder Cancer AJCC v8
|
|
0.020 |
GeneticVariation
|
BEFREE |
We aimed to evaluate the role of PTGS2 -1195G>A [reference sequence (rs) 689466], -765G>C (rs20417) and +8473T>C (rs5275) polymorphisms in conferring interindividual susceptibility to gallbladder cancer.
|
19455278 |
2009 |
|
rs20417
|
|
Stage IIA Gallbladder Cancer AJCC v8
|
|
0.020 |
GeneticVariation
|
BEFREE |
We aimed to evaluate the role of PTGS2 -1195G>A [reference sequence (rs) 689466], -765G>C (rs20417) and +8473T>C (rs5275) polymorphisms in conferring interindividual susceptibility to gallbladder cancer.
|
19455278 |
2009 |
|
rs20417
|
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We analyzed in Spanish population the risk contribution and the prognostic significance for colorectal cancer (CRC) with five polymorphisms (rs20417, rs20426, rs5276, rs13306035 and rs4648298) located in the coding and regulatory regions of COX2.
|
19468846 |
2009 |
|
rs20417
|
|
Prostate carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found no evidence that rs20417</span> alters prostate cancer</span> risk (odds</span> ratio (OR(CC & GC v GG)=1.05, 95% confidence interval (CI)=0.91-1.20).
|
19488068 |
2009 |
|
rs20417
|
|
Malignant neoplasm of prostate
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found no evidence that rs20417</span> alters prostate cancer</span> risk (odds</span> ratio (OR(CC & GC v GG)=1.05, 95% confidence interval (CI)=0.91-1.20).
|
19488068 |
2009 |
|
rs20417
|
|
Adenoma of large intestine
|
|
0.010 |
GeneticVariation
|
BEFREE |
The polymorphism, -899G>C (rs20417), alters a transcription factor-binding site and is associated with a reduced risk of colorectal adenoma.
|
19488068 |
2009 |
|
rs20417
|
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
In conclusion, the present meta-analysis suggests that none of the most studied three SNPs (rs5275, rs20417, and rs5277) in the COX-2 gene is a conspicuous low-penetrant risk factor for developing breast cancer.
|
20033767 |
2010 |
|
rs20417
|
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
In conclusion, the present meta-analysis suggests that none of the most studied three SNPs (rs5275, rs20417, and rs5277) in the COX-2 gene is a conspicuous low-penetrant risk factor for developing breast cancer.
|
20033767 |
2010 |
|
rs20417
|
|
Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The validation of the association of rs20417 by the htSNP rs6681231 provides evidence for a general genetic risk of COX-2 variants in the pathogenesis of periodontitis.
|
20177132 |
2010 |
|
rs20417
|
|
Degenerative polyarthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The promoter polymorphism rs20417 of the COX-2 gene contributes to the genetic risk for end-stage hip and knee OA.
|
20378913 |
2011 |