|
rs20417
|
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis showed that COX-2 rs20417 polymorphism was correlated with an increased risk of breast cancer in Caucasians, while rs689466 was associated with a decreased risk of breast cancer in Caucasians.
|
25214704 |
2014 |
|
rs20417
|
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
In conclusion, the present meta-analysis suggests that none of the most studied three SNPs (rs5275, rs20417, and rs5277) in the COX-2 gene is a conspicuous low-penetrant risk factor for developing breast cancer.
|
20033767 |
2010 |
|
rs20417
|
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis showed that COX-2 rs20417 polymorphism was correlated with an increased risk of breast cancer in Caucasians, while rs689466 was associated with a decreased risk of breast cancer in Caucasians.
|
25214704 |
2014 |
|
rs20417
|
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
COX-2-rs20417 CC genotype was significantly associated with increased risk of breast cancer when comparing to G allele [ORs were 1.231 (1.050-1.444) for CC vs. GG, P = 0.01, 1.223 (1.045-1.432) for CC vs. G carrier, P = 0.01].
|
25433948 |
2015 |
|
rs20417
|
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
COX-2-rs20417 CC genotype was significantly associated with increased risk of breast cancer when comparing to G allele [ORs were 1.231 (1.050-1.444) for CC vs. GG, P = 0.01, 1.223 (1.045-1.432) for CC vs. G carrier, P = 0.01].
|
25433948 |
2015 |
|
rs20417
|
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
In conclusion, the present meta-analysis suggests that none of the most studied three SNPs (rs5275, rs20417, and rs5277) in the COX-2 gene is a conspicuous low-penetrant risk factor for developing breast cancer.
|
20033767 |
2010 |
|
rs20417
|
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our results indicate no strong association between three most frequent COX-2 SNPs rs689465 rs689466, rs20417 studied with breast cancer risk in the single locus analysis.
|
24789723 |
2015 |
|
rs20417
|
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our results indicate no strong association between three most frequent COX-2 SNPs rs689465 rs689466, rs20417 studied with breast cancer risk in the single locus analysis.
|
24789723 |
2015 |
|
rs20417
|
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Here, we evaluate the impact of the four most common cyclooxygenase-2 gene polymorphisms (rs689465, rs689466, rs20417 and rs20417), in combination with obesity, on the risk of breast cancer progression in a cohort of Brazilian breast cancer patients (<i>N</i> = 1038).
|
29321183 |
2018 |
|
rs20417
|
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
Here, we evaluate the impact of the four most common cyclooxygenase-2 gene polymorphisms (rs689465, rs689466, rs20417 and rs20417), in combination with obesity, on the risk of breast cancer progression in a cohort of Brazilian breast cancer patients (<i>N</i> = 1038).
|
29321183 |
2018 |
|
rs20417
|
|
Malignant neoplasm of prostate
|
|
0.040 |
GeneticVariation
|
BEFREE |
When all groups were pooled, we did not detect a significant association of rs20417 polymorphism with prostate cancer risk.
|
22782583 |
2012 |
|
rs20417
|
|
Prostate carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In a hospital-based case/control study, 195 subjects with PCa and 250 healthy controls were investigated for the association of COX-2 -765 G>C (rs20417) and +8473 T>C (rs5275) promoter polymorphism with PCa susceptibility using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method.
|
22023987 |
2011 |
|
rs20417
|
|
Prostate carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found no evidence that rs20417</span> alters prostate cancer</span> risk (odds</span> ratio (OR(CC & GC v GG)=1.05, 95% confidence interval (CI)=0.91-1.20).
|
19488068 |
2009 |
|
rs20417
|
|
Prostate carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between the cyclooxygenase 2 (COX2) -765G>C (rs20417) polymorphism and prostate cancer (PC) risk using meta-analysis.
|
26535654 |
2015 |
|
rs20417
|
|
Malignant neoplasm of prostate
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found no evidence that rs20417</span> alters prostate cancer</span> risk (odds</span> ratio (OR(CC & GC v GG)=1.05, 95% confidence interval (CI)=0.91-1.20).
|
19488068 |
2009 |
|
rs20417
|
|
Malignant neoplasm of prostate
|
|
0.040 |
GeneticVariation
|
BEFREE |
In a hospital-based case/control study, 195 subjects with PCa and 250 healthy controls were investigated for the association of COX-2 -765 G>C (rs20417) and +8473 T>C (rs5275) promoter polymorphism with PCa susceptibility using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method.
|
22023987 |
2011 |
|
rs20417
|
|
Prostate carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
When all groups were pooled, we did not detect a significant association of rs20417 polymorphism with prostate cancer risk.
|
22782583 |
2012 |
|
rs20417
|
|
Malignant neoplasm of prostate
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between the cyclooxygenase 2 (COX2) -765G>C (rs20417) polymorphism and prostate cancer (PC) risk using meta-analysis.
|
26535654 |
2015 |
|
rs20417
|
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
We investigated five variants (rs5788, rs1330344, rs3842788, rs20417, and rs689466) of two COX genes in order to explaining the association between these polymorphisms and we also investigated the association between these variants and ischemic stroke risk to determine whether gene-gene interaction between these genes increases the susceptibility of ischemic stroke or its subtypes.
|
31735164 |
2019 |
|
rs20417
|
|
Cerebrovascular accident
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the Brazilian cohort, rs20417 polymorphism was associated with both stroke (P = 5 × 10(-6)) and decreased PGE2 levels (P = 4 × 10(-5)); similarly, Chagas was associated with stroke (P = 4 × 10(-3)) and decreased PGE2 levels (P = 7 × 10(-3)).
|
25957909 |
2015 |
|
rs20417
|
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
A secondary aim was to replicate the interaction of PTGS2 rs20417 (-765G to C) with aspirin use on coronary heart disease risk observed in the Atherosclerosis Risk in Communities Study (ARIC).
|
19046748 |
2009 |
|
rs20417
|
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Among patients with previous coronary artery disease (CAD), rs20417 carriers had a stronger protective effect on risk of major adverse events when compared with individuals without previous CAD (interaction P-value: 0.015).
|
24796340 |
2014 |
|
rs20417
|
|
Cerebrovascular accident
|
|
0.030 |
GeneticVariation
|
BEFREE |
This is the first study to demonstrate associations between stroke functional outcome and 2 COX-2 variants (rs20417 and rs5275) and a GPIIIa variant (rs5918).
|
20472470 |
2011 |
|
rs20417
|
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
We evaluated two PTGS2 (rs20417, rs689470), and three PTGER2 (rs708494/uS5, rs708495/uS7, and chr14: 50 764 013/uS10) gene polymorphisms among 600 Caucasian male participants of the Physicians' Health Study with incident myocardial infarction (MI) or ischemic stroke and 600 age- and smoking-matched controls who remained free of all reported cardiovascular disease.
|
16879213 |
2006 |
|
rs20417
|
|
Liver carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Functional coding region polymorphisms -1195A>G (rs689466), -765G>C (rs20417), and +8473T>C (rs5275) in the COX-2 gene have recently been shown to be associated with several human cancers but their association with HCC has yet to be investigated.
|
21042835 |
2011 |