|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Variants in CFH rs1410996, ARMS2/HTRA1 A69S, and C3 R102G were significantly associated with an increased risk of AMD.
|
21906714 |
2011 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
To determine whether gene polymorphisms of the major genetic risk factor for age-related macular susceptibility 2 (ARMS2 A69S) and the complement factor H Y402H influence the response to a variable-dosing treatment regimen with ranibizumab for age-related macular degeneration.
|
21151600 |
2010 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
ARMS2 A69S genotype is associated with second-eye involvement of exudative AMD and with the period between first- and second-eye involvements.
|
22809783 |
2012 |
|
rs10490924
|
|
Age related macular degeneration
|
T |
0.900 |
GeneticVariation
|
GWASDB |
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
|
21665990 |
2011 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Before the AMD clinical phenotype is present, those showing normal macular health with the ARMS2 A69S allele demonstrate delayed RMDA.
|
30389424 |
2019 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We confirmed the association of age-related maculopathy susceptibility 2 (ARMS2) rs10490924 (P=7.38 × 10<sup>-17</sup>), HTRA1 rs11200638 (P=5.47 × 10<sup>-17</sup>) and complement factor H gene (CFH) rs800292 (P=2.53 × 10<sup>-8</sup>) with neovascular AMD, all loci passing the genome-wide significance level (P<5.22 × 10<sup>-8</sup>).
|
28703135 |
2017 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
To describe the relationships of risk alleles in complement factor H (CFH, rs1061170) and age-related maculopathy susceptibility 2 (ARMS2, rs10490924) to the incidence and progression of age-related macular degeneration (AMD) during a 20-year period.
|
23494043 |
2013 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Common variants and haplotypes within the RORA gene appear to act synergistically with the ARMS2 A69S polymorphism to increase risk of neovascular AMD.
|
21060049 |
2010 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Age and the T allele of ARMS2 A69S are the risk factors requiring retreatments, leading to poor visual change in eyes with exudative AMD following the initial 3-monthly IVR.
|
29045945 |
2018 |
|
rs10490924
|
|
Age related macular degeneration
|
A |
0.900 |
GeneticVariation
|
GWASDB |
Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis.
|
23577725 |
2013 |
|
rs10490924
|
|
Age related macular degeneration
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
|
21665990 |
2011 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The HTRA1 promoter SNP (rs11200638) and A69S at LOC387715/ARMS2 were associated with a poorer visual outcome for ranibizumab or bevacizumab treatment in neovascular AMD, suggesting strong pharmacogenetic associations with anti-VEGF treatment.
|
23582991 |
2013 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The ARMS2 protein is absent in monocytes and also in microglia cells, derived from patients homozygous for the ARMS2 AMD risk variant (rs10490924).
|
28086806 |
2017 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
GWASDB |
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
|
23326517 |
2013 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The risk alleles C in CFH rs1061170 (p < 0.0001, Pearson chi-square) and T in ARMS2 rs10490924 (p < 0.0001), as well as smoking (p < 0.0001), were more prevalent in AMD patients compared with controls.
|
26154559 |
2015 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between the genotype of ARMS2 rs10490924 polymorphism and IVR treatment responsiveness in patients with neovascular AMD.
|
28002601 |
2016 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Comparison of above-mentioned ORs revealed statistically higher values for GT and TT genotypes of ARMS2 A69S compared with CFH Y402H genotypes (p = 0.011, p = 0.014, respectively).Our analysis showed stronger contribution of ARMS2 in AMD with RPD group versus AMD without RPD group, in comparison with CFH genotypes.
|
28593728 |
2018 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Second, in support of previous reports we also show that the ARMS2 rs10490924:T allele is significantly linked to exsudative AMD.
|
23103884 |
2013 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Using DNA extracted from venous blood of 876 white participants in AREDS categories 3 and 4, that is, those considered to be at high risk for progression to advanced AMD, the authors genotyped for the single nucleotide polymorphisms in the CFH (Y402H, rs1061170) and LOC387715/ARMS2 (A69S, rs10490924) genes.
|
18423869 |
2008 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The ARMS2 A69S substitution may serve as a marker for bilateral advanced AMD.
|
22481475 |
2012 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our meta-analysis provides substantial evidence that the ARMS2 A69S variant confers a significantly higher risk of neovascular AMD than PCV.
|
22219653 |
2011 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, after Bonferroni correction, the genotype and allele distributions of two SNPs in CFH (rs10737680, rs1410996), one SNP (rs10490924) in ARMS2 and one SNP (rs11200638) in HTRA1 differed significantly between the controls and AMD patients.
|
24865190 |
2014 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
SNP rs10490924 on chromosome 10 in exon 1 of the ARMS2 gene showed a highly significant association with an odds ratio (OR) of 3.2 (95% CI 2.4-4.2) for the risk allele and rs11200638 located in the proximal promoter region of HTRA1 showed a higher significant association with an OR of 3.4 (95% CI 2.5-4.6) with our AMD cases.
|
19259132 |
2009 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The six high-risk alleles all showed a statistically significant association with AMD (the most significant SNP was rs10490924 [P < or = 3.31 x 10(-5), OR = 1.86]; the least significant SNP was rs932275 [P < or = 9.15 x 10(-5), OR = 1.78]).
|
19933195 |
2010 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Homozygotes for the T allele of rs10490924 had an odds ratio (OR) of 8.6, with a 95% confidence interval (CI) of 3.5-20.8, and homozygotes for the A allele of rs11200638 had an OR of 10.7, with a 95% CI of 3.2-35.7, for having AMD (p<0.00001).
|
19065273 |
2008 |