rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
After multivariate adjustment, CFH Y402H and ARMS2 A69S polymorphisms were associated with very high risk for exudative AMD (OR = 6.21 and OR = 11.7, respectively, p < 0.0001).
|
24362810 |
2014 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The I62V and A69S polymorphisms were associated with all three subtypes: tAMD (P = 3.74 × 10(-18) and 1.</span>37 × 10(-35), respectively), PCV (P = 3.18 × 10(-19) and 3.96 × 10(-18), respectively), and RAP (P = 0.034 and 2.49 × 10(-18), respectively).
|
20574013 |
2010 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Association of Combined Complement Factor H Y402H and ARMS/LOC387715 A69S Polymorphisms with Age-related Macular Degeneration: A Meta-analysis.
|
27269047 |
2016 |
rs10490924
|
|
Age related macular degeneration
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
We confirmed the association of age-related maculopathy susceptibility 2 (ARMS2) rs10490924 (P=7.38 × 10<sup>-17</sup>), HTRA1 rs11200638 (P=5.47 × 10<sup>-17</sup>) and complement factor H gene (CFH) rs800292 (P=2.53 × 10<sup>-8</sup>) with neovascular AMD, all loci passing the genome-wide significance level (P<5.22 × 10<sup>-8</sup>).
|
28703135 |
2017 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs10490924 polymorphism, the major determinant of the 10q26 association with ARMD, determines the A69S substitution in the LOC387715/ARMS2 gene.
|
18688167 |
2008 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The specific functional role of ARMS2-rs10490924 remains as yet unknown, but it appears to mainly affect the progression to late AMD stages.
|
19797206 |
2010 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Logistic regression analysis revealed a relationship between the rs10490924 polymorphism and AMD in the Turkish population.
|
28128407 |
2017 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Multiple studies demonstrate a strong association between three variants at chromosome 10q26 - rs10490924, del443ins54, and rs11200638 - near the age-related maculopathy susceptibility 2 (ARMS2) and high-temperature requirement factor A1 (HTRA1) genes with susceptibility to age-related macular degeneration (AMD).
|
20664794 |
2010 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
A total of 1,080 patients with exudative AMD and 406 controls were recruited and genotyped for Y402H of complement factor H (CFH), rs10490924 of age-related maculopathy susceptibility 2 (ARMS2), and R102G of the C3 gene.
|
20664795 |
2010 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Blood samples from all subjects were genotyped for major age-related macular degeneration (AMD)-associated single nucleotide polymorphisms (SNPs) the major AMD-associated SNPs; CFH Y402H rs1061170, CFH I62V rs800292, ARMS2 A69S rs10490924.
|
30596689 |
2018 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The ARMS2/HTRA1 genes at the 10q26 locus have been associated with risk of age-related macular degeneration (AMD), with the most significantly associated variants being A69S (rs10490924), del443ins54 (EU427539) and rs11200638.
|
23592919 |
2013 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population.
|
21909106 |
2011 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Comparison of ARMS2/LOC387715 A69S and CFH Y402H risk effect in wet-type age-related macular degeneration: a meta-analysis.
|
29423786 |
2019 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Sub-analysis demonstrated that women with ARMS2 A69S polymorphisms had a stronger risk for early AMD (OR: 3.25, 95% CI: 2.10-5.04) than men (OR: 1.65, 95% CI: 1.02-2.69).
|
29335418 |
2018 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Patients were genotyped to identify major single nucleotide polymorphisms associated with AMD (CFH Y402, CFH I62V, and ARMS2 A69S).
|
27521170 |
2016 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Their genetic susceptibility to AMD was significantly lower than that of neovascular AMD; ARMS2 rs10490924 (p = 0.029), CFH rs800292 (p = 0.013) and genetic risk score calculated from 11 AMD susceptibility genes (p = 3.8 × 10(-3)).
|
26542071 |
2015 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, weak correlations between 10 SNPs (CFH rs1329428 TT genotype, CFH rs3753394 CC genotype and T allele, CFH rs1410996 AA genotype, CFH rs800292 AA genotype, CFH rs800292 A allele, VEGF rs833061 TT genotype and C allele, VEGF rs2010963 CG genotype, VEGFR2 rs1531289 TT genotype, ARMS2 rs10490924 TT genotype, KCTD10 rs238104 GC genotype, rs1531289 T allele and ARMS2 rs10490924 T allele) and AMD were shown.
|
30696427 |
2019 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Two SNPs generated highly significant allelic associations with PCV (rs10490924, P = 5.7 x 10(-6); rs11200638, P = 5.2 x 10(-6)) and AMD (rs10490924, P = 1.4 x 10(-6); rs11200638, P = 3.4 x 10(-7)).
|
17692272 |
2007 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The highest risk was observed in those doubly homozygous for rs10490924</span> and rs1061170 in CFH (OR, 62.3; 95% confidence interval, 16-242), with P values for trend ranging from 0.03 (early AMD, stage 1) to 1 × 10(-26) (late AMD).
|
23098369 |
2013 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
This was true for all AMD subtype analyses of both rs800292 (complement factor H) and rs10490924 (ARMS2).
|
22065928 |
2011 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The lack of functional effects of the 3'UTR indel, the amino acid substitution of rs10490924 (A69S), and strong LD between them suggest that A69S, not the indel, is the variant that confers risk of AMD.
|
20182747 |
2010 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|
20385826 |
2010 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Furthermore, an independent association of C2/CFB variants was found for both typical AMD and PCV with age, sex, smoking, and genetic background of ARMS2 A69S and CFH I62V (vs. typical AMD: P = 0.0073, odds ratio [OR] = 0.47; vs. PCV: P = 0.0083, OR = 0.53).
|
22232432 |
2012 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We propose that rs10490924 represents a major susceptibility variant for AMD at 10q26.
|
17884985 |
2007 |
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|
20385826 |
2010 |