|
rs267608078
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
AC |
0.700 |
CausalMutation
|
CLINVAR |
No association between MUTYH and MSH6 germline mutations in 64 HNPCC patients.
|
18301448 |
2008 |
|
rs267608078
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
AC |
0.700 |
CausalMutation
|
CLINVAR |
Germline mutations in a polycytosine repeat of the hMSH6 gene in Korean hereditary nonpolyposis colorectal cancer.
|
9929971 |
1999 |
|
rs267608092
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
C |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs267608094
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
T |
0.700 |
CausalMutation
|
CLINVAR |
Prevalence of alterations in DNA mismatch repair genes in patients with young-onset colorectal cancer.
|
21056691 |
2011 |
|
rs267608094
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
T |
0.700 |
CausalMutation
|
CLINVAR |
Current clinical criteria for Lynch syndrome are not sensitive enough to identify MSH6 mutation carriers.
|
20587412 |
2010 |
|
rs267608094
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
T |
0.700 |
CausalMutation
|
CLINVAR |
Compound heterozygosity for two MSH6 mutations in a patient with early onset of HNPCC-associated cancers, but without hematological malignancy and brain tumor.
|
16418736 |
2006 |
|
rs267608098
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
G |
0.700 |
GeneticVariation
|
CLINVAR |
Risks of Lynch syndrome cancers for MSH6 mutation carriers.
|
20028993 |
2010 |
|
rs267608098
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
G |
0.700 |
GeneticVariation
|
CLINVAR |
Germ-line msh6 mutations in colorectal cancer families.
|
10537275 |
1999 |
|
rs267608120
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
A |
0.700 |
CausalMutation
|
CLINVAR |
Characterization of two Ashkenazi Jewish founder mutations in MSH6 gene causing Lynch syndrome.
|
21155762 |
2011 |
|
rs267608120
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
A |
0.700 |
CausalMutation
|
CLINVAR |
Risks of Lynch syndrome cancers for MSH6 mutation carriers.
|
20028993 |
2010 |
|
rs267608120
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
A |
0.700 |
CausalMutation
|
CLINVAR |
Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers.
|
12732731 |
2003 |
|
rs267608121
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
ATCAG |
0.700 |
CausalMutation
|
CLINVAR |
The gastrointestinal manifestation of constitutional mismatch repair deficiency syndrome: from a single adenoma to polyposis-like phenotype and early onset cancer.
|
25307252 |
2015 |
|
rs267608121
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
ATCAG |
0.700 |
CausalMutation
|
CLINVAR |
Identification of germline genetic mutations in patients with pancreatic cancer.
|
26440929 |
2015 |
|
rs267608121
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
ATCAG |
0.700 |
CausalMutation
|
CLINVAR |
Genetic and clinical determinants of constitutional mismatch repair deficiency syndrome: report from the constitutional mismatch repair deficiency consortium.
|
24440087 |
2014 |
|
rs267608121
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
ATCAG |
0.700 |
CausalMutation
|
CLINVAR |
Characterization of two Ashkenazi Jewish founder mutations in MSH6 gene causing Lynch syndrome.
|
21155762 |
2011 |
|
rs267608121
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
ATCAG |
0.700 |
CausalMutation
|
CLINVAR |
An Ashkenazi founder mutation in the MSH6 gene leading to HNPCC.
|
19851887 |
2010 |
|
rs267608121
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
ATCAG |
0.700 |
CausalMutation
|
CLINVAR |
MSH6 germline mutations are rare in colorectal cancer families.
|
14520694 |
2003 |
|
rs267608122
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.
|
26681312 |
2016 |
|
rs267608122
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population.
|
24728189 |
2014 |
|
rs267608122
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database.
|
24362816 |
2014 |
|
rs267608122
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Challenges in the identification of MSH6-associated colorectal cancer: rectal location, less typical histology, and a subset with retained mismatch repair function.
|
21836479 |
2011 |
|
rs267608122
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Risks of Lynch syndrome cancers for MSH6 mutation carriers.
|
20028993 |
2010 |
|
rs267608122
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Major contribution from recurrent alterations and MSH6 mutations in the Danish Lynch syndrome population.
|
18566915 |
2009 |
|
rs267608122
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Patients with an unexplained microsatellite instable tumour have a low risk of familial cancer.
|
17453009 |
2007 |
|
rs267608122
|
|
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance.
|
15236168 |
2004 |