|
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
CD susceptibility polymorphisms ATG16L1 rs2241880, ICAM1 rs5498, IL4 rs2070874, IL17F rs763780, IRGM rs13361189, ITLN1 rs2274910, LRRK2 rs11175593, and TLR4 rs4986790 were genotyped in a Portuguese population (511 CD patients, 626 controls) and assessed for association with CD clinical characteristics.
|
22573572 |
2013 |
|
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
TLR4 variant D299G showed significant association, with UC (P=0.009) and CD (P=0.039).
|
23470644 |
2013 |
|
rs4986790
|
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
BEFREE |
In this two-center, retrospective German and Hungarian cohort study, patients with Crohn's disease (CD) (n = 379; German n = 235, Hungarian n = 144) and ulcerative colitis (UC) (n = 263; German n = 145, Hungarian n = 118) and healthy controls (n = 605; German n = 403, Hungarian n = 202) were genotyped for the presence of the CD14 c.1-260C>T promoter variant and the TLR4 c.896A>G (p.D299G) variant by melting curve analysis using fluorescence resonance energy transfer probes.
|
18174680 |
2007 |
|
rs4986790
|
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
BEFREE |
In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp, Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.
|
15655821 |
2005 |
|
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
In a geographic area in Southern Italy with high incidence of CD we investigated IP (lactulose/mannitol testing) together with the three main mutations of the NOD2/CARD15 and the D299G polymorphism of the toll-like receptor (TLR)-4 gene in 23 families of CD patients (patients and first-degree relatives).
|
16393227 |
2005 |
|
rs4986790
|
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the clinical characteristics and frequency of TLR4 polymorphisms (Asp299Gly and Thr 399Ile) in a cohort of Brazilian patients with AS.
|
27692393 |
2018 |
|
rs4986790
|
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
BEFREE |
The minor allele frequency for the Asp299Gly variant (G) was significantly higher in AS cases compared to controls (7.5% vs 2.6%, respectively; OR 3.10, p = 0.037).
|
17143969 |
2007 |
|
rs4986790
|
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
BEFREE |
The present study might suggest that TLR4 D299G/T399I polymorphisms are not associated with RA/AS susceptibility.
|
22717291 |
2012 |
|
rs4986790
|
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
BEFREE |
Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms do not contribute to disease susceptibility in either AS or ReA.
|
16567359 |
2006 |
|
rs4986790
|
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
BEFREE |
No significant difference between the frequencies of the Asp299Gly genotype or the Thr399Ile genotype between patients with AS and healthy HLA-B27 controls was found.
|
16837493 |
2006 |
|
rs4986790
|
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
BEFREE |
There is no evidence for involvement of the CD14 C-260T or TLR4 A896G polymorphisms in susceptibility to AS.
|
15647432 |
2005 |
|
rs4986790
|
|
Psoriasis
|
|
0.710 |
GeneticVariation
|
BEFREE |
Significant association was observed between a missense variant rs4986790 of TLR4 (Asp229Gly) and plaque type psoriasis (p = 2 × 10(-4)) which was also notable in those with psoriatic arthritis (p = 2 × 10(-4)) and early-onset psoriasis (p = 8 × 10(-4)).
|
26830904 |
2016 |
|
rs4986791
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations between TLR4 Thr399Ile polymorphisms and CD risk were found only in the allele and dominant models.
|
26023918 |
2015 |
|
rs4986791
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggests that TLR4 T399I polymorphism is moderately associated with susceptibility to CD, and more studies are needed to confirm our conclusion.
|
29421805 |
2018 |
|
rs4986791
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide polymorphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007finsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy.
|
18680223 |
2008 |
|
rs4986791
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two polymorphisms of TLR4 (D299G, T399I) gene were genotyped by PCR-RFLP in 199 UC, 46 Crohn's disease (CD) patients, and 201 healthy controls.
|
23470644 |
2013 |
|
rs4986791
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped and tested for case-control frequency differences in a New Zealand white cohort of 389 Crohn's disease (CD) patients, 405 ulcerative colitis (UC) patients, and 416 population controls.
|
17850411 |
2007 |
|
rs4986791
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, meta-analysis demonstrated significantly higher frequencies of both Asp299Gly and Thr399Ile SNPs in IBD and CD and for 399Ileu carriage in UC patients.
|
25492126 |
2014 |
|
rs4986791
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The presence of TLR-4 Asp299Gly and TLR-4 Thr399Ile polymorphisms is related to UC pancolitis, involvement of the colon in CD, and lower ACCA IgA levels.
|
22918682 |
2013 |
|
rs4986791
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease.
|
15973118 |
2005 |
|
rs4986791
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
90 patients with CD and 80 healthy individuals are genotyped for the Asp299Gly and Thr399Ile polymorphisms by restriction fragment length polymorphism analysis.
|
19664207 |
2009 |
|
rs4986791
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Asp299Gly and Thr399Ile variants do not show an association with CD, UC, or IBD as a group, indicating that these polymorphisms are likely not the causal ones.
|
15905704 |
2005 |
|
rs4986791
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analysis showed that TLR4 D299G and T399I confer a significant risk for developing CD and UC in Caucasians.
|
20093834 |
2010 |
|
rs4986791
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp, Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.
|
15655821 |
2005 |
|
rs4986791
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms of NOD2 (R702W, G908R and L1007fs) and TLR4 (Asp299Gly and Thr399Ile) genes were analyzed in 106 patients with IBD (68 with ulcerative colitis [UC], 38 with Crohn's disease [CD]) and 160 healthy controls using polymerase chain reaction-restriction fragment length polymorphism.
|
29055077 |
2017 |