rs4986790
|
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
BEFREE |
Polymorphisms of NOD2 (R702W, G908R and L1007fs) and TLR4 (Asp299Gly and Thr399Ile) genes were analyzed in 106 patients with IBD (68 with ulcerative colitis [UC], 38 with Crohn's disease [CD]) and 160 healthy controls using polymerase chain reaction-restriction fragment length polymorphism.
|
29055077 |
2017 |
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Polymorphisms of NOD2 (R702W, G908R and L1007fs) and TLR4 (Asp299Gly and Thr399Ile) genes were analyzed in 106 patients with IBD (68 with ulcerative colitis [UC], 38 with Crohn's disease [CD]) and 160 healthy controls using polymerase chain reaction-restriction fragment length polymorphism.
|
29055077 |
2017 |
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
D299G and T399I were related to CD only in patients carrying NOD2 variants (NOD2+/TLR4+ haplotype) (p=0.036; OR=1.924), increasing the risk to develop CD when 1007insC and TLR4 variants were both present (OR=4.886).
|
27290609 |
2016 |
rs4986790
|
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
BEFREE |
The meta-analysis provides evidence that TLR2 Arg753Gln is not associated with CD and UC susceptibility in Asians; TLR4 Asp299Gly is associated with CD and UC susceptibility in Caucasians, but not Asians.
|
26023918 |
2015 |
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
The meta-analysis provides evidence that TLR2 Arg753Gln is not associated with CD and UC susceptibility in Asians; TLR4 Asp299Gly is associated with CD and UC susceptibility in Caucasians, but not Asians.
|
26023918 |
2015 |
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Toll-like receptor (TLR) polymorphisms, and especially TLR-4 Asp299Gly and TLR-4 Thr399Ile, have been linked with Crohn's disease (CD) and to a lesser extent with ulcerative colitis (UC), CD behavior, and compromised seroreactivity to microbial antigens.
|
22918682 |
2013 |
rs4986790
|
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
BEFREE |
TLR4 variant D299G showed significant association, with UC (P=0.009) and CD (P=0.039).
|
23470644 |
2013 |
rs4986790
|
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
BEFREE |
The presence of TLR-4 Asp299Gly and TLR-4 Thr399Ile polymorphisms is related to UC pancolitis, involvement of the colon in CD, and lower ACCA IgA levels.
|
22918682 |
2013 |
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
CD susceptibility polymorphisms ATG16L1 rs2241880, ICAM1 rs5498, IL4 rs2070874, IL17F rs763780, IRGM rs13361189, ITLN1 rs2274910, LRRK2 rs11175593, and TLR4 rs4986790 were genotyped in a Portuguese population (511 CD patients, 626 controls) and assessed for association with CD clinical characteristics.
|
22573572 |
2013 |
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
TLR4 variant D299G showed significant association, with UC (P=0.009) and CD (P=0.039).
|
23470644 |
2013 |
rs4986790
|
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
BEFREE |
Overall, no heterozygous or homozygous single nucleotide polymorphism mutations were found in patients with Crohn's disease and ulcerative colitis both in the TLR4 gene Asp299Gly, Thr399Ile and the TLR2 gene Arg677Trp, Arg753Gln in the Zhuang population from the Guangxi Zhuang Autonomous Region of China.
|
23239925 |
2012 |
rs4986790
|
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
BEFREE |
The meta-analysis showed that TLR4 D299G and T399I confer a significant risk for developing CD and UC in Caucasians.
|
20093834 |
2010 |
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
The meta-analysis showed that TLR4 D299G and T399I confer a significant risk for developing CD and UC in Caucasians.
|
20093834 |
2010 |
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
90 patients with CD and 80 healthy individuals are genotyped for the Asp299Gly and Thr399Ile polymorphisms by restriction fragment length polymorphism analysis.
|
19664207 |
2009 |
rs4986790
|
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
BEFREE |
To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide polymorphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007finsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy.
|
18680223 |
2008 |
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Australian population.
|
18213697 |
2008 |
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
To examine whether TLR4 Asp299Gly, CD14-260C/T, TNF-1031T/C, TNF-863C/A, TNF-857C/T, TACE-172C/T, and TACE-154C/A polymorphisms are associated with Crohn disease in the Ashkenazi Jewish population, we analyzed families with at least 1 child with Crohn disease for association with these mutations using a family-based association test (transmission disequilibrium test) for analysis.
|
18493210 |
2008 |
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide polymorphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007finsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy.
|
18680223 |
2008 |
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
In this two-center, retrospective German and Hungarian cohort study, patients with Crohn's disease (CD) (n = 379; German n = 235, Hungarian n = 144) and ulcerative colitis (UC) (n = 263; German n = 145, Hungarian n = 118) and healthy controls (n = 605; German n = 403, Hungarian n = 202) were genotyped for the presence of the CD14 c.1-260C>T promoter variant and the TLR4 c.896A>G (p.D299G) variant by melting curve analysis using fluorescence resonance energy transfer probes.
|
18174680 |
2007 |
rs4986790
|
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
BEFREE |
The TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped and tested for case-control frequency differences in a New Zealand white cohort of 389 Crohn's disease (CD) patients, 405 ulcerative colitis (UC) patients, and 416 population controls.
|
17850411 |
2007 |
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
The meta-analysis provides evidence that Asp299Gly is associated with CD and IBD in whites.
|
17850411 |
2007 |
rs4986790
|
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
BEFREE |
In this two-center, retrospective German and Hungarian cohort study, patients with Crohn's disease (CD) (n = 379; German n = 235, Hungarian n = 144) and ulcerative colitis (UC) (n = 263; German n = 145, Hungarian n = 118) and healthy controls (n = 605; German n = 403, Hungarian n = 202) were genotyped for the presence of the CD14 c.1-260C>T promoter variant and the TLR4 c.896A>G (p.D299G) variant by melting curve analysis using fluorescence resonance energy transfer probes.
|
18174680 |
2007 |
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp, Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.
|
15655821 |
2005 |
rs4986790
|
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
BEFREE |
Using a polymerase chain reaction based restriction fragment length polymorphism, the study genotyped polymorphisms TLR4 Asp299Gly and CD14 C-260T in 114 patients with UC and 160 healthy controls in the Chinese Han population.
|
16085746 |
2005 |
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
The TLR4 Asp299Gly polymorphism is a risk factor for CD.
|
15973118 |
2005 |