|
rs4986790
|
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
A TDT on 318 IBD trios demonstrated preferential transmission of the TLR4 Asp299Gly polymorphism from heterozygous parents to affected children (T/U: 68/34, p = 0.01).
|
15194649 |
2004 |
|
rs4986790
|
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated, by using a polymerase chain reaction restriction-fragment length polymorphism method, the possible association between the polymorphisms of TLR2 (Arg677Trp and Arg753Gln) and TLR4 (Asp299Gly and Thr399Ile) genes with the susceptibility or severity of RA and SLE.
|
14651524 |
2004 |
|
rs4986790
|
|
Atherosclerosis
|
|
0.090 |
GeneticVariation
|
BEFREE |
The presence of the Asp299Gly allele of the TLR4 gene does not seem to exert a major influence on the progression of atherosclerosis in patients with FH.
|
14764071 |
2004 |
|
rs4986790
|
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
|
0.090 |
GeneticVariation
|
BEFREE |
The association of the TLR4 mutations (Asp299Gly and Thr399Ile) and the CD14/-159 polymorphism were analyzed in 99 infants hospitalized with severe RSV bronchiolitis (group I).
|
15143473 |
2004 |
|
rs4986790
|
|
Arteriosclerosis
|
|
0.090 |
GeneticVariation
|
BEFREE |
The presence of the Asp299Gly allele of the TLR4 gene does not seem to exert a major influence on the progression of atherosclerosis in patients with FH.
|
14764071 |
2004 |
|
rs4986790
|
|
Periodontitis
|
|
0.090 |
GeneticVariation
|
BEFREE |
The prevalence of the Asp299Gly and the Thr399Ile mutant allele was 4.1% (10/244) and 4.5% (11/244) among periodontitis patients.
|
14738464 |
2004 |
|
rs4986790
|
|
Coronary Artery Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes.
|
15632890 |
2004 |
|
rs4986790
|
|
Coronary heart disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
The TLR4/Asp299Gly and CD14/C-260T polymorphisms and plasma sCD14 concentrations do not appear as significant predictors of the risk of CHD in healthy individuals.
|
15367917 |
2004 |
|
rs4986790
|
|
Myocardial Infarction
|
|
0.080 |
GeneticVariation
|
BEFREE |
Using TaqMan PCR technology, we determined the prevalence of the Asp299Gly and Thr399Ile polymorphisms in the TLR4 gene, and their association with MI in a study of 1213 survivors of a first MI and 1561 controls from the Stockholm region.
|
15302104 |
2004 |
|
rs4986790
|
|
Coronary heart disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes.
|
15632890 |
2004 |
|
rs4986790
|
|
Asthma
|
|
0.080 |
GeneticVariation
|
BEFREE |
The TLR4 (Asp299Gly) polymorphism was associated with a 4-fold higher prevalence of asthma in school-aged children (adjusted odds ratio 4.5, 95% CI 1.1-17.4) but not to allergic rhinoconjunctivitis.
|
15356557 |
2004 |
|
rs4986791
|
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
|
0.070 |
GeneticVariation
|
BEFREE |
The association of the TLR4 mutations (Asp299Gly and Thr399Ile) and the CD14/-159 polymorphism were analyzed in 99 infants hospitalized with severe RSV bronchiolitis (group I).
|
15143473 |
2004 |
|
rs4986791
|
|
Periodontitis
|
|
0.060 |
GeneticVariation
|
BEFREE |
The prevalence of the Asp299Gly and the Thr399Ile mutant allele was 4.1% (10/244) and 4.5% (11/244) among periodontitis patients.
|
14738464 |
2004 |
|
rs4986790
|
|
Tuberculosis, Pulmonary
|
|
0.060 |
GeneticVariation
|
BEFREE |
To determine whether TLR4 Asp299Gly influences LPS responses or susceptibility to pulmonary TB in humans in a Gambian population sample.
|
15525557 |
2004 |
|
rs4986790
|
|
Tuberculosis
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our data suggest that TLR4 Asp299Gly has no influence on monocyte LPS responses or susceptibility to TB in Gambians and could be an ancient neutral polymorphism.
|
15525557 |
2004 |
|
rs4986790
|
|
Coronary Arteriosclerosis
|
|
0.060 |
GeneticVariation
|
BEFREE |
Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes.
|
15632890 |
2004 |
|
rs4986791
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes.
|
14693986 |
2004 |
|
rs4986791
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
We studied the prevalence of two common polymorphisms of the TLR4 gene (Asp299Gly and Thr399Ile) in 3 independent study populations: (1.) in a cross-sectional study including 769 patients either with type 1 or type 2 diabetes mellitus, of whom 56 (7.2%) had a history of cerebral ischemia (study 1), (2.) a case-control study (study 2) including 128 consecutive patients with cerebral ischemia, mean age 60 +/- 10.9 years and 139 control subjects, and (3.) a case-control study (study 3) including 171 young adults aged < 50 years with cerebral ischemia and 204 control individuals.
|
15258789 |
2004 |
|
rs4986791
|
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
We found no statistically significant differences in the TLR4-Asp299Gly and the TLR4-Thr399Ile genotype or allele distribution between SLE patients, RA patients, and control individuals.
|
14651524 |
2004 |
|
rs4986790
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes.
|
14693986 |
2004 |
|
rs4986791
|
|
Rheumatoid Arthritis
|
|
0.040 |
GeneticVariation
|
BEFREE |
We investigated, by using a polymerase chain reaction restriction-fragment length polymorphism method, the possible association between the polymorphisms of TLR2 (Arg677Trp and Arg753Gln) and TLR4 (Asp299Gly and Thr399Ile) genes with the susceptibility or severity of RA and SLE.
|
14651524 |
2004 |
|
rs4986790
|
|
Lupus Erythematosus, Systemic
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found no statistically significant differences in the TLR4-Asp299Gly and the TLR4-Thr399Ile genotype or allele distribution between SLE patients, RA patients, and control individuals.
|
14651524 |
2004 |
|
rs4986790
|
|
Carotid Atherosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
This implies that the Asp299Gly TLR4-allele might have a protective role in carotid atherosclerosis, but not in cerebral ischemia.
|
15258789 |
2004 |
|
rs4986790
|
|
Diabetes Mellitus
|
|
0.030 |
GeneticVariation
|
BEFREE |
Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes.
|
15632890 |
2004 |
|
rs4986790
|
|
Bronchiolitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Each of the TLR4 mutations, either alone or in cosegregation, were associated with severe RSV bronchiolitis: the Asp299Gly and Thr399Ile mutations were significantly overrepresented in group I, compared with groups II and III.
|
15143473 |
2004 |