|
rs11536879
|
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs11536879</span> and rs11536889 polymorphisms of TLR4 gene and serum TLR4 protein levels may contribute to the occurrence and development of CAD.
|
31082501 |
2019 |
|
rs11536889
|
|
Pneumonia, Ventilator-Associated
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings indicated the regulatory association of miR-1236 with TLR4 and the abnormal expression of TLR4 caused by the presence of rs11536889 in the 3'-UTR of mRNA, which interfere with its interaction with the miR-1236, contributing to the risk of VAP.
|
30972742 |
2019 |
|
rs11536889
|
|
Parkinson Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, we did not find any significant association of rs4986791 and rs11536889 with PD susceptibility after covariates adjustment for age, sex, smoking, alcohol drinking and BMI.
|
30594449 |
2019 |
|
rs11536889
|
|
Intracranial Aneurysm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicated TLR4 SNP rs11536889 may be a marker for IA risk, though the exact functional roles of TLR4 SNP rs11536889 in IA formation are still not very clear.
|
29754966 |
2018 |
|
rs11536889
|
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aimed to evaluate the association of the toll-like receptor 4 (TLR4) polymorphisms rs1927914, rs10759932, and rs11536889 with susceptibility to ischemic stroke (IS) and the serum levels of inflammatory cytokines.
|
29075930 |
2018 |
|
rs11536889
|
|
Hematologic Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
We retrospectively examined whether or not genetic variations in toll-like receptor 1 (rs5743551, -7202GQ>A), toll-like receptor 2 (rs7656411, 22215G>T), and toll-like receptor 4 (rs11536889, +3725G>C) affected transplant outcomes in a cohort of 365 patients who underwent unrelated HLA-matched bone marrow transplantation (for hematologic malignancies through the Japan Marrow Donor Program.
|
28484092 |
2017 |
|
rs11536889
|
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Toll-like receptor 4 rs11536889 is associated with angiographic extent and severity of coronary artery disease in a Chinese population.
|
28002812 |
2017 |
|
rs11536889
|
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Toll-like receptor 4 rs11536889 is associated with angiographic extent and severity of coronary artery disease in a Chinese population.
|
28002812 |
2017 |
|
rs11536889
|
|
Glaucoma, Primary Open Angle
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs11536889 polymorphism was not associated to POAG in any case.
|
27892755 |
2017 |
|
rs11536889
|
|
Complete atrioventricular block
|
|
0.010 |
GeneticVariation
|
BEFREE |
The SNPs associated with HCC risk in patients with cirrhosis and CHB were rs11536889 in TLR4 and rs2853744 in SPP1.
|
27391584 |
2016 |
|
rs11536889
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The SNPs associated with HCC risk in patients with cirrhosis and CHB were rs11536889 in TLR4 and rs2853744 in SPP1.
|
27391584 |
2016 |
|
rs11536889
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
In female participants, rs10759932, rs1927911 and rs11536889 were associated with type 2 diabetes (odds ratio 1.176, P = 0.002 for rs10759932, odds ratio 1.136, P = 0.009 for rs1927911, odds ratio 0.882, P = 0.024 for rs11536889).
|
25104099 |
2015 |
|
rs11536889
|
|
Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have previously shown that a single nucleotide polymorphism rs11536889 in the 3'-untranslated region (UTR) of TLR4 was associated with periodontitis.
|
22661708 |
2012 |
|
rs11536889
|
|
Neutropenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four SNPs in the TLR4 gene (rs10759931, rs11536889, rs1927911 and rs6478317) were associated with an increased risk of developing chemotherapy-induced neutropenia, each sustaining correction for multiple testing.
|
21403649 |
2011 |
|
rs11536889
|
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aimed to examine the associations of the miR-146a G/C (rs2910164) and TLR4 +3725 G/C (rs11536889) polymorphisms with the risk of Helicobacter pylori (H. pylori) infection, gastric atrophy, and gastric cancer in a Japanese population.
|
20721625 |
2011 |
|
rs11536889
|
|
Leukopenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four SNPs in the TLR4 gene (rs10759931, rs11536889, rs1927911 and rs6478317) were associated with an increased risk of developing chemotherapy-induced neutropenia, each sustaining correction for multiple testing.
|
21403649 |
2011 |
|
rs11536891
|
|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two CRP haplotypes (global p = 0.04) and TLR4 tagSNPs (rs7873784, rs11536891), but not TLR4 haplotypes, were associated with colorectal cancer.
|
19760027 |
2009 |
|
rs11536891
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
To evaluate the association of TLR4 polymorphisms and the risk for PC in Korean men, we genotyped five single-nucleotide polymorphisms (SNPs) of the TRL4 gene (rs11536858, rs1927914, 1927911, rs11536891, and rs11536897) by PCR-restriction fragment length polymorphism from unrelated 157 PC patients and 143 age-matched controls.
|
19380025 |
2009 |
|
rs11536891
|
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
To evaluate the association of TLR4 polymorphisms and the risk for PC in Korean men, we genotyped five single-nucleotide polymorphisms (SNPs) of the TRL4 gene (rs11536858, rs1927914, 1927911, rs11536891, and rs11536897) by PCR-restriction fragment length polymorphism from unrelated 157 PC patients and 143 age-matched controls.
|
19380025 |
2009 |
|
rs11536891
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two CRP haplotypes (global p = 0.04) and TLR4 tagSNPs (rs7873784, rs11536891), but not TLR4 haplotypes, were associated with colorectal cancer.
|
19760027 |
2009 |
|
rs11536897
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
To evaluate the association of TLR4 polymorphisms and the risk for PC in Korean men, we genotyped five single-nucleotide polymorphisms (SNPs) of the TRL4 gene (rs11536858, rs1927914, 1927911, rs11536891, and rs11536897) by PCR-restriction fragment length polymorphism from unrelated 157 PC patients and 143 age-matched controls.
|
19380025 |
2009 |
|
rs11536897
|
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
To evaluate the association of TLR4 polymorphisms and the risk for PC in Korean men, we genotyped five single-nucleotide polymorphisms (SNPs) of the TRL4 gene (rs11536858, rs1927914, 1927911, rs11536891, and rs11536897) by PCR-restriction fragment length polymorphism from unrelated 157 PC patients and 143 age-matched controls.
|
19380025 |
2009 |
|
rs11536898
|
|
Rectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
TLR3 rs11721827 was associated with rectal cancer (odds ratio [OR] 1.27, 95% confidence interval [CI] 1.02, 1.58 for AC/CC vs. AA genotype, Wald p = 0.035; adjusted p = 0.126); TLR3 rs3775292 and TLR4 rs11536898 were associated with colon cancer (OR 0.68, 95% CI 0.49, 0.95 for GG vs. CC/CG and OR 0.50.
|
21792899 |
2012 |
|
rs11536898
|
|
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
TLR3 rs11721827 was associated with rectal cancer (odds ratio [OR] 1.27, 95% confidence interval [CI] 1.02, 1.58 for AC/CC vs. AA genotype, Wald p = 0.035; adjusted p = 0.126); TLR3 rs3775292 and TLR4 rs11536898 were associated with colon cancer (OR 0.68, 95% CI 0.49, 0.95 for GG vs. CC/CG and OR 0.50.
|
21792899 |
2012 |
|
rs11536898
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
TLR3 rs11721827 was associated with rectal cancer (odds ratio [OR] 1.27, 95% confidence interval [CI] 1.02, 1.58 for AC/CC vs. AA genotype, Wald p = 0.035; adjusted p = 0.126); TLR3 rs3775292 and TLR4 rs11536898 were associated with colon cancer (OR 0.68, 95% CI 0.49, 0.95 for GG vs. CC/CG and OR 0.50.
|
21792899 |
2012 |