|
rs9350271
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.700 |
GeneticVariation
|
GWASDB |
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.
|
17460697 |
2007 |
|
rs7752906
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.700 |
GeneticVariation
|
GWASDB |
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.
|
17460697 |
2007 |
|
rs1569699
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.700 |
GeneticVariation
|
GWASDB |
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.
|
17460697 |
2007 |
|
rs10946398
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
|
19056611 |
2009 |
|
rs10946398
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASDB |
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
|
19056611 |
2009 |
|
rs7754840
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
After correcting for multiple testing, however, only the association between T2D and rs7754840 at CDKAL1 (P < 1×10(-4)) remains significant.
|
21643948 |
2012 |
|
rs7756992
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
All the five SNPs were significantly associated with T2D risk with overall effects (odds ratio, OR) from 1.19 to 1.29 in the additive genetic model (rs6931514: OR=1.29, 95% confidence intervals (95% CI)=1.19-1.39, P=5.6 × 10(-10); rs7756992: OR=1.23, 95% CI=1.15-1.32, P=1.2 × 10(-8); rs4712523: OR=1.25, 95% CI=1.15-1.35, P=3.8 × 10(-8); rs4712524: OR=1.24, 95% CI=1.15-1.35, P=6.8 × 10(-8); rs9472138: OR=1.19, 95% CI=1.05-1.34, P=006).
|
22437209 |
2012 |
|
rs4712523
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
BEFREE |
All the five SNPs were significantly associated with T2D risk with overall effects (odds ratio, OR) from 1.19 to 1.29 in the additive genetic model (rs6931514: OR=1.29, 95% confidence intervals (95% CI)=1.19-1.39, P=5.6 × 10(-10); rs7756992: OR=1.23, 95% CI=1.15-1.32, P=1.2 × 10(-8); rs4712523: OR=1.25, 95% CI=1.15-1.35, P=3.8 × 10(-8); rs4712524: OR=1.24, 95% CI=1.15-1.35, P=6.8 × 10(-8); rs9472138: OR=1.19, 95% CI=1.05-1.34, P=006).
|
22437209 |
2012 |
|
rs4712524
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.820 |
GeneticVariation
|
BEFREE |
All the five SNPs were significantly associated with T2D risk with overall effects (odds ratio, OR) from 1.19 to 1.29 in the additive genetic model (rs6931514: OR=1.29, 95% confidence intervals (95% CI)=1.19-1.39, P=5.6 × 10(-10); rs7756992: OR=1.23, 95% CI=1.15-1.32, P=1.2 × 10(-8); rs4712523: OR=1.25, 95% CI=1.15-1.35, P=3.8 × 10(-8); rs4712524: OR=1.24, 95% CI=1.15-1.35, P=6.8 × 10(-8); rs9472138: OR=1.19, 95% CI=1.05-1.34, P=006).
|
22437209 |
2012 |
|
rs7756992
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Among the 11 loci examined, 6 were significantly associated with type 2 diabetes in our population by a logistic regression analysis, similar to previously reported results (rs4402960, P = 0.00009; rs10811661, P = 0.0024; rs5219, P = 0.0034; rs1111875, P = 0.0064; rs13266634, P = 0.0073; rs7756992, P = 0.0363).
|
18162508 |
2008 |
|
rs7756992
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Associations with type 2 diabetes mellitus have been identified for variants CDKAL1 rs7756992, KCNJ11 rs5219, and IGF2BP2 rs4402960 in different populations.
|
24898818 |
2014 |
|
rs7756992
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Birthweight was inversely associated with the type 2 diabetes risk alleles of ADCY5 rs11708067 (beta = -33 g [95% CI -55, -10], p = 0.004) and CDKAL1 rs7756992 (beta = -22 g [95% CI -43, -1], p = 0.04).
|
20490451 |
2010 |
|
rs7756992
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes.
|
28821857 |
2017 |
|
rs35612982
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.710 |
GeneticVariation
|
BEFREE |
CDKAL1 rs35612982 (C/T) polymorphism, as a new polymorphism, was associated with the increased risk of T2D in the Han Chinese population.
|
31639799 |
2019 |
|
rs6931514
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.820 |
GeneticVariation
|
BEFREE |
Compared with the wild homozygote of rs6931514 and rs9472138, subjects with variant alleles of the two SNPs had increased risk for T2D susceptibility in a dose-response manner (P(trend)=7.4 × 10(-12)).
|
22437209 |
2012 |
|
rs4712523
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
G |
0.830 |
GeneticVariation
|
GWASCAT |
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
|
19401414 |
2009 |
|
rs4712523
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
G |
0.830 |
GeneticVariation
|
GWASDB |
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
|
19401414 |
2009 |
|
rs10946398
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Cyclin- dependent kinase 5 (CDK5) regulatory subunit-associated protein 1-like 1 (CDKAL1) rs10946398, a novel body mass index (BMI)-associated locus specifically in the Asian population, may impair insulin secretion and may be associated with insulin resistance and type 2 diabetes.
|
26119585 |
2015 |
|
rs9460550
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
A |
0.800 |
GeneticVariation
|
GWASCAT |
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
|
31118516 |
2019 |
|
rs10946398
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Five risk variants in IGF2BP2 (rs4402960, rs1470579), CDKAL1 (rs10946398), SLC30A8 (rs13266634), and HHEX (rs1111875) genes were nominally associated with T2DM in our samples.
|
24736664 |
2014 |
|
rs7756992
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Further analysis revealed that the sequence variant (rs5015480) near HHEX and two SNPs (rs7756992 and rs9465871) in CDKAL1 were associated with the susceptibility of T2DM in females (P<0.005), but not in males (P>0.005).
|
21368910 |
2011 |
|
rs9465871
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
BEFREE |
Further analysis revealed that the sequence variant (rs5015480) near HHEX and two SNPs (rs7756992 and rs9465871) in CDKAL1 were associated with the susceptibility of T2DM in females (P<0.005), but not in males (P>0.005).
|
21368910 |
2011 |
|
rs7754840
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Furthermore, rs7754840 was associated with type 2 diabetes in Finnish men (study 2).
|
18285412 |
2008 |
|
rs4712523
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
G |
0.830 |
GeneticVariation
|
GWASCAT |
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
|
19734900 |
2009 |
|
rs10946398
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genetic variants in CDKN2A/B, CDKAL1, TCF7L2, TCF2, MC4R, and PPARG showed a nominal association with type 2 diabetes (P<or=0.05), of whom the three first would stand correction for multiple testing: CDKN2A/B rs10811661, OR: 1.26 (1.12-1.43) P = 1.8*10(-4); CDKAL1 rs10946398, OR: 1.23 (1.09-1.39); P = 7.1*10(-4), and TCF7L2 rs7903146, OR: 1.61 (1.19-2.18) P = 2.3 * 10(-3).
|
20161779 |
2010 |