|
rs1800795
|
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
We genotyped rs1800795 in overweight/obese women (<i>N</i> = 242) who were randomly assigned to a lower fat (20% energy), higher carbohydrate (65% energy) diet; a lower carbohydrate (45% energy), higher fat (35% energy) diet; or a walnut-rich (18% energy), higher fat (35% energy), lower carbohydrate (45% energy) diet in a 1-year weight loss intervention study of obesity-related biomarkers for breast cancer incidence and mortality.
|
28555011 |
2017 |
|
rs1800795
|
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
We genotyped rs1800795 in overweight/obese women (<i>N</i> = 242) who were randomly assigned to a lower fat (20% energy), higher carbohydrate (65% energy) diet; a lower carbohydrate (45% energy), higher fat (35% energy) diet; or a walnut-rich (18% energy), higher fat (35% energy), lower carbohydrate (45% energy) diet in a 1-year weight loss intervention study of obesity-related biomarkers for breast cancer incidence and mortality.
|
28555011 |
2017 |
|
rs1800795
|
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
These findings suggest that GG SNP at IL-6: rs1800795 may indicate an increased risk of metastasis of primary breast cancer.
|
28732081 |
2017 |
|
rs1800795
|
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
These findings suggest that GG SNP at IL-6: rs1800795 may indicate an increased risk of metastasis of primary breast cancer.
|
28732081 |
2017 |
|
rs1800795
|
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
RESULTS The present meta-analysis found that rs1800795 SNP of IL-6 gene is not significantly associated with susceptibility to arterial thromboembolic events (C allele vs. G allele, OR=1.04, 95% CI=0.91-1.19, P=0.619; CC vs. CG+GG, OR=1.09, 95% CI=0.91-1.31, P=0.364; CC+CG vs. GG, OR=0.97, 95% CI=0.78-1.21, P=0.763, respectively), and the SNP of IL-6 gene also did not show any significant association with ischemic stroke or myocardial infarction (P>0.05 in each model).
|
27840402 |
2016 |
|
rs1800795
|
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our study investigated the frequency of interleukin-6 (IL-6) promoter polymorphism rs1800795 (-174 G>C), possible association of this polymorphism with IL-6 levels and the outcome after stroke in 95 patients with acute ischemic stroke and 268 healthy subjects.
|
27049557 |
2016 |
|
rs1800795
|
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
The objective of this study was to evaluate the relationship between three polymorphisms; including tumour necrosis alpha (TNFα)-238 GA, interleukin( IL-10)-1028 GA (rs1800896), IL-6-(rs1800795) and ischemic stroke in a Turkish population.
|
26722564 |
2015 |
|
rs1800795
|
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
Mutant allele and genotype at IL-1β [+3954 C>T (rs1143634)] site associated with increased BC risk, while mutant allele and genotypes at IL-6 [-174 G>C (rs1800795)] polymorphism appeared to be protective.
|
22818022 |
2012 |
|
rs1800795
|
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Mutant allele and genotype at IL-1β [+3954 C>T (rs1143634)] site associated with increased BC risk, while mutant allele and genotypes at IL-6 [-174 G>C (rs1800795)] polymorphism appeared to be protective.
|
22818022 |
2012 |
|
rs1800795
|
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
The association between single-nucleotide polymorphisms -174G/C (rs1800795) and -572G/C (rs1800796) in the interleukin-6 (IL-6) gene promoter region and ischemic heart disease (IHD)/ischemic stroke (IS) remains controversial and ambiguous.
|
21536090 |
2011 |
|
rs1800795
|
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
We have previously observed that genetic profiles determined by the combination of five functionally significant single nucleotide polymorphisms (SNPs) (rs1800795, rs5498, rs5361, rs1024611, and rs679620) of genes encoding prototypical inflammatory molecules are associated with history of ischemic stroke.
|
20622166 |
2010 |
|
rs1800795
|
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
The association between a single-nucleotide polymorphism (SNP) -174G > C (rs1800795) located in the IL-6 gene promoter and breast cancer risk is still controversial and ambiguous.
|
20043205 |
2010 |
|
rs1800795
|
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
The association between a single-nucleotide polymorphism (SNP) -174G > C (rs1800795) located in the IL-6 gene promoter and breast cancer risk is still controversial and ambiguous.
|
20043205 |
2010 |
|
rs1800795
|
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Among women without recent hormone exposure, those with a WHR >0.9 and the rs1800795 GG genotype had a greater than threefold increased risk of bre</span>ast cancer (odds ratios (ORs) 3.22, 95% confidence intervals (CIs) 1.27, 817) when compared with women with a WHR <0.8 and the rs1800795 GG genotype (P interaction 0.01).
|
18239642 |
2008 |
|
rs1800795
|
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
Among women without recent hormone exposure, those with a WHR >0.9 and the rs1800795 GG genotype had a greater than threefold increased risk of bre</span>ast cancer (odds ratios (ORs) 3.22, 95% confidence intervals (CIs) 1.27, 817) when compared with women with a WHR <0.8 and the rs1800795 GG genotype (P interaction 0.01).
|
18239642 |
2008 |
|
rs1800795
|
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
Among postmenopausal women not recently exposed to hormones, the AG/GG genotypes of rs1800797 (-596A>G) and the GC/CC genotypes of rs1800795 (-174G>C) significantly reduced risk of breast cancer among non-Hispanic white women [odds ratio (OR), 0.69; 95% confidence interval (95% CI), 0.48-1.00 and OR, 0.68; 95% CI, 0.47-0.99, respectively] and Hispanic/Native American women (OR, 0.48; 95% CI, 0.28-0.83 and OR, 0.44; 95% CI, 0.26-0.99, respectively).
|
17416766 |
2007 |
|
rs1800795
|
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Among postmenopausal women not recently exposed to hormones, the AG/GG genotypes of rs1800797 (-596A>G) and the GC/CC genotypes of rs1800795 (-174G>C) significantly reduced risk of breast cancer among non-Hispanic white women [odds ratio (OR), 0.69; 95% confidence interval (95% CI), 0.48-1.00 and OR, 0.68; 95% CI, 0.47-0.99, respectively] and Hispanic/Native American women (OR, 0.48; 95% CI, 0.28-0.83 and OR, 0.44; 95% CI, 0.26-0.99, respectively).
|
17416766 |
2007 |
|
rs1800795
|
|
Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
There were no significant relationships between rs1800795 status and any patient or tumor characteristics, including estrogen receptor status.
|
28732081 |
2017 |
|
rs1800795
|
|
Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
The rs1800795 polymorphism in the promoter of the gene IL-6 can affect the transcription and expression of the gene, becoming a common target in association studies on tumors.
|
28296724 |
2017 |
|
rs1800795
|
|
Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
Associations between potentially functional IL6 (rs2069837 and rs1800795) and STAT3 (rs744166 and rs4796793) SNPs and clinical outcomes [progression-free survival (PFS), overall survival, and tumor response rate] were evaluated in mCRC patients receiving first-line FOLFIRI plus bevacizumab in two randomized phase III trials: TRIBE (n = 223, training cohort) and FIRE-3 (n = 288, validation cohort).
|
26839145 |
2016 |
|
rs1800795
|
|
Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
Most associations varied by recent aspirin/NSAID use: IL6 rs1800796 and rs1800795 polymorphisms were associated inversely with tumor mutations in the presence of aspirin/NSAIDs; POMC significantly reduced risk of Ki-ras-mutated tumors when aspirin/NSAIDs were not used; the TCF7L2 rs7903146 was associated with reduced risk of Ki-ras-mutated tumors in the presence of aspirin and increased risk in the absence of aspirin.
|
18992263 |
2009 |
|
rs1800795
|
|
Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
We assessed how these tumor markers were associated with use of anti-inflammatory drugs, polymorphisms in the IL6 genes (rs1800795 and rs1800796) and dietary antioxidants.
|
19452524 |
2009 |
|
rs1800795
|
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that IL-6 rs1800795, IL-18 rs1946518 and IL-18 rs187238 polymorphisms may confer susceptibility to TB, especially for Asians.
|
31676365 |
2020 |
|
rs1800795
|
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that IL-2 rs2069762, IL-4 rs2243250, IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871 and IL-10 rs1800896 polymorphisms may confer susceptibility to TB, especially for Asians.
|
31669382 |
2020 |
|
rs1800795
|
|
Coronary Artery Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Additionally, we found that carriers of the <i>C</i> allele of 174<i>G>C</i> (rs1800795) polymorphism have an increase in the risk of coronary artery disease under the hereditary models assessed in the study.
|
31338006 |
2019 |