|
rs1567176006
|
|
Glioblastoma Multiforme
|
G |
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
|
rs17855787
|
|
Glioblastoma Multiforme
|
|
0.700 |
GeneticVariation
|
UNIPROT |
|
|
|
|
rs2235573
|
|
Glioblastoma Multiforme
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10<sup>-9</sup>, odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10<sup>-10</sup>, OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10<sup>-8</sup>, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10<sup>-11</sup>, OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10<sup>-10</sup>, OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10<sup>-9</sup>, OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10<sup>-10</sup>, OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10<sup>-10</sup>, OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10<sup>-9</sup>, OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10<sup>-8</sup>, OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10<sup>-10</sup>, OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10<sup>-11</sup>, OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10<sup>-9</sup>, OR = 1.18).
|
28346443 |
2017 |
|
rs2562152
|
|
Glioblastoma Multiforme
|
T |
0.700 |
GeneticVariation
|
GWASCAT |
We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10<sup>-9</sup>, odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10<sup>-10</sup>, OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10<sup>-8</sup>, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10<sup>-11</sup>, OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10<sup>-10</sup>, OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10<sup>-9</sup>, OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10<sup>-10</sup>, OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10<sup>-10</sup>, OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10<sup>-9</sup>, OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10<sup>-8</sup>, OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10<sup>-10</sup>, OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10<sup>-11</sup>, OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10<sup>-9</sup>, OR = 1.18).
|
28346443 |
2017 |
|
rs35850753
|
|
Glioblastoma Multiforme
|
T |
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for glioma.
|
26424050 |
2015 |
|
rs371854396
|
|
Glioblastoma Multiforme
|
|
0.700 |
GeneticVariation
|
UNIPROT |
|
|
|
|
rs375412266
|
|
Glioblastoma Multiforme
|
|
0.700 |
GeneticVariation
|
UNIPROT |
|
|
|
|
rs59060240
|
|
Glioblastoma Multiforme
|
T |
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for glioma.
|
26424050 |
2015 |
|
rs6062302
|
|
Glioblastoma Multiforme
|
C |
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for glioma.
|
26424050 |
2015 |
|
rs634537
|
|
Glioblastoma Multiforme
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.
|
30152087 |
2018 |
|
rs634537
|
|
Glioblastoma Multiforme
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
|
rs723527
|
|
Glioblastoma Multiforme
|
A |
0.700 |
GeneticVariation
|
GWASCAT |
Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.
|
30152087 |
2018 |
|
rs723527
|
|
Glioblastoma Multiforme
|
A |
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
|
rs72709458
|
|
Glioblastoma Multiforme
|
T |
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for glioma.
|
26424050 |
2015 |
|
rs75061358
|
|
Glioblastoma Multiforme
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.
|
30152087 |
2018 |
|
rs75061358
|
|
Glioblastoma Multiforme
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
|
rs75061358
|
|
Glioblastoma Multiforme
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for glioma.
|
26424050 |
2015 |
|
rs757496714
|
|
Glioblastoma Multiforme
|
|
0.700 |
GeneticVariation
|
UNIPROT |
|
|
|
|
rs770462360
|
|
Glioblastoma Multiforme
|
|
0.700 |
GeneticVariation
|
UNIPROT |
|
|
|
|
rs7732320
|
|
Glioblastoma Multiforme
|
T |
0.700 |
GeneticVariation
|
GWASCAT |
SSBP2 variants are associated with survival in glioblastoma patients.
|
22472174 |
2012 |
|
rs779221554
|
|
Glioblastoma Multiforme
|
|
0.700 |
GeneticVariation
|
UNIPROT |
|
|
|
|
rs121913500
|
|
Glioblastoma Multiforme
|
|
0.100 |
GeneticVariation
|
BEFREE |
For this reason, it was suggested that immunohistochemistry against IDH1 R132H is sufficient to classify GBM as IDH wild-type in this age group.
|
31758617 |
2020 |
|
rs121913500
|
|
Glioblastoma Multiforme
|
|
0.100 |
GeneticVariation
|
BEFREE |
Tumor-to-muscle ratios were also significantly higher in U251/IDH1 R132H tumo</span>rs (3.36 ± </span>0.41 vs. 1.88 ± 0.59, p = 0.0030).
|
31667733 |
2019 |
|
rs121913500
|
|
Glioblastoma Multiforme
|
|
0.100 |
GeneticVariation
|
BEFREE |
The R132H mutation in isocitrate dehydrogenase 1 (IDH1<sup>R132H</sup>) is commonly observed and associated with better survival in glioblastoma multiforme (GBM), a malignant brain tumor.
|
31151327 |
2019 |
|
rs121913500
|
|
Glioblastoma Multiforme
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found that both low-grade and high-grade (i.e., GBM) IDH1 R132H gliomas exhibit low Fn14 mRNA and protein levels compared to IDH1 WT gliomas.
|
29453678 |
2018 |