rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The interleukin 28B rs12979860 C/T polymorphism and serum cholesterol as predictors of fibrosis progression in patients with chronic hepatitis C and persistently normal transaminases.
|
22431022 |
2012 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The IL28B rs12979860 polymorphism correlates with the biochemical activity and the presence and severity of liver steatosis in chronic hepatitis C.
|
22666430 |
2012 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
To evaluate the effect of single nucleotide polymorphisms of interleukin (IL)-28B, rs12979860 on progression and treatment response in chronic hepatitis C.
|
23002361 |
2012 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Patients requiring liver transplantation due to end-stage chronic hepatitis C appeared to be selected toward the adverse genotypes rs12979860 CT/TT compared to non-transplanted HCV-infected patients (p=0.046).
|
21147186 |
2011 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
We previously found that LDL cholesterol levels were higher in chronic hepatitis C (CHC) patients with the CC genotype at the rs12979860 polymorphism, located proximal to the IL28 gene.
|
21703198 |
2011 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The IL28B genotype is the most important pretreatment predictor of treatment outcome in patients with chronic hepatitis C. The impact of the rs12979860 genotype on relapse was retrospectively evaluated in genotype 1/4 patients who received response-guided therapy with peginterferon alpha-2a 180 μg/week plus ribavirin 1,000/1,200 mg/day in a large, randomized, multicenter study.
|
22006276 |
2011 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
41 patients with genotype 1 chronic hepatitis C infection from the Duke Liver Clinic were genotyped for rs12979860.
|
21750736 |
2011 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped chronic hepatitis C (CHC) genotype 1 patients with PegIFN/R treatment-induced clearance (n = 417) and treatment failure (n = 493), and 234 individuals with spontaneous clearance, for HLA-C C1 versus C2, presence of inhibitory and activating KIR genes, and two IL28B SNPs, rs8099917 and rs12979860.
|
21931540 |
2011 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Vitamin D serum levels are complementary to the IL-28B rs12979860 C/T polymorphism in enhancing the correct prediction of the SVR in treatment-naïve chronic hepatitis C.
|
21480318 |
2011 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Role of interleukin 28B rs12979860 C/T polymorphism on the histological outcome of chronic hepatitis C: relationship with gender and viral genotype.
|
21647799 |
2011 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
These results demonstrate that the genotypes rs12979860 CC and rs8099917 TT were more frequently observed in Korean patients compared to other ethnicities, and suggest that the genetic characteristics of patients may be prognostic factor that predicts antiviral response to PEG-IFN therapy for chronic hepatitis C.
|
21907615 |
2011 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism (SNP) near the IL28B gene (rs12979860) strongly predicts sustained virological response to pegylated interferon plus ribavirin (pegIFN-RBV) treatment for chronic hepatitis C virus (HCV) infection.
|
20964522 |
2010 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs12979860 SNP located near the IL28B gene is associated with HCV treatment response in HIV-infected patients with chronic hepatitis C due to genotypes 1 or 4.
|
20389235 |
2010 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
With the screening for IL28B polymorphisms rs12980275, rs8099917 and rs12979860, which are associated with HCV chronicity and with reduced SVR rates, an important prognostic factor of the therapy of chronic hepatitis C can be easily diagnosed.
|
21149916 |
2010 |