|
rs16892766
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |
|
rs16892766
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|
19011631 |
2008 |
|
rs16892766
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
An association between SNP rs3802842 on chromosome 11q23.1 and rs16892766 on chromosome 8q23.3 and the risk of developing CRC and age of diagnosis was found in MLH1 mutation carriers.
|
21097774 |
2011 |
|
rs16892766
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Collectively, our analysis further supports previous findings that the rs16892766</span> polymorphism is significantly associated with CRC susceptibility.
|
25609216 |
2015 |
|
rs16892766
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 x 10(-13) overall; P = 6.9 x 10(-12) replication), and rs16892766, at 8q23.3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H.
|
18372905 |
2008 |
|
rs16892766
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings demonstrated that rs16892766-C allele might be risk-conferring factors for the development of CRC, but not for CRA.
|
25293934 |
2015 |
|
rs16892766
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Pooled sample-based GWAS: a cost-effective alternative for identifying colorectal and prostate cancer risk variants in the Polish population.
|
22532847 |
2012 |
|
rs16892766
|
|
Colorectal Carcinoma
|
C |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
|
26151821 |
2015 |
|
rs16892766
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to perform an association study between risk variants: rs10795668, rs16892766, rs3802842 and rs4939827 and CRC risk in Croatian population.
|
24066093 |
2013 |
|
rs16892766
|
|
Colorectal Carcinoma
|
C |
0.900 |
GeneticVariation
|
GWASCAT |
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
|
29917119 |
2019 |
|
rs16892766
|
|
Colorectal Carcinoma
|
C |
0.900 |
GeneticVariation
|
GWASCAT |
Discovery of common and rare genetic risk variants for colorectal cancer.
|
30510241 |
2019 |
|
rs16892766
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Overall, the association of most CRC susceptibility loci identified in initial GWAS seems to be invariant to the other risk factors considered; however, our results suggest potential modification of the rs16892766 effect by vegetable consumption.
|
22367214 |
2012 |
|
rs16892766
|
|
Colorectal Carcinoma
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 x 10(-13) overall; P = 6.9 x 10(-12) replication), and rs16892766, at 8q23.3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H.
|
18372905 |
2008 |
|
rs4779584
|
|
Colorectal Carcinoma
|
|
0.870 |
GeneticVariation
|
BEFREE |
We used meta-analysis of an efficient empirical-Bayes estimator to detect potential multiplicative interactions between each of the SNPs [rs16892766 at 8q23.3 (EIF3H/UTP23), rs6983267 at 8q24 (MYC), rs10795668 at 10p14 (FLJ3802842), rs3802842 at 11q23 (LOC120376), rs4444235 at 14q22.2 (BMP4), rs4779584 at 15q13 (GREM1), rs9929218 at 16q22.1 (CDH1), rs4939827 at 18q21 (SMAD7), rs10411210 at 19q13.1 (RHPN2), and rs961253 at 20p12.3 (BMP2)] and select major CRC risk factors (sex, body mass index, height, smoking status, aspirin/nonsteroidal anti-inflammatory drug use, alcohol use, and dietary intake of calcium, folate, red meat, processed meat, vegetables, fruit, and fiber).
|
22367214 |
2012 |
|
rs4779584
|
|
Colorectal Carcinoma
|
|
0.870 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrated that the rs4779584 and rs10318 polymorphism at 15q13.3 is a risk factor associated with increased CRC/CRA susceptibility, but these associations vary in different ethnic populations.
|
25475391 |
2015 |
|
rs4779584
|
|
Colorectal Carcinoma
|
|
0.870 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
|
18372905 |
2008 |
|
rs4779584
|
|
Colorectal Carcinoma
|
|
0.870 |
GeneticVariation
|
GWASCAT |
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
21761138 |
2012 |
|
rs4779584
|
|
Colorectal Carcinoma
|
|
0.870 |
GeneticVariation
|
BEFREE |
GREM1-SCG5 rs4779584 polymorphisms may increase the risk of developing colorectal cancer.
|
24586997 |
2014 |
|
rs4779584
|
|
Colorectal Carcinoma
|
T |
0.870 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
|
26151821 |
2015 |
|
rs4779584
|
|
Colorectal Carcinoma
|
|
0.870 |
GeneticVariation
|
BEFREE |
We confirmed the association of CRC risk with four SNPs, with odds ratio (OR) higher than previously reported: rs16892766 on 8q23.3 (OR: 1.88, 95% confidence interval (CI): 1.30-2.72; P=0.0007); rs4779584 on 15q13.3 (OR: 1.42, CI: 1.11-1.83; P=0.0061) and rs4939827 and rs58920878/Novel 1 on 18q21.1 (OR: 1.49, CI: 1.13-1.98; P=0.007 and OR: 1.49, CI: 1.14-1.95; P=0.0035).
|
25873010 |
2016 |
|
rs4779584
|
|
Colorectal Carcinoma
|
|
0.870 |
GeneticVariation
|
BEFREE |
In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)).
|
18084292 |
2008 |
|
rs4779584
|
|
Colorectal Carcinoma
|
|
0.870 |
GeneticVariation
|
BEFREE |
Near GREM1, we found using fine-mapping that the previously-identified association between tagSNP rs4779584 and CRC actually resulted from two independent signals represented by rs16969681 (P = 5.33×10(-8)) and rs11632715 (P = 2.30×10(-10)).
|
21655089 |
2011 |
|
rs4779584
|
|
Colorectal Carcinoma
|
|
0.870 |
GeneticVariation
|
GWASDB |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |
|
rs4779584
|
|
Colorectal Carcinoma
|
|
0.870 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
|
18372905 |
2008 |
|
rs4779584
|
|
Colorectal Carcinoma
|
|
0.870 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|
19011631 |
2008 |