DisGeNET - a database of gene-disease associations

Source: GWASCAT

Disease: Bilirubin measurement ×

Gene: UGT1A3 ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs4148325

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

We analyzed total bilirubin levels, which are linked to fatty liver in severe obesity, and observed the strongest evidence for association with rs4148325 in UGT1A (P < 5.0 × 10(-93)), replicating previous findings.

25246029

2015

dbSNP:

rs4148325

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Genomewide association study of tenofovir pharmacokinetics and creatinine clearance in AIDS Clinical Trials Group protocol A5202.

26148204

2015

dbSNP:

rs4148325

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.

21646302

2011

dbSNP:

rs4663969

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols.

25884002

2015

dbSNP:

rs6431630

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

29403010

2018

dbSNP:

rs6714634

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3 ; LOC100286922

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Genomewide association study of tenofovir pharmacokinetics and creatinine clearance in AIDS Clinical Trials Group protocol A5202.

26148204

2015

dbSNP:

rs6742078

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Genomewide association study of tenofovir pharmacokinetics and creatinine clearance in AIDS Clinical Trials Group protocol A5202.

26148204

2015

dbSNP:

rs6742078

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.

23371916

2013

dbSNP:

rs6742078

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Genome-wide association of serum bilirubin levels in Korean population.

20639394

2010

dbSNP:

rs6742078

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs7564935

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.

31675503

2019

dbSNP:

rs7604115

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Genomewide association study of tenofovir pharmacokinetics and creatinine clearance in AIDS Clinical Trials Group protocol A5202.

26148204

2015

dbSNP:

rs8330

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3 ; MROH2A

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

29403010

2018

dbSNP:

rs887829

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Genomewide association study of tenofovir pharmacokinetics and creatinine clearance in AIDS Clinical Trials Group protocol A5202.

26148204

2015

dbSNP:

rs887829

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols.

25884002

2015

dbSNP:

rs887829

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.

23642732

2013

dbSNP:

rs887829

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.

22558097

2012

dbSNP:

rs887829

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Taking advantage of the lower LD and shorter haplotypes in African-ancestry populations, we identified rs887829 as a more refined proxy for the causative variant influencing bilirubin levels.

22085899

2012

dbSNP:

rs887829

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.

19419973

2009

dbSNP:

rs929596

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population.

30621171

2019

dbSNP:

rs929596

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Genomewide association study of tenofovir pharmacokinetics and creatinine clearance in AIDS Clinical Trials Group protocol A5202.

26148204

2015

dbSNP:

rs929596

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols.

25884002

2015