rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I/D gene polymorphism of the angiotensin-converting enzyme and M235T of angiotensinogen were ruled out as risk factors for hypertension.
|
23598646 |
2013 |
rs1267969615
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
We determined the association of angiotensinogen (M235T) gene polymorphism with essential hypertension and the relationship between polymorphism in the angiotensinogen (M235T) gene and blood pressure response to ACE inhibitor (Enalapril) in patients with essential hypertension from northern Indian subjects.
|
22974788 |
2012 |
rs1267969615
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied the effects of the angiotensinogen M235T, angiotensin converting enzyme insertion/deletion (ACE I/D), and angiotensin II receptor 1 (AT1R) A1166C gene polymorphisms on the risk of HTA and to evaluate the relationship between these polymorphisms and obesity.
|
21779803 |
2012 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Renin-angiotensin-aldosterone system (RAAS) polymorphisms such as the angiotensinogen-gene-M235T-, the angiotensin-conversion enzyme (ACE)-gene I/D- and the angiotensin-II-type 1-receptor-(AT1R)-A1166C-polymorphism have been implicated in renal insufficiency and hypertension.
|
19681973 |
2010 |
rs1267969615
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present meta-analysis suggests that AGT M235T and ACE I/D modulate the risk of essential hypertension in Han Chinese population.
|
20087216 |
2010 |
rs1267969615
|
|
Diabetic Nephropathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the gender differences in the effect of ACE I/D and AGT M235T polymorphisms on the prognosis of diabetic nephropathy (DN).
|
18849600 |
2009 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension, an important risk factor for the development and progression of diabetic nephropathy.
|
18413162 |
2008 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We also screened angiotensinogen gene AGT M235T and angiotensin-converting enzyme insertion/deletion polymorphism ACE I/D and found an association between TT genotype and hypertension.
|
18758497 |
2008 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied the effects of the angiotensinogen T174M and M235T, angiotensin converting enzyme insertion/deletion (ACE I/D), and angiotensin II receptor 1 (AT1R) A1166C gene polymorphisms on the risk of hypertension among Hispanics.
|
18497458 |
2008 |
rs1267969615
|
|
Diabetic Nephropathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the relationship of the ACE insertion/deletion (I/D) and AGT M235T</span> gene polymorphisms in Turkish patients with type 2 diabetes mellitus (DM) with and without diabetic nephropathy.
|
18413162 |
2008 |
rs1267969615
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although polymorphisms in renin-angiotensin-aldosterone (RAA) system genes for angiotensinogen (AGT M235T), angiotensin-converting enzyme (ACE I/D), angiotensin II type 1 receptor (AT1 A/C1166), and aldosterone synthase (CYP11B2-344T/C) have been major targets for genetic investigation in association with essential hypertension (EH), the influence of these genetic factors is still to be determined.
|
17190732 |
2007 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
M235T polymorphism of the angiotensinogen gene and insertion/deletion polymorphism of the angiotensin-1 converting enzyme gene in essential arterial hypertension in Caucasians.
|
17448297 |
2007 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In Slovak population, M235T is associated with increased blood pressure and D allele of ACE gene is associated with MI, chronic CHD and DCM, rather than with hypertension.
|
17579251 |
2007 |
rs1267969615
|
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
A significant drug-gene interaction was not found on the risk of stroke (SI: 1.83; 95% CI: 0.95-3.54) in ACE-inhibitor users or between current use of beta-blockers and the AGT M235T polymorphism on the risk of MI or stroke.
|
17299437 |
2007 |
rs1267969615
|
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
In Slovak population, M235T is associated with increased blood pressure and D allele of ACE gene is associated with MI, chronic CHD and DCM, rather than with hypertension.
|
17579251 |
2007 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
People who carried both ACE ID (or DD) and AGT M235T MT (or MM) had more risk to have hypertension.
|
16685579 |
2006 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A case-control association study was conducted to investigate a possible involvement of polymorphisms of three renin-angiotensin system genes: ACE (I/D and T-3892C), AGT (M235T and T174M), and AT1R (A1166C) in the early development of hypertension.
|
16876684 |
2006 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, no association was found between M235T polymorphism and insulin resistance or PAI-1 levels, but results indicate relationship between I/D polymorphism of the ACE gene and plasma PAI-1 levels in the early stage of hypertension.
|
16981142 |
2006 |
rs1267969615
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated if renin-angiotensinaldosterone system associated genotypes (angiotensinogen [M235T] and ACE [I/D]) are related to blood pressure (BP), renal haemodynamics and sodium excretion in sex and age-matched (1835 years) healthy Caucasian offspring of either two parents with EH (n=101, EH-offspring) or two normotensive parents (n=50, controls).
|
17083073 |
2006 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ACE I/D polymorphism does not contribute to the presence and severity of essential hypertension, while the AGT M235T TT genotype confers a significantly decreased risk for the development of hypertension in the population studied here.
|
15642127 |
2005 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Haplotype frequencies for M235T and G-6A were significantly different between hypertensive individuals and controls, which indicated an association of angiotensinogen gene haplotypes with hypertension, and a significant association of 235T/-6A haplotype with hypotensive effect.
|
15386947 |
2004 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
One DNA polymorphism within exon 2- with threonine instead of methionine at position 235 (M235T) was found to be significantly associated with hypertension.
|
12169209 |
2003 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
M235T and T174M variants do not contribute to the increased risk of CHD or hypertension in the Indian population.
|
12938141 |
2003 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ACE-I/D polymorphism was shown to be a risk factor of progression of renal disease and the AGT-M235T polymorphism was associated with the severity of arterial hypertension.
|
14610337 |
2003 |
rs1267969615
|
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TT genotype of the AGT gene M235T polymorphism was associated with an increased risk of CHD and myocardial infarction only in smokers.
|
14502296 |
2003 |