|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The ARMS2/HTRA1 genes at the 10q26 locus have been associated with risk of age-related macular degeneration (AMD), with the most significantly associated variants being A69S (rs10490924), del443ins54 (EU427539) and rs11200638.
|
23592919 |
2013 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The association of SKIV2L rs429608 with neovascular AMD remained significant after adjusting for CFH rs800292 and HTRA1 rs11200638.
|
23260260 |
2013 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The findings indicate that the intergenic region between the tSNP rs3793917 and the SNP rs11200638 in the HTRA1 gene is the most likely site explaining the significant association with AMD.
|
20445115 |
2010 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The genotypes were compared using chi square analysis for an additive allelic model. rs11200638 was significantly associated with wet AMD (p=5.00x10(-12)).
|
17904186 |
2007 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The haplotypes constructed of rs3793784-rs11200638 were found to be associated with AMD development, as well.
|
31583032 |
2019 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The HTRA1 promoter polymorphism, rs11200638, is a strong candidate with a functional consequence that predisposes Japanese to develop neovascular AMD.
|
17438519 |
2007 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The HTRA1 promoter SNP (rs11200638) and A69S at LOC387715/ARMS2 were associated with a poorer visual outcome for ranibizumab or bevacizumab treatment in neovascular AMD, suggesting strong pharmacogenetic associations with anti-VEGF treatment.
|
23582991 |
2013 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The ORs of exudative AMD for individuals carrying one copy risk allele and two copy risk alleles were 2.57 (1.21 - 5.45) and 4.76 (2.15 - 10.55) respectively, with correspondent PARs of 28.3% (2.0% - 40.5%) and 38.2% (21.8% - 45.4%). rs11200638 in HTRA1 was another susceptible locus for AMD and the risk homozygotes were significantly susceptible for exudutive AMD (OR = 3.98, 1.88 - 8.43) with PAR of 38.9% (24.3% - 45.8%).
|
19187590 |
2008 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
There was no significant difference in the incidence of CFH Y402H (P = 0.598) and HTRA1 rs11200638 (P = 0.290) between eyes with typical exudative AMD and with PCV.
|
18939352 |
2008 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
There was also no significant association between Chlamydia species IgG seropositivity and AMD status or severity, in patients carrying at least one CFH Y402H risk allele (C) or HTRA1 rs11200638 risk allele (A), with univariate or logistic regression analysis.
|
22259222 |
2012 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study shows that there was no association between the polymorphism rs11200638 in HTRA1 gene and response to anti-VEGF treatment of exudative AMD.
|
28637435 |
2017 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study strengthens the hypothesis of association between rs11200638</span> in the promoter of HTRA1 polymorphism and AMD.
|
19026638 |
2009 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
To determine age-related macular degeneration (AMD) phenotypes associated with mutually exclusive homozygotic risk variants in rs1061170 (CFH) and rs11200638 (HTRA1).
|
25627090 |
2015 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
To our knowledge, this is the first time the association between rs11200638 and overall age-related macular degeneration has been reported in South America.
|
28846052 |
2018 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Two hundred patients affected with exudative AMD were genotyped for the polymorphisms rs11200638 of the HTRA1 gene and rs10611710 of the CFH gene.
|
18362109 |
2008 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We and others have previously identified several polymorphisms on chromosome 10q26 (HTRA1 rs11200638 as well as LOC387715 rs10490924 and c.372_815del443ins54) associated with AMD.
|
27841854 |
2017 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We conclude that the rs11200638 variant in the HTRA1 gene is strongly associated with AMD in the Japanese population.
|
17568988 |
2007 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We confirmed the association of age-related maculopathy susceptibility 2 (ARMS2) rs10490924 (P=7.38 × 10<sup>-17</sup>), HTRA1 rs11200638 (P=5.47 × 10<sup>-17</sup>) and complement factor H gene (CFH) rs800292 (P=2.53 × 10<sup>-8</sup>) with neovascular AMD, all loci passing the genome-wide significance level (P<5.22 × 10<sup>-8</sup>).
|
28703135 |
2017 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We demonstrate that rs1120</span>0638 in the promoter region and rs2293870 in exon 1 of HTRA1, are among the most significantly associated variants for advanced forms of AMD.
|
18207215 |
2008 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We demonstrate that a single-nucleotide polymorphism, rs11200638, in the promoter region of HTRA1 is the most likely causal variant for AMD at 10q26 and is estimated to confer a population attributable risk of 49.3%.
|
17053109 |
2006 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped three SNPs, rs1061170 (exon 9, CFH), rs11200638 (HTRA1 promoter, -512 bp), and rs10490924 (6.6 kb upstream of HTRA1 in LOC387715/ARMS2) in 333 cases with advanced AMD (choroidal neovascularization [CNV] and geographic atrophy) and 171 age-matched examined controls.
|
18682806 |
2008 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped two SNPs that are located in the LOC387715 locus (rs10490924) and HTRA1 (rs11200638) in 137 cases of exudative AMD and 187 controls.
|
20456446 |
2010 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We investigated the frequency of Tyr402His polymorphism of the complement factor H (CFH) gene, Ser69Ala polymorphism at LOC387715, rs11200638 polymorphism of the HTRA1 gene and different apolipoprotein E (ApoE) alleles in Hungarian patients with AMD in order to determine the disease risk conferred by these factors.
|
19845562 |
2011 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We observed that homozygous risk genotypes (TT in rs10490924 and AA in rs11200638) were more strongly associated with AMD than the heterozygous genotypes (GT in rs10490924 and geographic atrophy in rs11200638) for both SNPs.
|
19491722 |
2009 |