|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Serum BDNF levels, but not plasma levels of HVA or MHPG, and BDNF Val66Met polymorphism are related to the mirtazapine response in MDD.
|
22883353 |
2012 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants.
|
17401528 |
2007 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant associations between AD and MDD have been found for three polymorphisms mainly in females (TPH1 A218C, MAOA VNTR and BDNF Val66Met) and one polymorphism in the total population only (FKBP5 rs1360780).
|
23157339 |
2013 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant interactions between the Val66Met polymorphism and 3 clinical characteristics - age at onset (p = 0.03), MDD duration (p = 0.04), and number of previous MDE (p = 0.04) - were evidenced for plasma BDNF levels.
|
28848102 |
2017 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Taken together, we did not detect any plausible evidence regarding Val66Met polymorphism in the BDNF gene contributing to a risk of MDD.
|
29387021 |
2017 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our study was to evaluate the association of regional gray matter (GM) volume within the hippocampus and other unpredicted regions at the whole-brain level with the BDNF Val66Met polymorphism in MDD patients with melancholic features and their impact on treatment outcome.
|
23165919 |
2013 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our two-center study was to determine how the BDNF Val66Met</span> polymorphism and childhood adversity affect the volumetric measures of the hippocampus in healthy individuals and people with MDD.
|
23341118 |
2013 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine which hippocampal dentate gyrus and cornu ammonis subfields are altered in MDD compared to healthy controls and which subfields are affected by the BDNF Val</span>66Met</span> polymorphism and child adversity.
|
25044977 |
2014 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of MDD with genetic polymorphisms, such as Val66Met (rs6265), in the brain derived neurotrophic factor (BDNF), have been reported in many studies and the results were conflicting.
|
23184535 |
2013 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF val66met polymorphism may play a salient role in structural alterations of the hippocampus in older adults with MDD.
|
21218562 |
2011 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF polymorphism was associated with atrophy of the PFC in MDD patients, which suggests that the BDNF Val66Met polymorphism may play an important role in the pathogenesis of early stages of MDD.
|
26078197 |
2015 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study looked at a population of patients with major depressive disorder (N = 107) to examine the association between the BDNF Val66Met polymorphism, resting state EEG alpha power, and depression severity.
|
23733090 |
2013 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The gene-environment combination of PRKCG rs3745406 C allele, BDNF rs6265 G allele and high level of negative life events (C-G-HN) was significantly associated with MDD (OR, 5.97; 95% CI, 2.71-13.15).
|
26921055 |
2016 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The pattern of low BDNF and high inflammation in MDD may be influenced by the Val66Met polymorphism.
|
28656803 |
2018 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study tested the hypothesis that the BDNF-gene Val66Met polymorphism is associated with MDD, its clinical manifestations, and antidepressant response.
|
14582140 |
2003 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The relationship was investigated between brain-derived neurotrophic factor (BDNF) concentrations, a <i>BDNF</i> polymorphism (196G>A), and the response to selective serotonin reuptake inhibitors (SSRIs) among Chinese patients with major depressive disorder (MDD).
|
31308724 |
2019 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The study indicated that having the BDNF rs6265 allele (A) increase the risk of developing MDD in the Malaysian population suggesting a possible role of BDNF in the etiology of the disorder.
|
30677092 |
2019 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results indicate that there was a lack of association between severity of depression and BDNF Val66Met polymorphism in Chinese patients with MDD.
|
20016225 |
2010 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the BDNF Val66Met polymorphism is not related to the development of MDD but related to clinical features of MDD in a Japanese population.
|
17510948 |
2007 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
This is a systematic meta-analytical review of findings from imaging genetic studies on the impact of the rs6265 SNP on hippocampal volumes in neuropsychiatric patients with major depressive disorder, anxiety, bipolar disorder or schizophrenia.
|
25956254 |
2015 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Three polymorphisms in the BDNF gene (rs7103411, rs6265 (Val66Met) and rs7124442) were genotyped in 324 patients with MDD and 470 healthy controls.
|
22965830 |
2013 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
To conclude, we did not replicate the Val66Met effect on hippocampal volume in neither patients with major depression nor in healthy participants.
|
19668114 |
2009 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine the effect of BDNF gene val66met polymorphism on serum BDNF levels in drug-free patients with major depressive disorder (MDD) and healthy subjects, that differ by gender.
|
19589373 |
2010 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine the effect of the BDNF Val66Met polymorphism on hippocampal and amygdala volumes in patients with major depression and in healthy control subjects.
|
17404118 |
2007 |
|
rs6265
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine whether the polymorphisms of BDNF (rs6265) and NTRK2 (rs1387923, rs2769605 and rs1565445) genes confer risk for TRD in major depressive disorder (MDD), a total of 948 MDD patients were recruited in a 12-week, multicenter, prospective longitudinal study.
|
23137999 |
2013 |