|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
102 patients with two or more consecutive abortions and 128 women without miscarriage were analyzed for factor V Leiden mutation (FVL), prothrombin G20210A mutation (PTM), C677T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, glycoprotein IIIa (GPIIIa) C1565T polymorphism, and beta-fibrinogen G-455A polymorphism by polymerase chain reaction (PCR) techniques.
|
11506076 |
2001 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further, in contrast to reports from other investigators, we found little evidence for association of a C677T polymorphism in the 5,10-methylenetetrahydrofolate reductase gene, the angiotensin-I-converting enzyme 1 insertion/deletion polymorphism, a 4G/5G polymorphism in the serine/cysteine proteinase inhibitor-clade E-member 1 gene, the factor V Leiden mutation, the G20210A factor II mutation, a -455G>A polymorphism in the beta-fibrinogen gene, the cys112arg/arg158cys apolipoprotein E gene polymorphism, a gly460trp polymorphism in the alpha-adducin gene, and a -629C>A polymorphism in the cholesteryl ester transfer protein gene with risk of MI.
|
16420563 |
2006 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
Plasma homocysteine, vitamin B12, folate, creatinine, and protein C levels were measured in all study subjects upon enrollment, and genotyping for the C677T and A1298C polymorphisisms of the methylenetetrahydrofolate reductase (MTHFR) gene and for factor V Leiden (FVL) mutations was performed as well.
|
20935614 |
2010 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
The -675 4G/5G PAI-1 allele distribution differed significantly between patients and controls (P = 0.020), but no difference was found regarding the distribution of -844 G/A PAI-1 (P = 0.493), FVL (P = 0.199), FIIG20210A (P = 0.410), FXIII-AVal34leu (P = 0.160) and C677T MTHFR (P = 0.788).
|
25699610 |
2015 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T Polymorphism and factor V Leiden mutation are not associated with recurrent spontaneous abortion of unexplained etiology in Japanese women.
|
16052395 |
2005 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study revealed mutations in hemophilia patients as follows: prothrombin G20210A (3 %), FVL (14 %), MTHFR C677T (42 %), and A1298C (59 %).
|
26891731 |
2016 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
The adjusted OR for VTE was 7.10 (95% CI: 2.33-21.61) in women with factor V Leiden (G1691A) mutation, 2.83 (95% CI: 0.70-11.63) in women with prothrombin G20210A mutation and 0.26 (95% CI: 0.10-0.65) in women with the MTHFR C677T mutation.
|
15208046 |
2004 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
To analyze the prevalence of factor V Leiden (G1691A), prothrombin (G20210A), and methylenetetrahydrofolate reductase (C677T) mutations in children with CP.
|
16382706 |
2005 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genetic predispositions to venous thrombosis such as factor V Leiden (FVL) mutation (Arg 506 Gln), prothrombin (FII) gene mutation (G20210A), and mutation of the methylenetetrahydrofolate reductase (MTHFR) gene (C677T) have been reported to be associated with recurrent pregnancy loss.
|
12042290 |
2002 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
Patients with beta-TM have insignificantly higher frequencies of mutant A allele in factor V Leiden G1691A (11.5 vs. 10.5%), mutant T allele in MTHFR C677T (21.5 vs. 21%) and mutant A allele in prothrombin G20210A (3 vs. 2.5%) than controls.
|
19710606 |
2009 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
The major genetic risk factor in our series of patients was homozygosity for the MTHFR C677T mutation (7 out of 48 patients); three more patients were found to be heterozygous for the Factor V Leiden mutation.
|
19432826 |
2009 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T polymorphism has a very high prevalence compared with the low prevalence of anticoagulant protein deficiency and factor V Leiden mutation in Mexicans.
|
26825628 |
2016 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nine hundred and two DNA samples of consenting healthy Saudi individuals were tested for factor V Leiden (FVL), prothrombin (PT) 20210 G>A, 5-10 methylenetetrahydrofolate reductase (MTHFR) 677 C>T, the 4G/5G polymorphism of Plasminogen activator inhibitor type 1 (PAI-1 4G/5G), and factor V HR2 (FVHR2) haplotype.
|
19838435 |
2009 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the prevalence of both the C677T MTHFR mutation and the factor V Leiden mutation in 81 patients with transient ischemic attack (TIA) or minor stroke (MS) and in 81 age- and sex-matched control subjects free from clinically manifest vascular disease.
|
9950259 |
1999 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
Patients and control subjects were tested for antithrombin protein C and protein S deficiencies, the presence of antiphospholipid antibodies (APLA), factor V Leiden (FVL), G20210A polymorphism of factor II gene (FII G20210A), and C677T polymorphism of 5,10-methylenetetrahydrofolate reductase gene (C677T MTHFR).
|
10835445 |
2000 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
Ethnic differences in the association of factor V Leiden mutation and the C677T methylenetetrahydrofolate reductase gene polymorphism with preeclampsia.
|
14746952 |
2004 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
This is a first report of the concordance of homozygous MTHFR C677T mutation in an individual with factor V Leiden mutation.
|
8840466 |
1996 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Factor V Leiden mutation (G1691A), and mutations in the prothrombin (G20210A) and 5,10-methylenetetrahydrofolate reductase (C677T) genes are common hereditary risk factors associated with venous thrombosis.
|
12490067 |
2002 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate whether the factor V Leiden mutation (FVL), the prothrombin gene G20210A variant or the methylenetetrahydrofolate reductase (MTHFR) C677T genotype are risk factors for central nervous system (CNS) thrombosis or intraventricular hemorrhage (IVH) in neonates.
|
12477269 |
2002 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
Factor V Leiden (FVL) G1691A, Prothrombin (PT) G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T and A128C mutations were evaluated in children with moderate-severe hemophilia A (n = 51) and controls (n = 25).
|
22411997 |
2014 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here we carried out an investigation of the most common inherited risk factors for hypercoagulability including the mutation in the factor V gene (factor V Leiden), the transition 20.210G-->A in the prothrombin gene, and also the homozygosity for the 677C-->T transition in the methylenetetrahydrofolate reductase gene (MTHFR).
|
9890294 |
1999 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
The presence of a variant allele for the 677C --> T MTHFR polymorphism strengthened the association between FVL and stillbirth (OR 3.34, 95%CI 1.95-5.73) (p(interaction) = 0.034).
|
16613994 |
2006 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
From 2008 to 2017, all 26 consecutive newborn infants ≥35 weeks of gestation diagnosed with neonatal CSVT, and their mothers, were tested for factor V Leiden (FV) G1691A, FII G20210A, and methylenetetrahydrofolate reductase C677T (MTHFR C677T) mutations.
|
31025572 |
2019 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although a clear association has been established between fetal loss and certain thrombophilic states, such as antiphospholipid antibody syndromes, antithrombin deficiency, and combined defects, reports on the prevalence of inherited prothrombotic defects such as factor V Leiden mutation and methylene tetrahydrofolate reductase C677T polymorphism in fetal loss are contradictory.
|
18160599 |
2008 |
|
rs1217691063
|
|
Factor V Leiden mutation
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, we have focused on the prevalence of methylenetetrahydrofolate reductase (MTHFR) C677T, dihydrofolate reductase (DHFR) 19-bp deletion within intron 1, factor V Leiden (FVL), and prothrombin (PT) G20210A polymorphisms in cancer patients with and without VTE.
|
18682947 |
2009 |