|
rs73132848
|
|
Hepatitis C
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A new 3p25 locus is associated with liver fibrosis progression in human immunodeficiency virus/hepatitis C virus-coinfected patients.
|
27339598 |
2016 |
|
rs7332270
|
|
Hepatitis C
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Impact of IFNL4 Genetic Variants on Sustained Virologic Response and Viremia in Hepatitis C Virus Genotype 3 Patients.
|
31260374 |
2019 |
|
rs74597329
|
|
Hepatitis C
|
T |
0.700 |
GeneticVariation
|
GWASCAT |
Multi-Ancestry Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus.
|
30593799 |
2019 |
|
rs74597329
|
|
Hepatitis C
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Impact of IFNL4 Genetic Variants on Sustained Virologic Response and Viremia in Hepatitis C Virus Genotype 3 Patients.
|
31260374 |
2019 |
|
rs75707332
|
|
Hepatitis C
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Impact of IFNL4 Genetic Variants on Sustained Virologic Response and Viremia in Hepatitis C Virus Genotype 3 Patients.
|
31260374 |
2019 |
|
rs76755915
|
|
Hepatitis C
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Impact of IFNL4 Genetic Variants on Sustained Virologic Response and Viremia in Hepatitis C Virus Genotype 3 Patients.
|
31260374 |
2019 |
|
rs76810409
|
|
Hepatitis C
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Impact of IFNL4 Genetic Variants on Sustained Virologic Response and Viremia in Hepatitis C Virus Genotype 3 Patients.
|
31260374 |
2019 |
|
rs79709413
|
|
Hepatitis C
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A new 3p25 locus is associated with liver fibrosis progression in human immunodeficiency virus/hepatitis C virus-coinfected patients.
|
27339598 |
2016 |
|
rs9380516
|
|
Hepatitis C
|
T |
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection.
|
22841784 |
2012 |
|
rs1127354
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Inosine triphosphate pyrophosphatase (ITPA) gene single nucleotide polymorphisms (SNPs), rs1127354 and rs7270101, may cause a functional impairment in ITPase enzyme, resulting anemia protection in patients with chronic hepatitis C virus (HCV) infection undergoing ribavirin (RBV)-dependent regimens.
|
29660762 |
2018 |
|
rs1127354
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ITPA gene polymorphism rs1127354 heterozygous genotype (CA) may influence Hb levels and protect against hemolytic anemia during RBV-containing regimens for HCV.
|
28480960 |
2017 |
|
rs1127354
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Multivariate analysis showed that IPTA rs1127354 non-genotype CC, HCV genotype, a baseline HCV RNA level <4 × 10 IU/mL, IL-28B rs12979860 genotype CC, and low liver fibrosis were independent predictors for SVR during the combination therapy.IPTA rs1127354 variants and related ITPase were not only related with ribavirin-induced hemolytic anemia but also directly affected the SVR to PEG-IFN plus ribavirin combination therapy in Chinese HCV-infected patients.
|
28723780 |
2017 |
|
rs1127354
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The prevalence of two functional polymorphisms (rs1127354 and rs7270101) of the inosine triphosphatase (ITPA) gene associated with ribavirin-induced hemolytic anemia (RIHA) during antiviral therapy for hepatitis C virus (HCV) infection varies by ethnicity.
|
28233743 |
2017 |
|
rs1127354
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ITPA SNP rs1127354 is a useful predictor of ribavirin-induced anemia in Taiwanese patients and may be related to more severe decreases in platelet counts during the early stage of HCV combination therapy.(Gut Liver, 2015;9214-223).
|
25287171 |
2015 |
|
rs1127354
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the ITPA SNP (rs7270101/rs1127354) frequency in healthy and hepatitis C virus (HCV)-infected patients from Brazil and the association with the development of severe anaemia during antiviral therapy.
|
26154744 |
2015 |
|
rs1127354
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
69 consecutive HCV-1 patients (mean age 57 years) with F3-F4 who received PR and TVR were genotyped for ITPA polymorphisms rs1127354 and rs7270101.
|
24760000 |
2014 |
|
rs1127354
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genotypes of the ITPA rs1127354 single nucleotide polymorphism were determined in 179 patients with HCV infection.
|
22052220 |
2012 |
|
rs1127354
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The role of rs1127354/rs7270101 alleles at the inosine triphosphatase (ITPA) gene on ribavirin-induced anemia was assessed in 74 patients with hepatitis C virus and human immunodeficiency virus coinfection.
|
22028438 |
2011 |
|
rs1127354
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Triple therapy for 12 weeks, followed by PEG-IFN and RBV for 12 weeks, was given to 49 patients with RBV-sensitive (CC at rs1127354) and 12 with RBV-resistant (CA/AA) ITPA genotypes who had been infected with hepatitis C virus (HCV) of genotype 1.
|
21246582 |
2011 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Host DNA from all HCV positive patients and age- and sex-matched non-HCV-infected control individuals were analysed for IL28B single nucleotide polymorphism (SNP) (rs12979860 and rs8099917).
|
30865664 |
2019 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms within the interferon λ (IFN-λ) chromosomal region, mainly rs12979860 of IFN-λ4 gene (IFNL4), are known as associated with spontaneous hepatitis C virus (HCV) resolution and sustained viral response to therapy with pegylated interferon- α and ribavirin.
|
30027841 |
2019 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The <i>IL28B</i> rs12979860 CT/TT genotypes (OR = 3.44, 95% CI [2.12-5.58], <i>p</i> < 0.001), bAt haplotype (OR = 2.02, 95% CI [1.04-3.91], <i>p</i> = 0.03), pre-treatment serum HCV RNA (logIU/mL; OR = 1.73, 95% CI [1.31-2.28], <i>p</i> < 0.001), advanced liver fibrosis (OR = 1.68, 95% CI [1.10-2.58], <i>p</i> = 0.02), and HCV genotype 1 (OR = 1.59, 95% CI [1.07-2.37], <i>p</i> = 0.02) independently predicted poor response.
|
31565578 |
2019 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The most significant positive factors affecting the SC HCV included IL-28B single nucleotide polymorphism (SNP) rs12979860 (CC) and SNP rs8099917 (TT) (OR 4.03, p<0.001) and (OR 3.14, p<0.002), female gender (OR 2.72, p<0.001), young age (OR 2.30, p<0.008), and past history of jaundice (OR 5.12, p<0.001).
|
31060998 |
2019 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Besides normal routine laboratory testing for HCV, patients' sera were evaluated also for retinol, retinol-binding protein 4 and the following SNPs: PNPLA3 (rs738409), TM6SF2 (rs58542926), MBOAT7 (rs641738), IL28B (rs12979860), TIMP-1 (rs4898), TIMP-2 (rs8179090), NF-kB promoter (rs28362491).
|
31826071 |
2019 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
<b>Results:</b> While the rs12979860 IFNL3 T allele was found a good marker associated with HCV-outcome together with the rs111200466 TLR2 del variant, the rs10204525 PD-1.6 A allele was found to have an insignificant role in patients with HCV-related hepatic disorders.
|
30930876 |
2019 |