|
rs1181860747
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Gly1057Asp polymorphism was not associated with insulin resistance or impaired insulin secretion in Finnish subjects with normal glucose tolerance (n = 295) or impaired glucose tolerance (n = 38).
|
11473060 |
2001 |
|
rs1217691063
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
Individuals with a family history of diabetes or with risk factors such as obesity, hypertension, and impaired glucose tolerance should be screened for MTHFR C677T mutation and may be prescribed folic acid, vitamin B6, and vitamin B12 to assess if this helps in delaying the onset of diabetes.
|
21186995 |
2011 |
|
rs121909244
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
Nes<sup>Cre</sup>/PPARγ-P467L mice fed either control diet or high-fat diet displayed impaired glucose tolerance yet exhibited increased sensitivity to exogenous insulin and increased insulin receptor signaling in white adipose tissue, liver, and skeletal muscle.
|
27575030 |
2016 |
|
rs121912438
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using physiological tests and a biophysics approach based on nuclear magnetic resonance (NMR), we unexpectedly found that SOD1(G93A) ALS mice suffered from severe glucose intolerance, which was counteracted by high intensity swimming but not moderate intensity running exercise.
|
29104532 |
2017 |
|
rs1229984
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant interactions were observed between alcohol and ADH1b (rs1229984) with respect to LDL and between alcohol and ALDH2 (rs886205) with respect to IGT/diabetes.
|
20700531 |
2010 |
|
rs13266634
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
And the pooled odds ratio (OR) for allelic frequency comparison showed that rs13266634 C/T polymorphism was also significantly associated with IGT: OR=1.15, 95% CI=1.06-1.26, P<0.001, P(heterogeneity)=0.364.
|
21131091 |
2011 |
|
rs13283456
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
The PTGES2 Arg298His polymorphism was reinvestigated in a population-based cross-sectional study (Cooperative Health Research in the Augsburg Region) consisting of 239 individuals with impaired glucose tolerance, 226 with type 2 diabetes, and 863 normoglycemic controls.
|
17566096 |
2007 |
|
rs137852787
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
The E224K mutation cosegregated with early-onset diabetes or impaired glucose tolerance in a large family, suggestive of the type 4 form of maturity-onset diabetes of the young rather than type 2 diabetes.
|
14764823 |
2004 |
|
rs1486559930
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
Examination of the P322S/+ metabolic phenotype revealed late-onset glucose intolerance.
|
31439647 |
2019 |
|
rs1527483
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
To identify rs1049673 and rs1527483 in the CD36 gene conferring susceptibility to IFG/IGT and T2D, we conducted a case-control study in 1257 essential hypertension patients among the Han Chinese population (control: 676; IGT/IFG: 468; T2D: 113).
|
22869067 |
2012 |
|
rs16139
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study thus provides the evidence that Leu7Pro polymorphism in the NPY gene is associated with IGT and T2DM in Swedish men, and indicates that the NPY gene variations contribute to development of T2DM.
|
15926114 |
2005 |
|
rs1693482
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
The ADH1c (rs1693482) fast metabolizing CC genotype was associated with an increased risk of impaired glucose tolerance (IGT)/diabetes compared to the CT and TT genotypes.
|
20700531 |
2010 |
|
rs17446593
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the German subjects at increased risk for type 2 diabetes, SNPs rs2721068 and rs17446614 were significantly (P = 0.0045 and P = 0.0018, respectively) and SNPs rs17446593 and rs2297627 were nominally (P = 0.0091 and P = 0.0387, respectively) associated with beta-cell dysfunction. rs2721068, rs17446614, and rs2297627 were also nominally associated with impaired glucose tolerance (P = 0.0264, P = 0.0162, and P = 0.0221, respectively).
|
19141580 |
2009 |
|
rs17446614
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the German subjects at increased risk for type 2 diabetes, SNPs rs2721068 and rs17446614 were significantly (P = 0.0045 and P = 0.0018, respectively) and SNPs rs17446593 and rs2297627 were nominally (P = 0.0091 and P = 0.0387, respectively) associated with beta-cell dysfunction. rs2721068, rs17446614, and rs2297627 were also nominally associated with impaired glucose tolerance (P = 0.0264, P = 0.0162, and P = 0.0221, respectively).
|
19141580 |
2009 |
|
rs1799883
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
(1) The Ala54 and Thr54 allele frequencies in Chinese were 0.71 and 0.29 respectively; (2) The FABP2-Ala54Thr variation was neither associated with fasting and post-challenged plasma glucose levels nor with NIDDM; (3) This variation was neither associated with fasting lipid profile nor with obesity; (4) The IGT subjects with genotype Thr54(+) (Thr54 homozygotes and heterozygotes) had lower fasting, 2-hour and total C-peptide levels and smaller AUC representing lesser C-peptide secretion after glucose challenge than those with genotype Thr54(-) (Ala54 homozygotes) (P = 0.04, 0.03, 0.01 and 0.01 respectively).
|
11593593 |
1999 |
|
rs1799983
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
The eNOS G894T polymorphism appears to be predictive of persistent hyperglycemia in Chinese subjects with IGT.
|
16919532 |
2006 |
|
rs1799999
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, we found no evidence in Swedish men that the PP1ARE or the Asp905Tyr variants over a 20-year period predict the development of IGT or type 2 diabetes, but the PP1ARE polymorphism could have a higher penetrance in other populations.
|
10868947 |
2000 |
|
rs1800562
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
Allele frequencies of C282Y and H63D did not differ between diabetic and control groups nor among subjects with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and diabetes.
|
12148086 |
2002 |
|
rs1801278
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
To assess the relevance of a Gly-->Arg substitution in codon 972 of the insulin receptor substrate-1 gene in impaired glucose tolerance (IGT) and NIDDM.
|
9589236 |
1998 |
|
rs1805094
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
In premenopausal women with IGT</span> (n = 65), associations were found with Lys(109)Arg and Lys(656)Asn for overall glucose response to the glucose load.
|
11443193 |
2001 |
|
rs1884614
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the P2 promoter, the htSNP rs1884614 showed borderline association with both type 2 diabetes (OR 1.40, P = 0.09) and the combined type 2 diabetes/IGT trait (1.35, P = 0.07).
|
15561969 |
2004 |
|
rs2073162
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
The same two markers together with rs2073162 associated with the conversion of IGT to T2D in men.
|
17495183 |
2007 |
|
rs2233580
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the logistic regression analysis, the most important factor predicting IGT and IR was older age of survivors (P=0.014 and P<0.001, respectively) whereas the PAX4 R192H mutation (rs2233580) was significantly associated with IGT after adjustment for age (P=0.043) (adjusted OR 5.28, 95% CI 1.06-26.40).
|
20485196 |
2010 |
|
rs2278426
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rates of T2D and IGT were greater in subjects with the R59W variant.
|
29397342 |
2019 |
|
rs2293855
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, the G allele of rs2293855 was associated with glucose intolerance (fasting glucose, P=0.012; glucose AUC, P=0.006; 2-h glucose, P=0.024); it is also associated with decreased indices of insulin sensitivity (fasting insulin, P=0.043; insulin sensitivity index composite, P=0.009; homeostasis model assessment of insulin resistance, HOMA-IR, P=0.008) and decreased indices of insulin secretion (HOMA of beta cell function, HOMA-B, P=0.028; insulinogenic index, P=0.003).
|
24937802 |
2014 |