Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.040 GeneticVariation BEFREE Association of <i>IL-6</i> -174G>C (rs1800795) polymorphism with cervical cancer susceptibility. 30135142

2018
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.040 GeneticVariation BEFREE Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC. 27722983

2017
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.040 GeneticVariation BEFREE Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC. 27722983

2017
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.040 GeneticVariation BEFREE Subgroup analysis indicated that rs1800795 was significantly associated with increased risk of cervical cancer, colorectal cancer, breast cancer, prostate cancer, lung cancer, glioma, non-Hodgkin's lymphoma and Hodgkin's lymphoma but not gastric cancer and multiple myeloma. 29552316

2018
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.040 GeneticVariation BEFREE The C allele of rs1800795 within IL-6 gene promoter, rs1800795-tobacco smoking and rs1800795-alcohol drinking interaction were all associated with increased CAD risk. 29889576

2018
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.040 GeneticVariation BEFREE Our results show that the C genotype of interleukin 6 rs1800795 is associated with higher cervical cancer risk. 27777338

2017
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.040 GeneticVariation BEFREE GG genotypes of rs1800795 in IL-6 was also associated with occurrence of tuberculosis in our patients with TA. 28438554

2018
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 GeneticVariation BEFREE Having a C allele of the rs1800796 IL6 polymorphisms and the GG genotype of the rs1800795 IL6 polymorphisms was associated with a statistically significantly reduced the risk of colon (OR 0.76 95% CI 0.57, 1.00), but not rectal (OR 1.49 95% CI 1.02,2.16) cancer. 17694420

2007
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.040 GeneticVariation BEFREE Association of <i>IL-6</i> -174G>C (rs1800795) polymorphism with cervical cancer susceptibility. 30135142

2018
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 GeneticVariation BEFREE Simultaneously, rs1800795 and rs1800796 were associated with a significantly higher risk of cancer in Asia and Caucasian, rs1800797 was associated with a significantly risk of cancer in Caucasian but not in Asia. 29552316

2018
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 GeneticVariation BEFREE To date, several association studies examining rs1800795 allele frequency and disease risk have reported seemingly conflicting results ranging from no association to association with either the major or minor allele across a spectrum of conditions, including cancer and autoimmune, cardiovascular, infectious, and metabolic diseases. 26578807

2015
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.040 GeneticVariation BEFREE IL-6 174 G>C rs1800795 was associated with CAD risk in a Chinese population. 25299085

2014
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.040 GeneticVariation BEFREE Collectively, this meta-analysis proved that IL-6 rs1800795, IL-18 rs1946518 and IL-18 rs187238 polymorphisms may confer susceptibility to TB, especially for Asians. 31676365

2020
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 GeneticVariation BEFREE To date, several association studies examining rs1800795 allele frequency and disease risk have reported seemingly conflicting results ranging from no association to association with either the major or minor allele across a spectrum of conditions, including cancer and autoimmune, cardiovascular, infectious, and metabolic diseases. 26578807

2015
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.040 GeneticVariation BEFREE Subgroup analysis indicated that rs1800795 was significantly associated with increased risk of cervical cancer, colorectal cancer, breast cancer, prostate cancer, lung cancer, glioma, non-Hodgkin's lymphoma and Hodgkin's lymphoma but not gastric cancer and multiple myeloma. 29552316

2018
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.040 GeneticVariation BEFREE Collectively, this meta-analysis proved that IL-2 rs2069762, IL-4 rs2243250, IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871 and IL-10 rs1800896 polymorphisms may confer susceptibility to TB, especially for Asians. 31669382

2020
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.040 GeneticVariation BEFREE Subgroup analysis indicated that rs1800795 was significantly associated with increased risk of cervical cancer, colorectal cancer, breast cancer, prostate cancer, lung cancer, glioma, non-Hodgkin's lymphoma and Hodgkin's lymphoma but not gastric cancer and multiple myeloma. 29552316

2018
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 GeneticVariation BEFREE Simultaneously, rs1800795 and rs1800796 were associated with a significantly higher risk of cancer in Asia and Caucasian, rs1800797 was associated with a significantly risk of cancer in Caucasian but not in Asia. 29552316

2018
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.040 GeneticVariation BEFREE Collectively, this meta-analysis proved that IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871, IL-10 rs1800872 and IL-10 rs1800896 may confer susceptibility to TB. 31560754

2019
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.040 GeneticVariation BEFREE Our results show that the C genotype of interleukin 6 rs1800795 is associated with higher cervical cancer risk. 27777338

2017
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 GeneticVariation BEFREE We observed a non-significant association between rs1800795 and overall cancer risk, while rs1800797 was found to have a false positive association with overall risk of cancer. 29842912

2018
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.040 GeneticVariation BEFREE Association of <i>IL-6</i> -174G>C (rs1800795) polymorphism with cervical cancer susceptibility. 30135142

2018
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.040 GeneticVariation BEFREE Our results show that the C genotype of interleukin 6 rs1800795 is associated with higher cervical cancer risk. 27777338

2017
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 GeneticVariation BEFREE Having a C allele of the rs1800796 IL6 polymorphisms and the GG genotype of the rs1800795 IL6 polymorphisms was associated with a statistically significantly reduced the risk of colon (OR 0.76 95% CI 0.57, 1.00), but not rectal (OR 1.49 95% CI 1.02,2.16) cancer. 17694420

2007
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.040 GeneticVariation BEFREE Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC. 27722983

2017