|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The AMD cases possessing the LOC387715 (rs10490924) variant may have a higher risk of neovascular AMD.
|
17210853 |
2007 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The CFB variant 32W was associated with protection against neovascular AMD, compared to the common 32R variant (odds ratio 0.64, p<0.05, in logistic regression with CFB variants; odds ratio 0.53, p<0.05, in logistic regression with CFB variants, CFH haplotypes, HTRA1 rs10490924 genotype, and smoking status).
|
21541267 |
2011 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found associations with nvAMD for <i>CFHY402H</i> variant (rs1061170) (OR=1.99, 95% CI 1.67 to 2.37, P=10<sup>-6</sup>), <i>ARMS2</i> (rs10490924) (OR=2.94, 95% CI 2.45 to 3.52, P=10<sup>-9</sup>), <i>C2</i> (rs547154) (OR=0.67, 95% CI 0.53 to 0.85, P=0.01), <i>ABCA1</i> (rs1883025) (OR=0.77, 95% CI 0.65 to 0.92, P=0.04) and an SNP near <i>VEGFA</i> (rs4711751) (OR=0.64, 95% CI 0.54 to 0.77, P=10<sup>-3</sup>).
|
29259020 |
2018 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
ARMS2 rs10490924 was also significantly associated with the risk allele T found at a frequency of 0.5 in AMD and 0.15 in controls (p < 0.017, χ(2) test).
|
23362846 |
2013 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
GWASDB |
Seven new loci associated with age-related macular degeneration.
|
23455636 |
2013 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The final model included the following independent variables: age, smoking history, family history of AMD (first-degree member), phenotype based on a modified Age-Related Eye Disease Study simple scale score, and genetic variants CFH Y402H and ARMS2 A69S.
|
21825180 |
2011 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
To determine the association of high-risk alleles in the complement factor H (CFH; Y402H, rs1061170) and age-related maculopathy susceptibility (ARMS2; A69S, rs10490924) genes with reticular macular disease (RMD), a major clinical subphenotype of age-related macular degeneration (AMD).
|
21825189 |
2011 |
|
rs10490924
|
|
Age related macular degeneration
|
T |
0.900 |
GeneticVariation
|
GWASDB |
Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.
|
22705344 |
2012 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Early identification of individuals with genetic risk variants CFH p.Y402H and ARMS2 p.A69S is clinically important for the definition of AMD status.
|
22706242 |
2012 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
After adjusting for rs11200638, ARMS2 rs10490924 remained significantly associated with exudative AMD (P = 0.011), but not with PCV (P = 0.077).
|
22491416 |
2012 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We and others have previously identified several polymorphisms on chromosome 10q26 (HTRA1 rs11200638 as well as LOC387715 rs10490924 and c.372_815del443ins54) associated with AMD.
|
27841854 |
2017 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The p.Ala69Ser polymorphism of the ARMS2 gene is strongly associated with exudative AMD and PCV and is associated marginally with dry AMD.
|
21236409 |
2011 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The risk alleles in C3 (rs1047286, odds ratio [OR]=2.48, 95% confidence interval [CI]=1.64-3.75, p=1.59E-05; rs2230199, OR=2.15, 95% CI=1.48-3.13, p=6.28E-05) and in ARMS2 (rs10490924, OR=3.09, 95% CI=2.48-3.86, p=5.42E-23) were strongly associated with risk of AMD.
|
24453474 |
2014 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped three SNPs, rs1061170 (exon 9, CFH), rs11200638 (HTRA1 promoter, -512 bp), and rs10490924 (6.6 kb upstream of HTRA1 in LOC387715/ARMS2) in 333 cases with advanced AMD (choroidal neovascularization [CNV] and geographic atrophy) and 171 age-matched examined controls.
|
18682806 |
2008 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
To examine phenotypes of age-related macular degeneration (AMD) patients with the LOC387715 variant (T allele at rs10490924, A69S).
|
18061132 |
2008 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genotype distributions of ARMS2 (A69S) and CFH (I62V) in patients with CVH and type 1 CNV significantly differed from those of AMD cases (P = 0.0014 and 0.0098, respectively), but not from general population controls (P = 0.33 and 0.82, statistical power of 88.5% and 72.9%, respectively).
|
24781946 |
2014 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Korean individuals with the LOC387715/ARMS2 rs10490924, and to a lesser extent, CFH rs800292 variants might be at a greater risk for the development of exudative AMD.
|
23289807 |
2013 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
HTRA1 rs11200638 G→A polymorphism and LOC387715/ARMS2 rs10490924 G→T polymorphism play important roles in AMD.
|
21031019 |
2010 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped two SNPs that are located in the LOC387715 locus (rs10490924) and HTRA1 (rs11200638) in 137 cases of exudative AMD and 187 controls.
|
20456446 |
2010 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
With regard to <i>ARMS2</i>, the variation is most pronounced in testes: homozygotes with the high-AMD-risk haplotype express <i>ARMS2</i> at lower levels than homozygotes with the low-AMD-risk haplotype; expression in heterozygotes falls in between (rs10490924 effect size -0.79, p = 7.5 x 10<sup>-24</sup>).
|
28659708 |
2017 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Association of combined cigarette smoking and ARMS2/LOC387715 A69S polymorphisms with age-related macular degeneration: A meta-analysis.
|
28095100 |
2017 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
To evaluate the association of extramacular drusen (EMD) with age-related macular degeneration (AMD) and with complement factor H (CFH rs1061170) and age-related maculopathy susceptibility 2 (ARMS2 rs10490924) polymorphisms in individuals with and without AMD.
|
26614632 |
2016 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
LOC387715 rs10490924 was associated with PCV and its clinical manifestations, and showed a discrepant distribution between PCV and AMD.
|
22509112 |
2012 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
One haplotype, which contained the T allele of the rs10490924 (A69S) and the variant of de1443ins54 polymorphism, had an odds ratio of 3.14 (P = 7.8 x 10(-6)) for AMD and 2.00 (P = .0058) for PCV.
|
19268887 |
2009 |
|
rs10490924
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
1093 patients with exudative AMD and 396 controls have been recruited and genotyped for the Y402H of CFH, rs10490924 of ARMS2 and T280M of the CX3CR1 gene.
|
21621535 |
2011 |