rs11931074
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
SNCA rs11931074 polymorphism is found to be associated with PD risk and this risk appears to be influenced by genetic status and ethnicity.
|
31758346 |
2020 |
rs11931074
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In an interaction analysis, SNP rs11931074-PD status interaction was significantly associated with positive α-Syn immunostaining in the ENS (OR = 7.33, 95% CI = 1.58-33.88, P = 0.01).
|
30424941 |
2019 |
rs11931074
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Also blood sample of each participant was genotyped for rs11931074 polymorphism (PD: TT = 19, GT = 32, GG = 11; HC: TT = 10, GT = 25, GG = 12) and then examined to ascertain the influence of different genotypes on regional brain activity with amplitude low-frequency fluctuation analysis (ALFF).
|
31243602 |
2019 |
rs11931074
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, our meta-analysis further indicates that the SNCA rs11931074 polymorphism contributes to PD susceptibility.
|
30120622 |
2018 |
rs11931074
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The association of rs11931074 with decreased risk of PD was also significant.
|
26732583 |
2016 |
rs11931074
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Subgroup analysis of patients with both clinical and genetic results demonstrated that after adjusting for age, sex, chronic constipation and cpRBD, rs11931074 TT genotype may increase the risk of hyposmia in PD (OR = 3.24 95% CI = 1.23-8.51, p = 0.017) compared to GG genotype via an additive model.
|
25921825 |
2015 |
rs11931074
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results suggest that the rs3822086 (C) allele and rs11931074 (G) allele in SNCA decrease the risk for PD, and SNCA rs11931074 may affect frontal lobe dysfunction of MSA in the Chinese population.
|
26208350 |
2015 |
rs11931074
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found that Rep1, rs356165, and rs11931074 in SNCA gene; G2385R in LRRK2 gene; rs4698412 in BST1 gene; rs1564282 in PARK17; and L444P in GBA gene were associated with PD with adjustment of sex and age (p < 0.05) in the analysis of 16 variants.
|
25623333 |
2015 |
rs11931074
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Alpha-synuclein transcript isoforms in three different brain regions from Parkinson's disease and healthy subjects in relation to the SNCA rs356165/rs11931074 polymorphisms.
|
24418406 |
2014 |
rs11931074
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The SNP rs894278 confers risk via a dominant model and an additive model, whereas the minor allele G of rs11931074 reduces the risk of PD progression.
|
23853107 |
2013 |
rs11931074
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study showed that two SNPs near the promoter region (rs2301134 and rs2301135) of SNCA gene gave the greatest evidence for an association with PD (p ≤ 0.01) and a haplotype block with two SNPs in the 3' UTR (rs356221 and rs11931074) revealed another evidence of association (p ≤ 0.02).
|
23182315 |
2013 |
rs11931074
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Of those, the SNCA SNP rs11931074 showed the most significant association with PD susceptibility (adjusted odds ratio = 1.48; 95% confidence interval = 1.31-1.67; p = 2.20E-10).
|
23820587 |
2013 |
rs11931074
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
|
22438815 |
2012 |
rs11931074
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
|
21738487 |
2011 |
rs11931074
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study reveals genetic risk underlying Parkinson's disease.
|
19915575 |
2009 |
rs11931074
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
|
19915576 |
2009 |
rs11931074
|
|
Parkinson Disease
|
G |
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
|
19915576 |
2009 |
rs3129882
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results of this meta-analysis suggest that HLA-DRA rs3129882 A/G polymorphism was not responsible for PD in Chinese-based populations.
|
24849299 |
2015 |
rs3129882
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In current meta-analysis, no significant association was found for rs3129882 and PD risk.
|
25720714 |
2015 |
rs3129882
|
|
Parkinson Disease
|
G |
0.900 |
GeneticVariation
|
GWASDB |
HLA_rs3129882 was more strongly associated with Sporadic-PD (OR = 1.38, P = 5 × 10(-10)) than Familial-PD (OR = 1.12, P = 0.15).
|
24511991 |
2014 |
rs3129882
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
HLA_rs3129882 was more strongly associated with Sporadic-PD (OR = 1.38, P = 5 × 10(-10)) than Familial-PD (OR = 1.12, P = 0.15).
|
24511991 |
2014 |
rs3129882
|
|
Parkinson Disease
|
G |
0.900 |
GeneticVariation
|
GWASCAT |
HLA_rs3129882 was more strongly associated with Sporadic-PD (OR = 1.38, P = 5 × 10(-10)) than Familial-PD (OR = 1.12, P = 0.15).
|
24511991 |
2014 |
rs3129882
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results suggest that rs3129882 polymorphism may be a risk factor for PD in Iranian.
|
25319953 |
2014 |
rs3129882
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genetic interaction analysis revealed that subjects simultaneously carrying the T allele (TC or TT) of rs11248051 and the A allele (AG or AA) of rs3129882 had an aggravated risk (OR 1.91; p=0.016) of PD.
|
24373818 |
2014 |
rs3129882
|
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Similarly, rs3129882 and the closely linked rs9268515 and rs2395163 remained significant irrespective of HLA alleles. rs3129882 and rs2395163 are expression quantitative trait loci (eQTLs) for HLA-DR and HLA-DQ (9 × 10(-5) ≥ PeQTL ≥ 2 × 10(-79)), suggesting that HLA gene expression might influence PD.
|
24183452 |
2013 |